PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAPPC1	0	TRAPPC4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
STIL	3	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC4	2	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
PDLIM7	0	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
TRAPPC1	0	TRAPPC10	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Scrivens PJ (2011), Huttlin EL (2017), Boldt K (2016)	3
TRAPPC9	6	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
CEP128	1	PDLIM7	0	bioid	Gupta GD (2015)	1
CDH1	4	PDLIM7	0	bioid	Guo Z (2014)	1
RAB3IL1	0	RAB3IP	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	6
CEP89	2	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC9	6	RAB3IP	0	affinity chromatography technology	Boldt K (2016)	1
RAB3IP	0	TMEM102	0	affinity chromatography technology	Boldt K (2016)	1
CEP128	1	CEP170	4	bioid	Gupta GD (2015)	1
CC2D2A	3	MB21D2	2	bioid	Gupta GD (2015)	1
CENPJ	6	STIL	3	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
MKS1	3	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC1	0	TMEM102	0	affinity chromatography technology	Boldt K (2016)	1
CENPJ	6	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC1	0	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
TMEM17	0	MKS1	3	bioid	Gupta GD (2015)	1
RAB3IP	0	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
AHI1	4	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC4	2	TRAPPC10	7	two hybrid, affinity chromatography technology	Scrivens PJ (2011), Boldt K (2016)	2
TMEM216	0	MB21D2	2	bioid	Gupta GD (2015)	1
RAB3IL1	0	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
RAB3IL1	0	TRAPPC2L	0	affinity chromatography technology	Boldt K (2016)	1
CC2D2A	3	AHI1	4	bioid	Gupta GD (2015)	1
CDH1	4	MB21D2	2	bioid	Guo Z (2014)	1
TRAPPC3	0	RAB3IP	0	affinity chromatography technology	Boldt K (2016)	1
CEP89	2	CEP170	4	bioid	Gupta GD (2015)	1
TMEM17	0	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC9	6	TRAPPC3	0	affinity chromatography technology	Boldt K (2016)	1
CENPJ	6	CEP170	4	bioid	Gupta GD (2015)	1
CEP128	1	CNTROB	6	bioid	Gupta GD (2015)	1
PDLIM7	0	TRAPPC10	7	affinity chromatography technology	Boldt K (2016)	1
RAB3IL1	0	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC1	0	RAB3IL1	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC2L	0	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
CNTROB	6	MB21D2	2	bioid	Gupta GD (2015)	1
TMEM102	0	TRAPPC10	7	affinity chromatography technology	Boldt K (2016)	1
TRAPPC4	2	TMEM102	0	affinity chromatography technology	Boldt K (2016)	1
RAB3IP	0	TRAPPC10	7	affinity chromatography technology	Boldt K (2016)	1
TRAPPC9	6	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
CC2D2A	3	MKS1	3	bioid	Gupta GD (2015)	1
RAB3IP	0	CEP170	4	affinity chromatography technology	Boldt K (2016)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
TRAPPC3	0	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
RAB3IP	0	TRAPPC2L	0	affinity chromatography technology	Boldt K (2016)	1
CEP128	1	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC1	0	TRAPPC3	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Scrivens PJ (2011), Scrivens PJ (2011), Huttlin EL (2017), Boldt K (2016)	4
TRAPPC4	2	TRAPPC2L	0	two hybrid, affinity chromatography technology	Scrivens PJ (2011), Boldt K (2016)	2
KCNJ6	6	MB21D2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRAPPC3	0	TRAPPC2L	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Choi C (2011), Scrivens PJ (2011), Scrivens PJ (2011), Rolland T (2014), Boldt K (2016)	6
TRAPPC4	2	TRAPPC9	6	two hybrid, affinity chromatography technology	Scrivens PJ (2011), Boldt K (2016)	2
CAVIN1	0	MB21D2	2	affinity chromatography technology	Huttlin EL (2017)	1
RAB3IL1	0	TMEM102	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
TRAPPC3	0	RAB3IL1	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC1	0	TRAPPC9	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
TRAPPC2L	0	TRAPPC9	6	affinity chromatography technology, affinity chromatography technology	Scrivens PJ (2011), Boldt K (2016)	2
TRAPPC3	0	TMEM102	0	affinity chromatography technology	Boldt K (2016)	1
CEP104	4	CEP170	4	bioid	Gupta GD (2015)	1
TRAPPC3	0	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC9	6	TRAPPC10	7	two hybrid, affinity chromatography technology	Scrivens PJ (2011), Boldt K (2016)	2
TRAPPC2L	0	TRAPPC10	7	affinity chromatography technology, two hybrid, affinity chromatography technology	Scrivens PJ (2011), Scrivens PJ (2011), Boldt K (2016)	3
TRAPPC4	2	TRAPPC3	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
TRAPPC1	0	TRAPPC2L	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
TMEM102	0	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
TMEM102	0	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
TMEM102	0	TRAPPC2L	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC9	6	RAB3IL1	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC4	2	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
TRAPPC9	6	TMEM102	0	affinity chromatography technology	Boldt K (2016)	1
RAB3IL1	0	TRAPPC10	7	affinity chromatography technology	Boldt K (2016)	1
TRAPPC10	7	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
RAB3IP	0	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
TRAPPC4	2	RAB3IL1	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC1	0	PDLIM7	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC1	0	RAB3IP	0	affinity chromatography technology	Boldt K (2016)	1
TRAPPC2L	0	MB21D2	2	affinity chromatography technology	Boldt K (2016)	1
CEP170	4	MB21D2	2	bioid	Gupta GD (2015)	1
CEP104	4	MB21D2	2	bioid	Gupta GD (2015)	1
TRAPPC3	0	TRAPPC10	7	affinity chromatography technology	Boldt K (2016)	1
TRAPPC4	2	RAB3IP	0	affinity chromatography technology	Boldt K (2016)	1