Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ADORA2A 135 V81444 CHEMBL3545288 antagonist ChemblInteractions
ADORA2A 135 APADENOSON CHEMBL1950649 agonist GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 16524538
ADORA2A 135 ADENOSINE CHEMBL477 agonist GuideToPharmacologyInteractions, ChemblInteractions
ADORA2A 135 DYPHYLLINE CHEMBL1752 antagonist DrugBank 2997628
ADORA2A 135 THEOBROMINE CHEMBL1114 antagonist DrugBank 17558310, 17577101, 12602592, 17616786, 3588607, 15095008
ADORA2A 135 BINODENOSON CHEMBL1950554 agonist GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 16524538, 17531571
ADORA2A 135 REGADENOSON CHEMBL317052 agonist GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 22130964
ADORA2A 135 AMP579 CHEMBL3545163 agonist ChemblInteractions
ADORA2A 135 UK432097 CHEMBL1096896 agonist ChemblInteractions
ADORA2A 135 TOZADENANT CHEMBL2105747 antagonist GuideToPharmacologyInteractions, ChemblInteractions
ADORA2A 135 ISTRADEFYLLINE CHEMBL431770 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TTD
ADORA2A 135 ROLOFYLLINE (CHEMBL52333) CHEMBL52333 antagonist TTD
ADORA2A 135 PRELADENANT CHEMBL240624 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TTD
ADORA2A 135 CAFFEINE CHEMBL113 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
ADORA2A 135 CHEMBL57997 CHEMBL57997 antagonist TTD
ADORA2A 135 CAFFEINE, CITRATED CHEMBL1200569 antagonist ChemblInteractions
ADORA2A 135 CF102 CHEMBL431733 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL175543 CHEMBL175543 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL609245 CHEMBL609245 agonist GuideToPharmacologyInteractions
ADORA2A 135 N6-CYCLOPENTYLADENOSINE CHEMBL68738 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL2094089 CHEMBL2094089 agonist GuideToPharmacologyInteractions
ADORA2A 135 (R)-PIA CHEMBL139000 agonist GuideToPharmacologyInteractions
ADORA2A 135 (S)-PIA CHEMBL420705 agonist GuideToPharmacologyInteractions
ADORA2A 135 CGS-15943 CHEMBL16687 antagonist GuideToPharmacologyInteractions
ADORA2A 135 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] CHEMBL183 antagonist GuideToPharmacologyInteractions
ADORA2A 135 FK453 CHEMBL440115 antagonist GuideToPharmacologyInteractions
ADORA2A 135 FLAVONE CHEMBL275638 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL302765 CHEMBL302765 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL89852 CHEMBL89852 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL111545 CHEMBL111545 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL136689 CHEMBL136689 antagonist GuideToPharmacologyInteractions
ADORA2A 135 IMISOPASEM MANGANESE CHEMBL3544979 antagonist GuideToPharmacologyInteractions
ADORA2A 135 XANTHINE AMINE CONGENER CHEMBL273094 antagonist GuideToPharmacologyInteractions
ADORA2A 135 EVODENOSON CHEMBL1950651 agonist ChemblInteractions
ADORA2A 135 AMINOPHYLLINE CHEMBL1370561 antagonist ChemblInteractions
ADORA2A 135 SONEDENOSON CHEMBL1950553 agonist ChemblInteractions, TTD
ADORA2A 135 DEXEFAROXAN CHEMBL1357517 agonist TTD
ADORA2A 135 CHEMBL257833 CHEMBL257833 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL410873 CHEMBL410873 agonist GuideToPharmacologyInteractions
ADORA2A 135 CGS-21680 CHEMBL331372 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL298235 CHEMBL298235 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL2311146 CHEMBL2311146 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL76128 CHEMBL76128 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL74505 CHEMBL74505 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL309566 CHEMBL309566 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL449090 CHEMBL449090 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL74975 CHEMBL74975 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL1562432 CHEMBL1562432 antagonist GuideToPharmacologyInteractions
ADORA2A 135 VISNAGIN CHEMBL45176 antagonist GuideToPharmacologyInteractions
ADORA2A 135 DEFIBROTIDE CHEMBL2108396 DrugBank 8405101
ADORA2A 135 ZM-241385 CHEMBL113142 antagonist GuideToPharmacologyInteractions, DrugBank 10592235
ADORA2A 135 TONAPOFYLLINE CHEMBL414157 antagonist GuideToPharmacologyInteractions, TTD
ADORA2A 135 VIPADENANT CHEMBL447664 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TTD
ADORA2A 135 GR-79236 CHEMBL2163568 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL1256672 CHEMBL1256672 agonist GuideToPharmacologyInteractions
ADORA2A 135 METRIFUDIL CHEMBL331382 agonist GuideToPharmacologyInteractions
ADORA2A 135 GALANGIN CHEMBL309490 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL27508 CHEMBL27508 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL2181965 CHEMBL2181965 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL375293 CHEMBL375293 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL219160 CHEMBL219160 antagonist GuideToPharmacologyInteractions
ADORA2A 135 MORIN CHEMBL28626 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL76273 CHEMBL76273 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL75590 CHEMBL75590 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL273807 CHEMBL273807 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL75772 CHEMBL75772 antagonist GuideToPharmacologyInteractions
ADORA2A 135 SAKURANETIN CHEMBL448297 antagonist GuideToPharmacologyInteractions
ADORA2A 135 [3H]-ZM-241385 CHEMBL1628684 antagonist GuideToPharmacologyInteractions
ADORA2A 135 PENTOXIFYLLINE CHEMBL628 antagonist ChemblInteractions, DrugBank 19997047
ADORA2A 135 PBF-999 CHEMBL3545271 antagonist ChemblInteractions
ADORA2A 135 THEOPHYLLINE SODIUM GLYCINATE CHEMBL1200578 antagonist ChemblInteractions
ADORA2A 135 PBF-509 CHEMBL3545009 antagonist ChemblInteractions
ADORA2A 135 BVT.115959 CHEMBL3545409 agonist ChemblInteractions
ADORA2A 135 GW493838 CHEMBL3545223 agonist TTD
ADORA2A 135 ST1535 CHEMBL197669 antagonist GuideToPharmacologyInteractions, ChemblInteractions
ADORA2A 135 CHEMBL260563 CHEMBL260563 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL1895774 CHEMBL1895774 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL1234624 CHEMBL1234624 agonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL285819 CHEMBL285819 agonist GuideToPharmacologyInteractions
ADORA2A 135 GRAPIPRANT CHEMBL3039498 agonist GuideToPharmacologyInteractions
ADORA2A 135 NECA CHEMBL464859 agonist GuideToPharmacologyInteractions
ADORA2A 135 GS 6201 CHEMBL260933 antagonist GuideToPharmacologyInteractions
ADORA2A 135 Derenofylline CHEMBL592435 antagonist GuideToPharmacologyInteractions
ADORA2A 135 CHEMBL72862 CHEMBL72862 antagonist GuideToPharmacologyInteractions
ADORA2A 135 ROLOFYLLINE (CHEMBL2103819) CHEMBL2103819 antagonist GuideToPharmacologyInteractions
ADORA2A 135 ENPROFYLLINE CHEMBL279898 DrugBank 10496952
ADORA2A 135 THEOPHYLLINE CHEMBL190 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 3588607, 16357952
ADORA2A 135 OXTRIPHYLLINE CHEMBL1200434 antagonist ChemblInteractions, DrugBank 3588607, 16357952

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ADORA2A rs5751876 T methotrexate efficacy yes although not significant after Bonferroni correction. Allele T is associated with decreased response to methotrexate in people with Arthritis, Rheumatoid. 19902562 769173642
ADORA2A rs5751862 A regadenoson efficacy no as measured by change in heart rate and blood pressure or incidence of side effects. Allele A is not associated with response to regadenoson as compared to allele G. 28358597 1448612534