PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BNIPL	9	BCL2	0	two hybrid, affinity chromatography technology	Qin W (2003), Qin W (2003)	2
BNIPL	9	GFER	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Shen L (2003), Shen L (2003), Shen L (2003), Wang J (2011)	4
BNIPL	9	BNIP2	0	two hybrid	Qin W (2003)	1
BNIPL	9	MIF	1	two hybrid, pull down, affinity chromatography technology, two hybrid	Shen L (2003), Shen L (2003), Shen L (2003), Wang J (2011)	4
BNIPL	9	PXDN	7	two hybrid	Wang J (2011)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
BCL2L1	0	FKBP8	1	affinity chromatography technology	Shirane M (2003)	1
BNIPL	9	BCL2L1	0	two hybrid	Qin W (2003)	1
BNIPL	9	FKBP8	1	two hybrid	Wang J (2011)	1
BNIPL	9	BNIPL	9	two hybrid, affinity chromatography technology	Qin W (2003), Qin W (2003)	2
BNIPL	9	SNAPIN	1	two hybrid	Wang J (2011)	1
BCL2	0	FKBP8	1	affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology	Shirane M (2003), Edlich F (2007), Kang CB (2005), Kang CB (2005), Edlich F (2005), Edlich F (2005), Edlich F (2005), Edlich F (2007), Edlich F (2007)	9
BNIPL	9	RECQL5	3	two hybrid	Wang J (2011)	1
BNIP2	0	BCL2	0	two hybrid, two hybrid, pull down	Qin W (2003), Boyd JM (1994), Boyd JM (1994)	3
BNIPL	9	PYCR1	3	two hybrid	Wang J (2011)	1
RHOU	0	BNIPL	9	pull down	Dart AE (2015)	1
BNIP2	0	ARHGAP1	0	pull down, pull down, two hybrid, affinity chromatography technology, pull down	Low BC (2000), Low BC (2000), Low BC (2000), Low BC (1999), Low BC (1999)	5
BNIPL	9	NME2	0	two hybrid	Wang J (2011)	1
BNIPL	9	ARHGAP1	0	two hybrid	Qin W (2003)	1