PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
KIT 4 PIK3R1 6 two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique De Sepulveda P (1999), van Dijk TB (2000), Serve H (1994), Zhu MJ (2007), Zhu MJ (2007), Yokouchi M (1997), Chen TC (2014) 7
SHC1 0 HSP90AA1 7 affinity chromatography technology Brehme M (2009) 1
LYN 2 KIT 4 affinity chromatography technology, affinity chromatography technology, pull down Liang X (2002), Linnekin D (1997), Linnekin D (1997) 3
KIT 4 PIK3R2 3 two hybrid De Sepulveda P (1999) 1
PIK3R2 3 PIK3CA 8 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Brehme M (2009), Kuchay S (2013), Hein MY (2015) 3
SRC 2 FYN 1 unspecified method, affinity chromatography technology, affinity chromatography technology Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017) 3
GRB2 2 HSP90AA1 7 affinity chromatography technology Brehme M (2009) 1
PIK3R1 6 PIK3CA 8 pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe Woscholski R (1994), Chamberlain MD (2004), Ren SY (2005), Kamal M (2010), Sun M (2010), Hein MY (2015), Fang D (2001), Xiong Y (2009), Ivanov AA (2017) 9
LYN 2 CSF1R 0 affinity chromatography technology Li Y (1995) 1
SRC 2 PIK3R1 6 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique Burnham MR (1999), Song JJ (2010), Liu W (2010), Chen TC (2014) 4
GRAP2 0 CSF1R 0 pull down, imaging technique Bourette RP (1998), Chen TC (2014) 2
CSF1R 0 KIT 4 affinity chromatography technology, enzymatic study Tsujimura T (1999), Tsujimura T (1999) 2
HSP90AA1 7 YES1 1 affinity chromatography technology Taipale M (2012) 1
CBL 7 PIK3R2 3 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015) 7
ITGAV 7 CBL 7 affinity chromatography technology Elsegood CL (2006) 1
PIK3R2 3 SHC1 0 affinity chromatography technology, affinity chromatography technology Brehme M (2009), Brehme M (2009) 2
ITGAV 7 CSF1R 0 affinity chromatography technology Elsegood CL (2006) 1
CSF1R 0 GRB2 2 two hybrid, pull down, affinity chromatography technology Mancini A (1997), Mancini A (1997), Wang Y (1999) 3
HSP90AA1 7 LYN 2 affinity chromatography technology Taipale M (2012) 1
GRB2 2 PIK3R1 6 affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008) 18
SOCS3 0 CSF1R 0 affinity chromatography technology Hoertner M (2002) 1
YES1 1 FYN 1 affinity chromatography technology, affinity chromatography technology Piedra J (2003), Huttlin EL (2017) 2
CBL 7 GRB2 2 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017) 83
FYN 1 HSP90AA1 7 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017) 4
GRB2 2 SOCS1 1 pull down De Sepulveda P (1999) 1
STAP2 3 CBL 7 affinity chromatography technology, pull down, affinity chromatography technology Sekine Y (2009), Sekine Y (2009), Sekine Y (2007) 3
CSF1R 0 CTDSP1 0 two hybrid Yao Z (2017) 1
CSF1R 0 SOS1 5 affinity chromatography technology, affinity chromatography technology Wang Y (1999), Wang Y (1999) 2
SRC 2 LYN 2 unspecified method Pirozzi G (1997) 1
KIT 4 GRB2 2 two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down De Sepulveda P (1999), Thoemmes K (1999), Feng GS (1996), Sun J (2007), Zhu MJ (2007), Wollberg P (2003), Brizzi MF (1996) 7
CSF1R 0 SHC1 0 affinity chromatography technology Wang Y (1999) 1
PAN2 3 HSP90AA1 7 affinity chromatography technology Bett JS (2013) 1
CBL 7 CSF1R 0 two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Mancini A (2002), Mancini A (2002), Mancini A (2002), Wilhelmsen K (2002), Wilhelmsen K (2002), Wang Y (1999), Wang Y (1999), Tanaka S (1995), Ota J (2000), Ota J (2000) 10
CTDSP1 0 CTDSP2 1 affinity chromatography technology, affinity chromatography technology Huttlin EL (2015), Huttlin EL (2017) 2
SOS1 5 SHC1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Qian X (2000), Foehr ED (2000), Park RK (1999), Chin H (1997), Wang Y (1999), Brehme M (2009), Brizzi MF (1996), Yu WM (2006), Klint P (1995) 9
SOCS1 1 PIK3R1 6 two hybrid Grossmann A (2015) 1
PAN2 3 CSF1R 0 affinity chromatography technology Bett JS (2013) 1
CSF1R 0 SOCS1 1 two hybrid, affinity chromatography technology, pull down Bourette RP (2001), Bourette RP (2001), Bourette RP (2001) 3
GRB2 2 SHC1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995) 57
CBL 7 SRC 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Kassenbrock CK (2002), Rafiq K (2011), Rellahan BL (2003), Vantler M (2006), Shishido T (2000), Shishido T (2000), Song JJ (2010), Sanjay A (2006), Sanjay A (2006), Tanaka S (1995), Tanaka S (1995), Tanaka S (1995), Szymkiewicz I (2004), Hashimoto S (2006) 14
PAN2 3 YES1 1 affinity chromatography technology Bett JS (2013) 1
KIT 4 YES1 1 pull down van Dijk TB (2000) 1
YES1 1 SOCS3 0 two hybrid Rolland T (2014) 1
FYN 1 CBL 7 affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015) 27
CBL 7 SHC1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996) 9
SRC 2 KIT 4 unspecified method Wollberg P (2003) 1
SHC1 0 PIK3R1 6 pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Harrison-Findik D (1995), Ren SY (2005), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Lee DY (2010) 6
KIT 4 SOCS1 1 two hybrid, affinity chromatography technology De Sepulveda P (1999), De Sepulveda P (1999) 2
LYN 2 CBL 7 affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology Taher TE (2002), Dombrosky-Ferlan PM (1997), Kaabeche K (2004), Wu J (2008), Tanaka S (1995), Marcilla A (1995) 6
CBL 7 PIK3R1 6 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015) 61
CSF1R 0 PIK3R1 6 affinity chromatography technology, imaging technique Wang Y (1999), Chen TC (2014) 2
PIK3CA 8 CBL 7 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Sattler M (1997), Sattler M (1997), Chernock RD (2001), Chernock RD (2001), Brehme M (2009) 5
KIT 4 CBL 7 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Zeng S (2005), Brizzi MF (1996), Dong Y (2015) 3
CBL 7 SOS1 5 affinity chromatography technology Wang Y (1999) 1
PIK3R1 6 SOS1 5 imaging technique Chen TC (2014) 1
SRC 2 GRB2 2 affinity chromatography technology, affinity chromatography technology Wan KF (2003), Saci A (2002) 2
PIK3R2 3 PIK3R1 6 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017) 3
CSF1R 0 SRC 2 affinity chromatography technology Courtneidge SA (1993) 1
FYN 1 PIK3R1 6 pull down Kapeller R (1994) 1
HSP90AA1 7 CSF1R 0 affinity chromatography technology Taipale M (2012) 1
SOS1 5 FYN 1 pull down Park C (1998) 1
HSP90AA1 7 SRC 2 affinity chromatography technology, affinity chromatography technology Hutchison KA (1992), Tsutsumi S (2012) 2
ITGAV 7 SHC1 0 affinity chromatography technology Lee DY (2010) 1
FYN 1 SOCS1 1 pull down De Sepulveda P (1999) 1
PAN2 3 LYN 2 affinity chromatography technology Bett JS (2013) 1
FYN 1 CSF1R 0 pull down, pull down, affinity chromatography technology Courtneidge SA (1993), Courtneidge SA (1993), Courtneidge SA (1993) 3
GRAP2 0 CBL 7 biochemical, affinity chromatography technology, two hybrid Yankee TM (2003), Yankee TM (2003), Grossmann A (2015) 3
CSF1R 0 PIK3R2 3 pull down Gout I (1992) 1
GRB2 2 PIK3R2 3 two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Bandyopadhyay S (2010), Brehme M (2009), Brehme M (2009), Bisson N (2011) 4
CSF1R 0 CTDSP2 1 two hybrid Yao Z (2017) 1
SHC1 0 SRC 2 pull down Schueller AC (2008) 1
CSF1 2 CBL 7 affinity chromatography technology Pakuts B (2007) 1
CSF1R 0 PIK3CA 8 pull down, two hybrid Mancini A (1997), Mancini A (1997) 2
CSF1R 0 YES1 1 affinity chromatography technology Courtneidge SA (1993) 1
LYN 2 SHC1 0 affinity chromatography technology Ptasznik A (1995) 1
CSF1R 0 STAP2 3 affinity chromatography technology, pull down Ikeda O (2007), Ikeda O (2007) 2
FYN 1 PIK3R2 3 pull down Gout I (1992) 1
GRB2 2 PIK3CA 8 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Brehme M (2009), Bisson N (2011), Huttlin EL (2017) 3
GRB2 2 SOS1 5 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Blagoev B (2003), Liu SK (1998), Oneyama C (2002), Puil L (1994), Robinson A (1996), Li N (1993), Wong A (2002), Wong A (2002), Reif K (1994), DAngelo G (1999), Nel AE (1995), Pandey P (1995), Buday L (1994), Tong XK (2000), Park RK (1999), Okada S (1996), Okada S (1996), Okada S (1996), Germani A (1999), Park RK (1999), Chin H (1997), Saci A (2002), Sastry L (1997), Spivak-Kroizman T (1994), Ingham RJ (1996), Wang Y (1999), Chu J (1998), Brehme M (2009), Houtman JC (2006), Lao DH (2006), Bisson N (2011), Wang J (2011), Ng MY (2017), Huttlin EL (2017), Kapoor GS (2010), Saito T (2004), Klint P (1995) 37
KIT 4 PIK3CA 8 affinity chromatography technology Furitsu T (1993) 1
YES1 1 CBL 7 pull down Shishido T (2000) 1
CSF1R 0 CSF1R 0 enzymatic study Mancini A (1997) 1
CSF1R 0 CSF1 2 pull down Wang ZE (1993) 1