Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ADRA2B 151 ETOMIDATE CHEMBL681 agonist TdgClinicalTrial, TEND, DrugBank 14508322, 20496522
ADRA2B 151 GUANABENZ CHEMBL420 agonist, binder GuideToPharmacologyInteractions, DrugBank 1666366
ADRA2B 151 PALIPERIDONE CHEMBL1621 antagonist DrugBank 11132243
ADRA2B 151 LEVOMEPROMAZINE CHEMBL1764 antagonist DrugBank 2870716, 15701205, 6149771
ADRA2B 151 METHAMPHETAMINE CHEMBL1201201 agonist TdgClinicalTrial, DrugBank 15955613, 9551769
ADRA2B 151 DRONEDARONE CHEMBL184412 DrugBank 17389667
ADRA2B 151 MIANSERIN CHEMBL6437 antagonist DrugBank
ADRA2B 151 BETHANIDINE CHEMBL1201260 TdgClinicalTrial, TEND
ADRA2B 151 ASENAPINE (CHEMBL3187365) CHEMBL3187365 TdgClinicalTrial
ADRA2B 151 LOFEXIDINE CHEMBL17860 TdgClinicalTrial, TEND
ADRA2B 151 CHLORPROMAZINE CHEMBL71 antagonist GuideToPharmacologyInteractions
ADRA2B 151 ZOTEPINE CHEMBL285802 antagonist GuideToPharmacologyInteractions
ADRA2B 151 DIPIVEFRIN HYDROCHLORIDE CHEMBL1200833 agonist ChemblInteractions
ADRA2B 151 EPINEPHRINE BITARTRATE CHEMBL1256958 agonist ChemblInteractions
ADRA2B 151 FADOLMIDINE HYDROCHLORIDE CHEMBL2106710 agonist ChemblInteractions
ADRA2B 151 BRIMONIDINE TARTRATE CHEMBL2062257 agonist ChemblInteractions
ADRA2B 151 GUANFACINE HYDROCHLORIDE CHEMBL1200494 agonist ChemblInteractions
ADRA2B 151 TIZANIDINE HYDROCHLORIDE CHEMBL1200329 agonist ChemblInteractions
ADRA2B 151 HYDROXYAMPHETAMINE HYDROBROMIDE CHEMBL1200705 agonist ChemblInteractions
ADRA2B 151 ARIPIPRAZOLE CHEMBL1112 antagonist DrugBank 17848919
ADRA2B 151 ROPINIROLE CHEMBL589 agonist DrugBank 18691132
ADRA2B 151 CARVEDILOL CHEMBL723 antagonist DrugBank 15306222
ADRA2B 151 DEBRISOQUIN CHEMBL169901 TdgClinicalTrial, TEND
ADRA2B 151 TIZANIDINE CHEMBL1079 TdgClinicalTrial
ADRA2B 151 BROMOCRIPTINE CHEMBL493 antagonist GuideToPharmacologyInteractions
ADRA2B 151 MIRTAZAPINE CHEMBL654 antagonist GuideToPharmacologyInteractions, ChemblInteractions
ADRA2B 151 PHENTOLAMINE CHEMBL597 antagonist GuideToPharmacologyInteractions
ADRA2B 151 ROXINDOLE CHEMBL431367 antagonist GuideToPharmacologyInteractions
ADRA2B 151 CHEMBL10332 CHEMBL10332 antagonist GuideToPharmacologyInteractions
ADRA2B 151 SPIROXATRINE CHEMBL300555 antagonist GuideToPharmacologyInteractions
ADRA2B 151 CHEMBL25554 CHEMBL25554 antagonist GuideToPharmacologyInteractions
ADRA2B 151 LABETALOL HYDROCHLORIDE CHEMBL1200323 antagonist ChemblInteractions
ADRA2B 151 NORADRENALINE CHEMBL1356607 agonist ChemblInteractions
ADRA2B 151 METHYLDOPA CHEMBL459 agonist ChemblInteractions
ADRA2B 151 ERGOTAMINE TARTRATE CHEMBL2062265 agonist ChemblInteractions
ADRA2B 151 NAPHAZOLINE HYDROCHLORIDE CHEMBL1706 agonist ChemblInteractions
ADRA2B 151 TETRAHYDROZOLINE HYDROCHLORIDE CHEMBL1200413 agonist ChemblInteractions
ADRA2B 151 CLONIDINE HYDROCHLORIDE CHEMBL1705 agonist ChemblInteractions
ADRA2B 151 METHYLDOPATE HYDROCHLORIDE CHEMBL1200432 agonist ChemblInteractions
ADRA2B 151 GUANABENZ ACETATE CHEMBL1200560 agonist ChemblInteractions
ADRA2B 151 ALSEROXYLON CHEMBL1201454 antagonist ChemblInteractions
ADRA2B 151 ESMIRTAZAPINE MALEATE CHEMBL2107339 antagonist ChemblInteractions
ADRA2B 151 LEVONORDEFRIN CHEMBL677 agonist ChemblInteractions
ADRA2B 151 NOREPINEPHRINE CHEMBL1437 agonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423, 18064417, 11053214, 1979424, 11728431, 1980236
ADRA2B 151 CABERGOLINE CHEMBL1201087 antagonist GuideToPharmacologyInteractions, DrugBank 10641988, 18691132, 18992242, 12388667
ADRA2B 151 CLOZAPINE CHEMBL42 antagonist DrugBank 17848919
ADRA2B 151 LOXAPINE CHEMBL831 binder DrugBank
ADRA2B 151 LISURIDE CHEMBL157138 antagonist GuideToPharmacologyInteractions, DrugBank 18691132
ADRA2B 151 ERGOTAMINE CHEMBL442 partial agonist, agonist DrugBank 17139284, 17016423
ADRA2B 151 APOMORPHINE CHEMBL53 agonist, antagonist GuideToPharmacologyInteractions, DrugBank 18691132
ADRA2B 151 RISPERIDONE CHEMBL85 agonist, antagonist DrugBank 15907153, 11132243
ADRA2B 151 CHEMBL609728 CHEMBL609728 DrugBank
ADRA2B 151 DROXIDOPA CHEMBL2103827 agonist ChemblInteractions, DrugBank 21173850, 18064417, 18680204
ADRA2B 151 XYLOMETAZOLINE CHEMBL312448 agonist DrugBank 20030735
ADRA2B 151 EPINEPHRINE CHEMBL679 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions
ADRA2B 151 CLONIDINE CHEMBL134 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions
ADRA2B 151 BRIMONIDINE CHEMBL844 agonist GuideToPharmacologyInteractions, TEND
ADRA2B 151 SENREBOTASE CHEMBL3137348 TdgClinicalTrial
ADRA2B 151 DEXMEDETOMIDINE CHEMBL778 agonist GuideToPharmacologyInteractions
ADRA2B 151 OXYMETAZOLINE CHEMBL762 agonist GuideToPharmacologyInteractions
ADRA2B 151 PERGOLIDE CHEMBL531 agonist GuideToPharmacologyInteractions
ADRA2B 151 PHENOXYBENZAMINE CHEMBL753 antagonist GuideToPharmacologyInteractions
ADRA2B 151 RAUWOLFIA SERPENTINA (CHEMBL3559672) CHEMBL3559672 antagonist ChemblInteractions
ADRA2B 151 PHENTOLAMINE MESYLATE CHEMBL1200873 antagonist ChemblInteractions
ADRA2B 151 OXYMETAZOLINE HYDROCHLORIDE CHEMBL1200791 agonist ChemblInteractions
ADRA2B 151 OLANZAPINE CHEMBL715 antagonist TdgClinicalTrial, DrugBank 17848919
ADRA2B 151 FENOLDOPAM CHEMBL588 antagonist TEND, DrugBank 7670737, 17139284, 17016423
ADRA2B 151 YOHIMBINE CHEMBL15245 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 17123717, 10611634, 8872361, 12170055, 10822066, 12110610
ADRA2B 151 FIPAMEZOLE CHEMBL1255582 TdgClinicalTrial
ADRA2B 151 GUANFACINE CHEMBL862 agonist GuideToPharmacologyInteractions
ADRA2B 151 XYLAZINE CHEMBL297362 agonist GuideToPharmacologyInteractions
ADRA2B 151 CHEMBL362051 CHEMBL362051 antagonist GuideToPharmacologyInteractions
ADRA2B 151 PRAZOSIN CHEMBL2 antagonist GuideToPharmacologyInteractions
ADRA2B 151 RAUWOLSCINE CHEMBL10347 antagonist GuideToPharmacologyInteractions
ADRA2B 151 TERGURIDE CHEMBL73151 antagonist GuideToPharmacologyInteractions
ADRA2B 151 MEPHENTERMINE SULFATE CHEMBL1200996 agonist ChemblInteractions
ADRA2B 151 APRACLONIDINE HYDROCHLORIDE CHEMBL1200379 agonist ChemblInteractions
ADRA2B 151 ERGOLOID MESYLATES CHEMBL2311030 antagonist ChemblInteractions
ADRA2B 151 PHENOXYBENZAMINE HYDROCHLORIDE CHEMBL1200787 antagonist ChemblInteractions
ADRA2B 151 TOLAZOLINE HYDROCHLORIDE CHEMBL1689 antagonist ChemblInteractions
ADRA2B 151 DEXMEDETOMIDINE HYDROCHLORIDE CHEMBL2106195 agonist ChemblInteractions
ADRA2B 151 APRACLONIDINE CHEMBL647 agonist DrugBank 1676991
ADRA2B 151 ROTIGOTINE CHEMBL1303 antagonist DrugBank 18704368
ADRA2B 151 TOLAZOLINE CHEMBL770 antagonist, binder GuideToPharmacologyInteractions, DrugBank 9089664

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ADRA2B rs29000568 TCCTCCTCT/del + del/del clonidine efficacy no This SNP was not selected as a significant predictor of clonidine responsiveness within multiple logistic regression analysis. Responders were defined as those with a 20% decrease in body weight and a 20% increase in urine sodium volume after 3 months of treatment. Genotypes TCCTCCTCT/del + del/del are not associated with response to clonidine in people with Liver Cirrhosis as compared to genotype TCCTCCTCT/TCCTCCTCT. 20833658 982044507