PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NAE1	0	UBA3	0	two hybrid, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, biochemical, pull down, biochemical, biochemical, pull down, pull down, biochemical	Chen Y (2000), Chen Y (2000), Huang DT (2008), Huang DT (2007), Walden H (2003), Bohnsack RN (2003), Osaka F (1998), Havugimana PC (2012), Kristensen AR (2012), Huang DT (2004), Gong L (1999), Wan C (2015)	12
UBE2D2	0	UBE2F	1	biochemical	Wan C (2015)	1
DCUN1D2	0	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
DCUN1D2	0	CUL5	1	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
DCUN1D5	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
UBE2F	1	CUL1	7	enzymatic study	Siergiejuk E (2009)	1
DCUN1D5	0	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
DCUN1D1	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Wu K (2011), Bennett EJ (2010), Huang G (2011), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	16
UBE2D2	0	RNF7	0	two hybrid, pull down	Markson G (2009), Kershaw NJ (2014)	2
RC3H1	6	UBE2F	1	pull down	Zhang Q (2015)	1
DCUN1D3	1	CUL5	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	4
RC3H1	6	UBE2D2	0	pull down	Zhang Q (2015)	1
DCUN1D5	0	CUL5	1	pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	4
DCUN1D3	1	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Huang G (2014), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016), Zhang S (2016), Zhang S (2016)	8
UBE2F	1	DCUN1D2	0	pull down	Monda JK (2013)	1
CUL5	1	CUL1	7	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D5	0	UBE2F	1	pull down	Monda JK (2013)	1
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
ELAVL1	0	DCUN1D3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	UBE2F	1	affinity chromatography technology	Abdelmohsen K (2009)	1
DCUN1D1	0	CUL5	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
DCUN1D3	1	RNF7	0	affinity chromatography technology	Keuss MJ (2016)	1
CUL5	1	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2F	1	RNF7	0	x-ray crystallography, pull down, pull down, pull down	Stanley DJ (2012), Huang DT (2009), Wang X (2015), Zhou W (2017)	4
UBE2F	1	CUL5	1	enzymatic study, enzymatic study, affinity chromatography technology	Jaeger S (2012), Stanley DJ (2012), Zhou W (2017)	3
DCUN1D2	0	CUL1	7	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Monda JK (2013), Meyer-Schaller N (2009), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	5
DCUN1D1	0	DCUN1D2	0	affinity chromatography technology	Bennett EJ (2010)	1
RNF34	1	UBE2D2	0	pull down	McDonald ER (2004)	1
RNF7	0	CUL1	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ohta T (1999), Kawakami T (2001), Tan M (2010), Swaroop M (2001), Huang DT (2009), Kuang P (2016), Zhou W (2017)	7
NAE1	0	UBE2F	1	enzymatic study	Huang DT (2009)	1
UBA3	0	UBE2F	1	enzymatic study	Huang DT (2009)	1
UBE2F	1	RNF34	1	two hybrid	Markson G (2009)	1
S100A11	1	UBE2F	1	biochemical	Havugimana PC (2012)	1
RNF7	0	CUL5	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, enzymatic study, pull down, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ohta T (1999), Bennett EJ (2010), Tan M (2008), Kelsall IR (2013), Kelsall IR (2013), Zhou W (2014), Rolland T (2014), Huang DT (2009), Kim DY (2013), Kim DY (2013), Yu H (2011), Bulatov E (2015), Wang X (2015), Wang X (2015), Wang X (2015), Kershaw NJ (2014), Huttlin EL (2017), Kuang P (2016), Kuang P (2016), Zhou W (2017), Zhou W (2017)	21
UBE2F	1	DCUN1D1	0	pull down	Monda JK (2013)	1
UBE2F	1	DCUN1D3	1	pull down, x-ray crystallography	Monda JK (2013), Monda JK (2013)	2