Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
COL1A1	1277	HALOFUGINONE	CHEMBL1197091		DrugBank	11099465
COL1A1	1277	OCRIPLASMIN	CHEMBL2095222		ChemblInteractions
COL1A1	1277	COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	CHEMBL2108709		TdgClinicalTrial, ChemblInteractions, TEND, DrugBank	15659034, 17440987, 12101112, 12535212, 12855673
COL1A1	1277	ZOLEDRONIC ACID	CHEMBL924		PharmGKB
COL1A1	1277	SOMATROPIN	CHEMBL1201621		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
COL1A1	rs1800012	AA + AC	etidronic acid	efficacy	yes	in term of increase of femoral neck bone mineral density (BMD)	Genotypes AA + AC are associated with decreased response to etidronic acid in people with Bone Diseases, Metabolic as compared to genotype CC.	11907712	769171370
COL1A1	rs1800012	AA	somatropin recombinant	dosage	yes	In those who also were also carriers of the GHR d3 (deletion absence of exon 3) variant compared to homozygotes of the full length GHR gene (genotype fl/fl) and rs1800012 genotype CC. Carriers of the GHR d3 allele and genotype rs180012 AA had around 50% increased responsiveness to the drug, thus required a lower dose.	Genotype AA is associated with decreased dose of somatropin recombinant in people with growth hormone deficiency as compared to genotype CC.	22026923	827819994