PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
COL7A1	19	LAMA5	20	pull down, affinity chromatography technology	Rousselle P (1997), Rousselle P (1997)	2
COL7A1	19	LRRC57	0	biochemical	Havugimana PC (2012)	1
MOV10	6	COL7A1	19	affinity chromatography technology	Castello A (2012)	1
COL7A1	19	LAMB3	5	pull down	Chen M (1999)	1
FN1	17	COL7A1	19	pull down, pull down	Lapiere JC (1994), Chen M (1997)	2
COL7A1	19	COL4A1	9	pull down	Chen M (1997)	1
THBS1	6	COL4A1	9	pull down	Galvin NJ (1987)	1
NFKBIA	0	COL7A1	19	affinity chromatography technology	Hein MY (2015)	1
COL7A1	19	COL1A1	1	pull down	Chen M (1997)	1
COL7A1	19	LAMC2	2	pull down	Chen M (1999)	1
NXF1	0	COL7A1	19	affinity chromatography technology	Castello A (2012)	1
THBS1	6	COL7A1	19	two hybrid	Aho S (1998)	1
SNCA	0	COL7A1	19	affinity chromatography technology	Hein MY (2015)	1
THBS1	6	COL1A1	1	pull down	Galvin NJ (1987)	1