PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEP128	1	CYLD	2	bioid	Gupta GD (2015)	1
BCL10	0	UBE2N	1	pull down	Zhou H (2004)	1
TBK1	1	CYLD	2	affinity chromatography technology, imaging technique, affinity chromatography technology	Friedman CS (2008), Genin P (2015), Genin P (2015)	3
IKBKG	0	TBK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Fenner BJ (2010), Li S (2011), Wang L (2012), Wang L (2012), Ran Y (2016), Huttlin EL (2017)	7
GRIN2B	30	MIB2	7	affinity chromatography technology, pull down	Jurd R (2008), Jurd R (2008)	2
NUP58	0	MIB2	7	affinity chromatography technology	Huttlin EL (2017)	1
HIF1AN	0	MAP3K7	2	affinity chromatography technology	Rodriguez J (2016)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
CEP128	1	TBK1	1	bioid	Gupta GD (2015)	1
IKZF5	0	MIB2	7	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
XRCC5	5	CEP128	1	affinity chromatography technology	Hein MY (2015)	1
HIF1AN	0	MIB2	7	affinity chromatography technology	Rodriguez J (2016)	1
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
XRCC5	5	MIB2	7	affinity chromatography technology	Hein MY (2015)	1
MIB2	7	UBE2N	1	pull down	Li S (2011)	1
SRPK2	1	XRCC5	5	enzymatic study	Lipp JJ (2015)	1
TBK1	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Wang L (2012), Liu XY (2011), Liu S (2015), Fang R (2017), Zhang Q (2017)	7
CYLD	2	MIB2	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rajan N (2014), Rajan N (2014), Rajan N (2014)	3
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
HIF1AN	0	TBK1	1	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
UBE2U	0	MIB2	7	two hybrid	van Wijk SJ (2009)	1
MIB2	7	ACTA1	1	two hybrid, pull down	Takeuchi T (2003), Takeuchi T (2003)	2
NAF1	0	MIB2	7	affinity chromatography technology	Hein MY (2015)	1
CEP128	1	MIB2	7	bioid	Gupta GD (2015)	1
MIB2	7	IKBKG	0	affinity chromatography technology	Stempin CC (2011)	1
F9	0	MIB2	7	affinity chromatography technology	Huttlin EL (2017)	1
MIB2	7	BCL10	0	affinity chromatography technology, pull down, affinity chromatography technology	Stempin CC (2011), Stempin CC (2011), Stempin CC (2011)	3
SRPK2	1	MIB2	7	enzymatic study	Lipp JJ (2015)	1
MAVS	1	MIB2	7	affinity chromatography technology	Ye JS (2014)	1
JAG2	6	MIB2	7	pull down	Takeuchi T (2005)	1
IKZF1	2	MIB2	7	affinity chromatography technology	Huttlin EL (2017)	1
MIB2	7	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Stempin CC (2011), Stempin CC (2011)	2
IST1	0	MIB2	7	biochemical	Wan C (2015)	1
MIB2	7	TBK1	1	enzymatic study	Li S (2011)	1
MAP3K7	2	BCL10	0	affinity chromatography technology	Blonska M (2007)	1
MAP3K7	2	CYLD	2	affinity chromatography technology, affinity chromatography technology	Koga T (2008), Elliott PR (2016)	2
IKZF1	2	IKZF5	0	pull down, two hybrid, affinity chromatography technology	Perdomo J (2000), Perdomo J (2000), Huttlin EL (2017)	3
P2RY1	1	MIB2	7	affinity chromatography technology	Huttlin EL (2017)	1