PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STAT5B	3	CTLA4	0	imaging technique	Chen TC (2014)	1
STAT5A	4	JAK2	1	affinity chromatography technology, two hybrid, pull down, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Fujitani Y (1997), Gouilleux F (1994)	4
CTLA4	0	CD86	2	x-ray crystallography, pull down, imaging technique	Schwartz JC (2001), Ramani SR (2012), Chen TC (2014)	3
CTLA4	0	CD80	0	pull down, x-ray crystallography, pull down, pull down	Peach RJ (1995), Stamper CC (2001), Ramani SR (2012), Ramani SR (2012)	4
CTLA4	0	PPP2R5A	2	affinity chromatography technology, two hybrid	Baroja ML (2002), Baroja ML (2002)	2
STAT5B	3	JAK2	1	affinity chromatography technology, two hybrid, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Varghese LN (2014)	3
LYN	2	JAK2	1	pull down	Chin H (1998)	1
ELAVL1	0	CTLA4	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	LYN	2	affinity chromatography technology	Abdelmohsen K (2009)	1
STAT5A	4	STAT5B	3	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	CTLA4	0	x-ray crystallography, affinity chromatography technology, pull down, two hybrid, x-ray crystallography	Follows ER (2001), Chuang E (1997), Chuang E (1997), Chuang E (1997), Owen DJ (1998)	5
CTLA4	0	LYN	2	affinity chromatography technology	Miyatake S (1998)	1
STAT5A	4	CTLA4	0	imaging technique	Chen TC (2014)	1
CD86	2	CD80	0	imaging technique	Chen TC (2014)	1
CTLA4	0	CTLA4	0	x-ray crystallography	Stamper CC (2001)	1
FYN	1	JAK2	1	affinity chromatography technology, pull down	Sayeski PP (1999), Sayeski PP (1999)	2
CTLA4	0	FYN	1	affinity chromatography technology, imaging technique	Miyatake S (1998), Chen TC (2014)	2
CTLA4	0	LCK	0	affinity chromatography technology	Miyatake S (1998)	1
CTLA4	0	JAK2	1	affinity chromatography technology	Chikuma S (2000)	1