PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DYNLL2	0	NEK9	1	affinity chromatography technology	Boldt K (2016)	1
DYNC1I1	1	DYNLT1	3	two hybrid	Diefenbach RJ (2002)	1
MCM2	3	EWSR1	2	affinity chromatography technology	Drissi R (2015)	1
KRAS	1	RAF1	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology, fluorescent resonance energy transfe	Li W (2000), Kiyono M (2000), Sui X (2009), Lito P (2012), Rajalingam K (2005), Zhu J (2005), Blaukat A (2000), So J (2015), Ji H (2016), Hart T (2015), Wang T (2017), Saito T (2004), Ivanov AA (2017)	13
8339	0	CIZ1	1	bioid	Lambert JP (2015)	1
HOMER3	0	DYNLL2	0	two hybrid	Rual JF (2005)	1
SFMBT1	0	DYNLL1	0	affinity chromatography technology	Hauri S (2016)	1
DYNC1I1	1	AMBRA1	7	affinity chromatography technology	Di Bartolomeo S (2010)	1
DCAF7	4	AMBRA1	7	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	DIABLO	2	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	CIZ1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
AMOT	6	DYNLL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hauri S (2013), Boldt K (2016)	3
DYNLL2	0	CIZ1	1	affinity chromatography technology	Boldt K (2016)	1
THAP10	0	DYNLL2	0	two hybrid	Rual JF (2005)	1
DYNLL1	0	MYO5A	17	pull down, pull down, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Lo KW (2001)	4
DYNLL1	0	BMF	0	pull down	Day CL (2004)	1
PPP1CB	9	CLINT1	1	affinity chromatography technology	Hein MY (2015)	1
DYNLL2	0	MTPAP	2	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	DIABLO	2	affinity chromatography technology	Boldt K (2016)	1
WWC1	5	DYNLL1	0	affinity chromatography technology	Hauri S (2013)	1
OFD1	3	DYNLL1	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015), Boldt K (2016)	4
DYNLL1	0	DYNC1I1	1	two hybrid, two hybrid, pull down, unspecified method, affinity chromatography technology	Diefenbach RJ (2002), Diefenbach RJ (2002), Lo KW (2001), Lo KW (2001), Di Bartolomeo S (2010)	5
DYNLL1	0	SECISBP2L	1	affinity chromatography technology	Hein MY (2015)	1
DYNLL2	0	SKAP1	0	two hybrid	Yu H (2011)	1
PAK1	2	DYNLL1	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Vadlamudi RK (2004), Wang J (2011)	7
DYNLL1	0	DYNLT1	3	affinity chromatography technology	Boldt K (2016)	1
MCM2	3	8339	0	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	SKP1	0	affinity chromatography technology	Drissi R (2015)	1
DYNLL2	0	CCDC36	1	two hybrid	Rolland T (2014)	1
MCM2	3	DYNLL1	0	affinity chromatography technology	Drissi R (2015)	1
DYNLL1	0	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
DYNC1I1	1	DYNC1I2	0	affinity chromatography technology	Huttlin EL (2017)	1
DLGAP1	6	DYNLL2	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000)	6
NRF1	2	DYNLL1	0	pull down, affinity chromatography technology, affinity chromatography technology	Herzig RP (2000), Herzig RP (2000), Boldt K (2016)	3
LCA5	1	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
DCAF7	4	DYRK1A	36	biochemical, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skurat AV (2004), Skurat AV (2004), Ritterhoff S (2010), Ritterhoff S (2010), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Miyata Y (2011), Varjosalo M (2013), Miyata Y (2014), Miyata Y (2014), Glenewinkel F (2016), Glenewinkel F (2016), Glenewinkel F (2016), Huttlin EL (2017), Boldt K (2016), Hauri S (2016)	18
DYNLL2	0	CLINT1	1	affinity chromatography technology	Boldt K (2016)	1
ZMYM4	4	DYNLL2	0	affinity chromatography technology	Hauri S (2016)	1
DYNLL2	0	RPGRIP1L	2	affinity chromatography technology	Boldt K (2016)	1
AMOT	6	OFD1	3	bioid	Couzens AL (2013)	1
DYNLL1	0	XIAP	0	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	BMF	0	pull down, affinity chromatography technology, two hybrid	Day CL (2004), Puthalakath H (2001), Rolland T (2014)	3
AMOT	6	DYNLL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Couzens AL (2013), Hauri S (2013), Boldt K (2016)	4
DYNLL1	0	CCDC36	1	two hybrid	Rolland T (2014)	1
LCA5	1	SSNA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
SHANK2	8	DYNLL1	0	affinity chromatography technology	Naisbitt S (2000)	1
DYNLL1	0	CLINT1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
WWC1	5	DYNLL2	0	affinity chromatography technology	Hauri S (2013)	1
DYNLL2	0	GPHN	1	affinity chromatography technology	Boldt K (2016)	1
SECISBP2L	1	DYNLL2	0	two hybrid	Rolland T (2014)	1
DYNLL2	0	TLK2	16	affinity chromatography technology	Boldt K (2016)	1
MEOX2	2	DYNLL2	0	two hybrid	Rolland T (2014)	1
EED	1	PCBP1	2	affinity chromatography technology	Cao Q (2014)	1
DYNLL1	0	SHMT2	3	affinity chromatography technology	Boldt K (2016)	1
DNAL4	0	DYNLL2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
LRFN4	2	DYNLL1	0	affinity chromatography technology	Huttlin EL (2017)	1
DYNLL1	0	PCBP1	2	biochemical	Wan C (2015)	1
G3BP1	4	DYNLL2	0	affinity chromatography technology	Jain S (2016)	1
SHMT2	3	FAM117B	3	affinity chromatography technology	Castello A (2012)	1
DYNLL1	0	DDHD1	3	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	PCBP1	2	biochemical	Wan C (2015)	1
DYNLL2	0	MORC3	5	affinity chromatography technology	Boldt K (2016)	1
GPRIN2	6	DYNLL2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SKP1	0	DYNLL1	0	affinity chromatography technology	Hauri S (2016)	1
MCM2	3	G3BP1	4	affinity chromatography technology	Drissi R (2015)	1
DYNLL1	0	FAM117B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	3
DYNLL1	0	DYNC1I2	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Hein MY (2015)	2
DYNLL1	0	RPGRIP1L	2	affinity chromatography technology	Boldt K (2016)	1
DYNC1I1	1	DYNLL2	0	two hybrid	Rual JF (2005)	1
DYRK1A	36	DYNLL1	0	affinity chromatography technology	Varjosalo M (2013)	1
SHMT2	3	RPGRIP1L	2	affinity chromatography technology	Castello A (2012)	1
8339	0	MORC3	5	bioid	Lambert JP (2015)	1
DYNLL2	0	SSNA1	0	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	ZMYM4	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016)	2
DYNLL1	0	DZANK1	3	affinity chromatography technology	Boldt K (2016)	1
MEOX2	2	MORN3	0	two hybrid	Rolland T (2014)	1
DYRK1A	36	DYNLL2	0	affinity chromatography technology	Varjosalo M (2013)	1
PPP1CB	9	MYO5A	17	affinity chromatography technology	Hein MY (2015)	1
SHANK2	8	DYNLL2	0	affinity chromatography technology	Naisbitt S (2000)	1
DYNLL2	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
DYNLL2	0	NRF1	2	affinity chromatography technology	Boldt K (2016)	1
MCM2	3	DYNLL2	0	affinity chromatography technology	Drissi R (2015)	1
DCAF7	4	PPP1CB	9	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
RPGRIP1L	2	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
DLGAP1	6	MYO5A	17	pull down	Naisbitt S (2000)	1
DYNLL2	0	RNF214	3	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	BCL2L11	4	pull down, affinity chromatography technology	Day CL (2004), Huttlin EL (2015)	2
DYNLL1	0	TLK2	16	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
DYNLT1	3	WDR34	2	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
DYNLL2	0	MORN3	0	two hybrid	Rolland T (2014)	1
8339	0	DYNLL2	0	bioid	Lambert JP (2015)	1
EWSR1	2	DYNLL2	0	two hybrid	Rual JF (2005)	1
DLGAP1	6	DLG4	11	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Takeuchi M (1997), Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Boeckers TM (1999), Wu H (2000), Kim E (1997), Kim E (1997), Kim E (1997), Kim E (1997)	11
MORC3	5	DYNLL1	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
DYNLL2	0	SHMT2	3	affinity chromatography technology	Boldt K (2016)	1
RAF1	3	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, imaging technique	Dogan T (2008), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Tian S (2006), Chen TC (2014)	7
DYNLL2	0	PAK1	2	two hybrid	Wang J (2011)	1
DYNLL2	0	DZANK1	3	affinity chromatography technology	Boldt K (2016)	1
DCAF7	4	SKP1	0	affinity chromatography technology	Boldt K (2016)	1
BMF	0	MYO5A	17	pull down	Puthalakath H (2001)	1
DLGAP1	6	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
DYNLL2	0	SKP1	0	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	WDR34	2	affinity chromatography technology	Boldt K (2016)	1
DYRK1A	36	FAM117B	3	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
DLGAP1	6	DYNLL1	0	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Lo KW (2001)	6
LRFN4	2	DYNLL2	0	affinity chromatography technology	Huttlin EL (2017)	1
DYNLL2	0	DYNC1I2	0	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	RNF214	3	affinity chromatography technology	Boldt K (2016)	1
RPGRIP1L	2	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
EED	1	DYNLL1	0	affinity chromatography technology	Cao Q (2014)	1
DYNLT1	3	DYNC1I2	0	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
CSNK1A1	1	DYNLL1	0	affinity chromatography technology	Varjosalo M (2013)	1
G3BP1	4	RNF214	3	affinity chromatography technology	Jain S (2016)	1
RASGRP3	3	DYNLL2	0	two hybrid	Rolland T (2014)	1
CSNK1A1	1	DYNLL2	0	affinity chromatography technology	Varjosalo M (2013)	1
LCA5	1	DYNLL2	0	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
DYNLL2	0	C12orf40	1	two hybrid	Rolland T (2014)	1
WDR60	4	WDR34	2	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	DYNLL2	0	x-ray crystallography	Day CL (2004)	1
DYNC1I1	1	WDR34	2	affinity chromatography technology	Huttlin EL (2017)	1
DYNLL2	0	AMBRA1	7	affinity chromatography technology	Boldt K (2016)	1
PCBP1	2	EWSR1	2	two hybrid	Lim J (2006)	1
SHANK2	8	DLG4	11	affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Boeckers TM (1999)	2
DYNLL1	0	MTPAP	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
DCAF7	4	DYNLL1	0	affinity chromatography technology	Boldt K (2016)	1
SFMBT1	0	DYNLL2	0	affinity chromatography technology	Hauri S (2016)	1
KRAS	1	DYNLL2	0	genetic interference	Luo J (2009)	1
KRAS	1	WWC1	5	genetic interference	Luo J (2009)	1
DYNLL2	0	PPP1CB	9	affinity chromatography technology	Boldt K (2016)	1
XIAP	0	DIABLO	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Hunter AM (2003), Davoodi J (2004), Song Z (2003), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2000), Verhagen AM (2002), Samuel T (2006), McNeish IA (2005), Yoon K (2004), Fu J (2003), Fu J (2003), Fu J (2003), Fu J (2003), Hu S (2003), Hao Y (2004), Sekine K (2005), Csomos RA (2009), Bartke T (2004), Burke SP (2010), Burke SP (2010), Vucic D (2002), Qiu XB (2005), Qiu XB (2005), Scott FL (2005), Srinivasula SM (2001), Martins LM (2002), Kulathila R (2009), Huang Y (2001), Chai J (2001), Liu Z (2001), Liu Z (2001), Gao Z (2007), Davoodi J (2007), Hegde R (2002), Krieg A (2009), Huang Y (2003), Huang Y (2003), Arnt CR (2002), Damgaard RB (2013), Lee S (2014), Hao Y (2004), Hao Y (2004), Masoumi KC (2012), Guvenc H (2013), Buetow L (2015), Wo L (2016), Huttlin EL (2017), Wu G (2001), Wu G (2001), Hou Y (2017)	52
DYNLL2	0	OFD1	3	affinity chromatography technology	Boldt K (2016)	1
DYNLL2	0	DYNLT1	3	affinity chromatography technology	Boldt K (2016)	1
EWSR1	2	AMOT	6	bioid	Elzi DJ (2014)	1
AMOT	6	WWC1	5	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Toloczko A (2017)	3
NEK9	1	DYNLL1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), So J (2015), Hein MY (2015), Boldt K (2016)	4
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
MCM2	3	PCBP1	2	affinity chromatography technology	Drissi R (2015)	1
XIAP	0	DYNLL2	0	two hybrid, affinity chromatography technology	Rual JF (2005), Boldt K (2016)	2
EED	1	SKP1	0	affinity chromatography technology	Cao Q (2014)	1
LCA5	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
DYNLL2	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	WDR34	2	affinity chromatography technology	Boldt K (2016)	1
EED	1	DYNLL2	0	affinity chromatography technology	Cao Q (2014)	1
DYNLL1	0	DYNLL2	0	biochemical, affinity chromatography technology	Wan C (2015), Boldt K (2016)	2
DLGAP1	6	SHANK2	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Naisbitt S (2000), Naisbitt S (2000), Boeckers TM (1999), Boeckers TM (1999), Boeckers TM (1999)	5
SHANK2	8	MYO5A	17	affinity chromatography technology	Naisbitt S (2000)	1
HMBOX1	2	DYNLL2	0	two hybrid	Rolland T (2014)	1
DYNLL1	0	RAF1	3	affinity chromatography technology	Boldt K (2016)	1
PCBP1	2	SKP1	0	affinity chromatography technology	Zhang MP (2017)	1
FAM117B	3	DYNLL2	0	affinity chromatography technology	Boldt K (2016)	1
PAK1	2	RAF1	3	affinity chromatography technology, pull down, enzymatic study	Zang M (2002), Zang M (2002), Zang M (2002)	3
DYNLL1	0	GPHN	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
AMBRA1	7	DYNLL1	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Di Bartolomeo S (2010), Di Bartolomeo S (2010), Boldt K (2016)	3
DYNLL2	0	DDHD1	3	affinity chromatography technology	Boldt K (2016)	1
DYNLL1	0	DLG4	11	pull down, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000)	2
DYNLL2	0	MYO5A	17	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Naisbitt S (2000), Puthalakath H (2001)	5
DYNLL1	0	BCL2L11	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Day CL (2004), Vadlamudi RK (2004), Lei K (2003), Huttlin EL (2015)	4
DYNLL2	0	WDR60	4	affinity chromatography technology	Boldt K (2016)	1
LCA5	1	DYNLL1	0	affinity chromatography technology	Gupta GD (2015)	1
DYNLT1	3	WDR60	4	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
EED	1	PPP1CB	9	affinity chromatography technology	Cao Q (2014)	1
DCAF7	4	DYNLL2	0	affinity chromatography technology	Boldt K (2016)	1
FAM117B	3	DCAF7	4	affinity chromatography technology	Boldt K (2016)	1
DYNLT1	3	CIZ1	1	bioid	Gupta GD (2015)	1