PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PSMD9	0	PSMD14	3	biochemical, affinity chromatography technology	Wan C (2015), Sun S (2017)	2
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
NUDCD2	2	PXN	1	biochemical	Havugimana PC (2012)	1
NPHP4	10	NUDCD2	2	bioid	Gupta GD (2015)	1
NUDCD2	2	ZPR1	1	biochemical	Havugimana PC (2012)	1
SORD	2	TPM1	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	PEX19	2	biochemical	Havugimana PC (2012)	1
SEC23IP	3	XIAP	0	biochemical	Havugimana PC (2012)	1
IGBP1	1	SMS	1	affinity chromatography technology	Hein MY (2015)	1
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
RPGR	0	NUDCD2	2	bioid	Gupta GD (2015)	1
CEP104	4	NUDCD2	2	bioid	Gupta GD (2015)	1
SMS	1	SORD	2	biochemical	Kristensen AR (2012)	1
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
NUDCD2	2	TTC1	3	biochemical	Havugimana PC (2012)	1
CEP104	4	HERC2	9	bioid	Gupta GD (2015)	1
NUDCD2	2	UBA3	0	biochemical	Havugimana PC (2012)	1
MKS1	3	NUDCD2	2	bioid	Gupta GD (2015)	1
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
SIRT1	3	HERC2	9	affinity chromatography technology, affinity chromatography technology	Bai B (2016), Bai B (2016)	2
PRMT5	3	STUB1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, protein complementation assay	Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016), Zhang HT (2016)	5
IGBP1	1	NUDCD2	2	biochemical	Havugimana PC (2012)	1
PSMD14	3	STUB1	4	biochemical	Havugimana PC (2012)	1
NUDCD2	2	PAFAH1B1	3	affinity chromatography technology	Yang Y (2010)	1
ACD	1	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
HERC2	9	HERC3	0	affinity chromatography technology	Huttlin EL (2015)	1
SIRT1	3	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Lin Z (2012), Hein MY (2015)	2
NUDCD2	2	PDRG1	1	biochemical	Havugimana PC (2012)	1
SSU72	0	PTGES3	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	SMARCD2	1	biochemical	Havugimana PC (2012)	1
EVC2	5	STUB1	4	bioid	Gupta GD (2015)	1
IGBP1	1	GINS4	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	PSMD9	0	biochemical	Havugimana PC (2012)	1
POT1	2	STUB1	4	two hybrid	Lee OH (2011)	1
NUDCD2	2	ZNF593	1	biochemical	Havugimana PC (2012)	1
PTGES3	0	STUB1	4	affinity chromatography technology	Schuelke JP (2010)	1
TINF2	1	STUB1	4	two hybrid	Lee OH (2011)	1
STIL	3	STUB1	4	bioid	Gupta GD (2015)	1
NUDCD2	2	PTGES3	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	PSMB7	1	biochemical	Havugimana PC (2012)	1
NUDCD2	2	SEC23IP	3	biochemical	Havugimana PC (2012)	1
HERC3	0	NUDCD2	2	affinity chromatography technology	Huttlin EL (2017)	1
SIRT1	3	SMARCD2	1	biochemical	Havugimana PC (2012)	1
NUDCD2	2	PTMS	2	biochemical	Havugimana PC (2012)	1
IGBP1	1	PXN	1	biochemical	Havugimana PC (2012)	1
SORD	2	NUDCD2	2	biochemical	Havugimana PC (2012)	1
TERF1	1	PRMT5	3	affinity chromatography technology	Giannone RJ (2010)	1
HERC2	9	SEC23IP	3	affinity chromatography technology	Al-Hakim AK (2012)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
NUDCD2	2	RNF114	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	DDX3Y	0	affinity chromatography technology	Huttlin EL (2017)	1
EVC2	5	TTC1	3	bioid	Gupta GD (2015)	1
STIL	3	NUDCD2	2	bioid	Gupta GD (2015)	1
POT1	2	DDX3Y	0	affinity chromatography technology	Giannone RJ (2010)	1
HSP90AA1	7	NEK8	3	affinity chromatography technology	Taipale M (2012)	1
NUDCD2	2	USP9X	15	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	PTGES3	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down	McLaughlin SH (2002), Mollapour M (2010), Kovacs JJ (2005), Giommarelli C (2010), Tsutsumi S (2012), Lee YT (2004), Schuelke JP (2010), Sarkar S (2012), Gano JJ (2010), Zelin E (2012), Obermann WM (1998), Wang J (2011), Weaver AJ (2000), Donze O (2001), Shimamura T (2012), Chan CT (2008), Chan CT (2008), Graumann K (2000), Martinez-Yamout MA (2006), Chadli A (2010), Woo SH (2009), Woo SH (2009), Woo SH (2009), Ni L (2010), Chadli A (2008), Picard D (2006), Wochnik GM (2004), Woodford MR (2016), Scholz GM (2001), McLaughlin SH (2006), Sun L (2012), Woodford MR (2016), Lepvrier E (2015)	33
PSMB7	1	PSMD14	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Wang X (2007)	2
HSP90AA1	7	PRMT5	3	affinity chromatography technology	Maloney A (2007)	1
TINF2	1	NUDCD2	2	two hybrid	Lee OH (2011)	1
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
NUDCD2	2	653505	0	biochemical	Havugimana PC (2012)	1
SEC23IP	3	SSU72	0	biochemical	Havugimana PC (2012)	1
HERC2	9	NUDCD2	2	affinity chromatography technology	Galligan JT (2015)	1
SMS	1	XIAP	0	affinity chromatography technology	Hein MY (2015)	1
IGBP1	1	USP9X	15	biochemical	Havugimana PC (2012)	1
STMN1	0	NUDCD2	2	biochemical	Wan C (2015)	1
PPIL3	0	GINS4	0	biochemical	Havugimana PC (2012)	1
TERF1	1	STUB1	4	affinity chromatography technology, two hybrid	Giannone RJ (2010), Lee OH (2011)	2
NUDCD2	2	PLP2	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	SSU72	0	biochemical	Havugimana PC (2012)	1
TERF1	1	USP9X	15	affinity chromatography technology	Giannone RJ (2010)	1
NUDCD2	2	PSMD14	3	biochemical	Havugimana PC (2012)	1
NUDCD2	2	TPM1	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	HSP90AA1	7	affinity chromatography technology	Yang Y (2010)	1
NUDCD2	2	OSTF1	2	biochemical	Havugimana PC (2012)	1
SEC23IP	3	ZNF593	1	biochemical	Havugimana PC (2012)	1
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
SMS	1	PDRG1	1	affinity chromatography technology	Hein MY (2015)	1
NUDCD2	2	SRSF2	0	biochemical	Havugimana PC (2012)	1
TPM1	0	STUB1	4	biochemical	Kristensen AR (2012)	1
NUDCD2	2	NUP210	9	biochemical	Havugimana PC (2012)	1
NUDCD2	2	PPIL3	0	biochemical	Havugimana PC (2012)	1
PSMD14	3	HERC2	9	affinity chromatography technology, affinity chromatography technology	Jacobson AD (2014), Jacobson AD (2014)	2
NPHP4	10	HSP90AA1	7	bioid	Gupta GD (2015)	1
IGBP1	1	PPIL3	0	biochemical	Havugimana PC (2012)	1
NUDCD2	2	XIAP	0	biochemical	Havugimana PC (2012)	1
ACD	1	STUB1	4	two hybrid	Lee OH (2011)	1
NUDCD2	2	SMS	1	biochemical	Havugimana PC (2012)	1
NUDCD2	2	GINS4	0	biochemical	Havugimana PC (2012)	1
NEK8	3	NUDCD2	2	bioid	Gupta GD (2015)	1
ACD	1	NUDCD2	2	two hybrid	Lee OH (2011)	1
PAFAH1B1	3	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology	Zhu XJ (2010), Zhu XJ (2010), Yang Y (2010)	3
NUDCD2	2	RPS21	0	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	TTC1	3	affinity chromatography technology	Hein MY (2015)	1
TERF1	1	NUDCD2	2	two hybrid	Lee OH (2011)	1
NUDCD2	2	PRMT5	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
NUDCD2	2	STUB1	4	biochemical	Havugimana PC (2012)	1
NEK8	3	TTC1	3	bioid	Gupta GD (2015)	1
HSP90AA1	7	PDRG1	1	affinity chromatography technology	Skarra DV (2011)	1
NUDCD2	2	SIRT1	3	biochemical	Havugimana PC (2012)	1
RNF114	0	HSP90AA1	7	biochemical	Bijlmakers MJ (2011)	1
EVC2	5	NUDCD2	2	bioid	Gupta GD (2015)	1
RPGR	0	NPHP4	10	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Huttlin EL (2017), Boldt K (2016)	3
POT1	2	NUDCD2	2	two hybrid	Lee OH (2011)	1