Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CREB1	1385	NICOTINE	CHEMBL3		NCI	11331423
CREB1	1385	ADENOSINE PHOSPHATE	CHEMBL752	activator	DrugBank	17324065, 17300755, 16879221, 17083486, 17122581
CREB1	1385	ALCOHOL	CHEMBL545		NCI	11181917

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CREB1	rs889895	GG	antidepressants	efficacy	yes	Subjects with the GG genotype are more likely to show remission. Non-remitters were defined as having a Hamilton Depression Rating Scale (HDRS) score of > 7 after at least one adequate antidepressant trial during the current or most recent depressive episode. No significant differences were seen when considering patients' resistance or responsiveness (please see paper for definitions of these).	Genotype GG is associated with increased response to antidepressants in people with Depressive Disorder, Major as compared to genotypes AA + AG.	23537502	1183703910
CREB1	rs889895	A	antidepressants	efficacy	no	Patients with major depressive disorder OR bipolar disorder. No significant difference in allele or genetoype frequencies were seen between patients who were or were not resistant, responsive or entered remission while taking antidepressants. Please refer to paper for definitions of a resistant, response and remittent patient.	Allele A is not associated with response to antidepressants in people with Mental Disorders as compared to allele G.	23537502	1183704054
CREB1	rs6740584	C	antidepressants	efficacy	no	Or people with major depressive disorder OR bipolar disorder. No significant difference in allele or genetoype frequencies were seen between patients who were or were not resistant, responsive or entered remission while taking antidepressants. Please refer to paper for definitions of a resistant, response and remittent patient. Also note that initial analyses showed that patients with major depressive disorder or bipolar disorder and the C allele were more likely to be non-resistant and responsive, but adding covariates (socio-demographic and clinical) to the association led to non-significant p-values.	Allele C is not associated with response to antidepressants in people with Depressive Disorder, Major as compared to allele T.	23537502	1183704043