PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CRX	0	BANF1	0	two hybrid, pull down	Wang X (2002), Wang X (2002)	2
CRX	0	KLHL32	2	two hybrid	Rolland T (2014)	1
CRX	0	PRKCI	1	affinity chromatography technology	Waaijers S (2013)	1
CRX	0	M1AP	0	two hybrid	Rual JF (2005)	1
AES	2	ABI2	4	two hybrid	Rolland T (2014)	1
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
CRX	0	EIF5A	1	two hybrid	Rolland T (2014)	1
PRKN	1	CRX	0	two hybrid	Corominas R (2014)	1
CRX	0	C1orf109	1	two hybrid	Rolland T (2014)	1
EP300	36	CRX	0	two hybrid	Yanagi Y (2000)	1
CRX	0	SP1	0	affinity chromatography technology	Lerner LE (2005)	1
CRX	0	SFI1	3	two hybrid	Rolland T (2014)	1
CRX	0	PPP1R16B	2	two hybrid	Rolland T (2014)	1
CRX	0	ATG12	1	two hybrid	Rolland T (2014)	1
SP4	4	SP1	0	genetic interference	Hagen G (1995)	1
CRX	0	NRL	0	fluorescent resonance energy transfe	von Alpen D (2015)	1
RBFOX1	1	CRX	0	two hybrid	Corominas R (2014)	1
CRX	0	KIAA0141	0	two hybrid	Rolland T (2014)	1
CRX	0	SP3	4	affinity chromatography technology	Lerner LE (2005)	1
AES	2	SOX5	11	two hybrid	Rolland T (2014)	1
CRX	0	PSMB10	0	two hybrid	Rolland T (2014)	1
SP4	4	SP3	4	genetic interference	Hagen G (1995)	1
CRX	0	IPO13	6	pull down	Ploski JE (2004)	1
CRX	0	UBXN2B	2	two hybrid	Rolland T (2014)	1
MDFI	1	PID1	0	two hybrid	Rolland T (2014)	1
CCNC	0	CRX	0	two hybrid	Rolland T (2014)	1
CRX	0	GUCD1	0	two hybrid	Rolland T (2014)	1
CRX	0	SOX5	11	two hybrid	Rolland T (2014)	1
CRX	0	CSNK1G2-AS1	0	two hybrid	Rolland T (2014)	1
CRX	0	C9orf72	0	two hybrid	Rolland T (2014)	1
PRKAB2	0	CRX	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
CRX	0	NIP7	2	two hybrid	Rolland T (2014)	1
MDFI	1	SFI1	3	two hybrid	Rual JF (2005)	1
CRX	0	GCM2	3	two hybrid	Rolland T (2014)	1
ATXN7	0	CRX	0	two hybrid, affinity chromatography technology, pull down	La Spada AR (2001), La Spada AR (2001), Palhan VB (2005)	3
CRX	0	SP4	4	affinity chromatography technology, affinity chromatography technology	Lerner LE (2005), Lerner LE (2005)	2
NR2E3	2	CRX	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
NR2E3	2	NRL	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	von Alpen D (2015), von Alpen D (2015)	2
CRX	0	KAT2A	1	pull down	Palhan VB (2005)	1
AES	2	STK16	1	two hybrid	Rolland T (2014)	1
CRX	0	MDFI	1	two hybrid	Rual JF (2005)	1
CRX	0	MLLT6	2	two hybrid	Rolland T (2014)	1
ATXN7	0	EP300	36	affinity chromatography technology	Palhan VB (2005)	1
CRX	0	STK16	1	two hybrid	Rolland T (2014)	1
CRX	0	PID1	0	two hybrid	Rolland T (2014)	1
CRX	0	ROR2	0	two hybrid	Rolland T (2014)	1
AES	2	C1orf109	1	two hybrid	Rolland T (2014)	1
CRX	0	SZT2	12	two hybrid	Rolland T (2014)	1
CA8	0	CRX	0	two hybrid	Rolland T (2014)	1
CRX	0	QRICH1	8	two hybrid	Rolland T (2014)	1
MDFI	1	ATG12	1	two hybrid	Rual JF (2005)	1
AES	2	OSGIN1	1	two hybrid	Rolland T (2014)	1
EP300	36	SP3	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Choi HS (2002), Walker GE (2001)	3
PRKAB2	0	MDFI	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
SP3	4	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Goto T (2006), Goto T (2006), Choi HS (2002), Choi HS (2002), Walker GE (2001), Walker GE (2001), Xu Q (2000), Tang S (2004), Kwon JH (2003), Syddall CM (2013), Syddall CM (2013), Syddall CM (2013)	12
ATXN7	0	KAT2A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Y (2008), Helmlinger D (2006), Palhan VB (2005), Demeny MA (2007), Janer A (2010)	5
AES	2	CRX	0	two hybrid	Rolland T (2014)	1
CRX	0	LARP4	1	two hybrid	Rolland T (2014)	1
CRX	0	OSGIN1	1	two hybrid	Rolland T (2014)	1
EP300	36	NPAS2	0	pull down, pull down	Curtis AM (2004), Curtis AM (2004)	2
MDFI	1	CSNK1G2-AS1	0	two hybrid	Rolland T (2014)	1
NPAS2	0	CRX	0	two hybrid	Corominas R (2014)	1
CRX	0	LONRF1	4	two hybrid	Rolland T (2014)	1
CRX	0	ABI2	4	two hybrid	Rolland T (2014)	1