PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSP90AA1	7	HSPA1L	2	affinity chromatography technology	Gano JJ (2010)	1
HSP90AB1	2	HSPA4	3	biochemical, affinity chromatography technology	Wan C (2015), Reidy M (2018)	2
STIP1	1	CCDC117	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Huttlin EL (2017)	4
OBSL1	9	HSP90AB1	2	affinity chromatography technology	Hanson D (2014)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
ELAVL1	0	CCDC117	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	STIP1	1	biochemical	Wan C (2015)	1
HSP90AB1	2	HSPA8	4	biochemical, affinity chromatography technology	Wan C (2015), Reidy M (2018)	2
HSPA8	4	HSPBP1	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Stelzl U (2005), Alberti S (2004), Taipale M (2014), Taipale M (2014), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	8
CCDC117	1	HSPA4	3	affinity chromatography technology	Huttlin EL (2015)	1
CCDC117	1	OBSL1	9	affinity chromatography technology	Huttlin EL (2015)	1
CCDC117	1	BAG1	1	affinity chromatography technology	Huttlin EL (2017)	1
CCDC117	1	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSPA4	3	HSPBP1	0	pull down, affinity chromatography technology, pull down	Oh WK (2003), Oh WK (2003), Graner MW (2009)	3
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
CCDC117	1	HSPBP1	0	affinity chromatography technology	Huttlin EL (2017)	1
STIP1	1	3323	0	affinity chromatography technology	Huttlin EL (2017)	1
RAB6B	2	CCDC117	1	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	CCDC117	1	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Huttlin EL (2017)	2
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
CCDC117	1	3323	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSP90AB1	2	CCDC117	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2015)	3
OBSL1	9	ELAVL1	0	affinity chromatography technology	Hanson D (2014)	1
HSP90AB1	2	STIP1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Chadli A (2008), Huttlin EL (2017)	8
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
STIP1	1	HSPA4	3	affinity chromatography technology, pull down, pull down, pull down, biochemical	Johnson BD (1998), Horibe T (2011), Brinker A (2002), Graumann K (2000), Wan C (2015)	5
HSPA8	4	STIP1	1	biochemical, far western blotting, pull down, pull down, pull down, biochemical	Havugimana PC (2012), Gebauer M (1998), Gebauer M (1998), Liu FH (1999), Tsukahara F (2000), Wan C (2015)	6
CCDC117	1	HSPA1L	2	affinity chromatography technology	Huttlin EL (2015)	1
BAG1	1	HSPA8	4	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, pull down, two hybrid, pull down, affinity chromatography technology	Takayama S (1997), Takayama S (1999), Takayama S (1999), Takayama S (1997), Takayama S (1997), Elliott E (2007), Alberti S (2002), Tsukahara F (2010), Brive L (2001), Lueders J (2000), Townsend PA (2003), Townsend PA (2003), Townsend PA (2004), Sharp A (2009), Sharp A (2009), Sondermann H (2001), Gebauer M (1998), Rolland T (2014), Mock JY (2015), Karras GI (2017)	20
BAG1	1	HSPA4	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Takayama S (1997), Kalia SK (2004), Gamerdinger M (2009), Gamerdinger M (2009), Lueders J (2000), Townsend PA (2003), Townsend PA (2003), Takahashi N (2001), Deeg S (2010), Song J (2001), Song J (2001)	11