PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH5	2	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	PPP2R1A	8	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	G3BP1	4	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	G3BP1	4	affinity chromatography technology	Yao Z (2017)	1
CDH1	4	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Hazan RB (1998), Shibata T (1994), Hinck L (1994), Knudsen KA (1992), Geng F (2012), Guo Z (2014)	7
GAN	4	CTNNA2	6	affinity chromatography technology	Johnson-Kerner BL (2015)	1
MCM2	3	CTNNA2	6	affinity chromatography technology	Drissi R (2015)	1
EGFR	5	CTNNA2	6	affinity chromatography technology	Li J (2013)	1
CTNNA2	6	JUP	7	biochemical	Wan C (2015)	1
MCM2	3	JUP	7	affinity chromatography technology	Drissi R (2015)	1
EGFR	5	PPP2R1A	8	affinity chromatography technology	Foerster S (2013)	1
JUP	7	CTNNBIP1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007)	2
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
FBXW11	2	CTNNA2	6	affinity chromatography technology	Coyaud E (2015)	1
G3BP1	4	CTNNA2	6	affinity chromatography technology	Jain S (2016)	1
CTNNBIP1	1	PPP2R1A	8	affinity chromatography technology	Ewing RM (2007)	1
CDH1	4	TES	1	bioid	Guo Z (2014)	1
NTRK1	1	CTNNB1	30	affinity chromatography technology	Emdal KB (2015)	1
SDHAF2	1	CTNNA2	6	affinity chromatography technology	Hein MY (2015)	1
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	CTNNA2	6	affinity chromatography technology	Emdal KB (2015)	1
CTNNA2	6	CTNNB1	30	biochemical	Wan C (2015)	1
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
EGFR	5	JUP	7	pull down, affinity chromatography technology, two hybrid, protein complementation assay	Hazan RB (1998), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014)	4
FBXL5	3	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
CTNNBIP1	1	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
CDH8	2	JUP	7	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	PPP2R1A	8	affinity chromatography technology	Emdal KB (2015)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
PAN2	3	JUP	7	affinity chromatography technology	Bett JS (2013)	1
CDH5	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lewalle JM (1997), Shasby DM (2002), Margariti A (2010), Cho T (2013), Huttlin EL (2017), Chang CC (2012), Chang CC (2012)	7
UBE2A	0	TES	1	affinity chromatography technology	An H (2017)	1
NTRK1	1	JUP	7	affinity chromatography technology	Emdal KB (2015)	1
CDH5	2	JUP	7	affinity chromatography technology, affinity chromatography technology	Lewalle JM (1997), Shasby DM (2002)	2
CIR1	1	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
PAN2	3	CTNNA2	6	affinity chromatography technology	Bett JS (2013)	1
G3BP1	4	PPP2R1A	8	affinity chromatography technology	Jain S (2016)	1
EGFR	5	CDH5	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CD27	1	CTNNA2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UTP3	0	CTNNA2	6	affinity chromatography technology	Huttlin EL (2015)	1
CTNNBIP1	1	CTNNB1	30	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Tago K (2000), Selbach M (2006), Daniels DL (2002), Chen Y (2016), Huttlin EL (2017)	6
SAPCD1	0	CTNNA2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	CTNNB1	30	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Schroeder JA (2002), Takahashi K (1997), Li J (2013)	4
CDH1	4	CTNNA2	6	bioid	Guo Z (2014)	1
DUSP22	1	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
SAPCD1	0	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP2R1A	8	CTNNA2	6	affinity chromatography technology	Fogeron ML (2013)	1
TES	1	CTNNA2	6	affinity chromatography technology	Sala S (2017)	1
CDH8	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Kido M (1998), Huttlin EL (2017)	2
TES	1	CTNNB1	30	affinity chromatography technology	Sala S (2017)	1
CDH8	2	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
UBE2A	0	CTNNA2	6	affinity chromatography technology	An H (2017)	1
MCM2	3	CTNNB1	30	affinity chromatography technology	Drissi R (2015)	1