PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZFP64	4	ZBTB9	0	two hybrid	Ravasi T (2010)	1
PPARGC1B	2	PPARA	1	pull down	Lin J (2002)	1
ZFP64	4	ZNF513	2	two hybrid	Ravasi T (2010)	1
ZNF513	2	PPARGC1B	2	two hybrid	Ravasi T (2010)	1
SYVN1	2	PPARGC1B	2	affinity chromatography technology	Fujita H (2015)	1
PIAS1	4	NR1H2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2012), Zhang Y (2012), Lee JH (2016)	3
ESR1	0	DNAJC10	3	affinity chromatography technology	Dhamad AE (2016)	1
ESR1	0	PIAS1	4	two hybrid	Kobayashi S (2004)	1
TRIM25	5	PPARGC1B	2	affinity chromatography technology	Choudhury NR (2017)	1
PPARGC1B	2	FOXA2	3	affinity chromatography technology	Wolfrum C (2006)	1
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
PNKD	2	PPARGC1B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZFP64	4	PPARGC1B	2	two hybrid	Ravasi T (2010)	1
PPARG	0	ZBTB9	0	two hybrid	Ravasi T (2010)	1
ZNF200	0	PPARGC1B	2	two hybrid	Ravasi T (2010)	1
PPARGC1B	2	HNF4A	2	pull down	Lin J (2002)	1
PPARGC1B	2	ZBTB9	0	two hybrid	Ravasi T (2010)	1
HNRNPL	3	ZFP64	4	affinity chromatography technology	Fei T (2017)	1
PIAS1	4	PPARGC1B	2	affinity chromatography technology, affinity chromatography technology	Zhang Y (2012), Zhang Y (2012)	2
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
PPARGC1B	2	THRB	1	pull down	Lin J (2002)	1
HNRNPL	3	PPARA	1	affinity chromatography technology	Fei T (2017)	1
ZNF212	1	PPARGC1B	2	two hybrid	Ravasi T (2010)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
HNRNPL	3	THRB	1	affinity chromatography technology	Fei T (2017)	1
SRC	2	ESR1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, imaging technique, imaging technique, imaging technique, pull down, imaging technique, imaging technique, affinity chromatography technology, two hybrid	Migliaccio A (2000), Teo AK (2001), Slentz-Kesler K (2000), Bourdoncle A (2005), Jaber BM (2004), Jaber BM (2004), Ku TK (2007), Cabodi S (2004), Monroe DG (2003), Hitosugi T (2007), Zwart W (2007), Zwart W (2007), Zwart W (2007), Yoshimaru T (2013), Yoshimaru T (2013), Zhang H (2006), Zhang H (2006), Zhang H (2006), Endler A (2012), Endler A (2012)	20
PPARGC1B	2	ESR1	0	two hybrid, pull down	Kressler D (2002), Kressler D (2007)	2
PPARG	0	PPARGC1B	2	affinity chromatography technology, affinity chromatography technology	Parham KA (2015), Parham KA (2015)	2
PPARGC1B	2	SRC	2	pull down	Kressler D (2007)	1
HNRNPL	3	PPARGC1B	2	affinity chromatography technology	Fei T (2017)	1
DNAJC10	3	PPARGC1B	2	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	THRB	1	pull down	Miyazaki W (2004)	1
PPARG	0	PIAS1	4	affinity chromatography technology, imaging technique	Pascual G (2005), Pascual G (2005)	2
NR1H2	2	PPARGC1B	2	affinity chromatography technology	Zhang Y (2012)	1