Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ADH1C 126 CHEMBL1161866 CHEMBL1161866 DrugBank 12604203, 17139284, 17016423
ADH1C 126 CHEMBL48122 CHEMBL48122 DrugBank 17139284, 17016423
ADH1C 126 2-ETHOXYETHANOL CHEMBL119596 DrugBank 17139284, 17016423, 10592235
ADH1C 126 PYRAZOLE CHEMBL15967 DrugBank 17139284, 17016423, 10592235
ADH1C 126 TRIFLUOROETHANOL CHEMBL116675 DrugBank 17139284, 17016423, 10592235
ADH1C 126 CHEMBL1235132 CHEMBL1235132 DrugBank 17139284, 17016423, 10592235
ADH1C 126 CHEMBL1232182 CHEMBL1232182 DrugBank 17139284, 17016423, 10592235
ADH1C 126 FOMEPIZOLE CHEMBL1308 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11391066, 16946442, 16871118, 19458366
ADH1C 126 CHOLIC ACID CHEMBL205596 DrugBank 10592235
ADH1C 126 CHEMBL184410 CHEMBL184410 DrugBank 17139284, 17016423, 10592235
ADH1C 126 CHEMBL335060 CHEMBL335060 DrugBank 10592235
ADH1C 126 CYCLOHEXYLFORMAMIDE CHEMBL46778 DrugBank 17139284, 17016423, 10592235
ADH1C 126 CHEMBL1232817 CHEMBL1232817 DrugBank 17139284, 17016423, 10592235
ADH1C 126 TRETINOIN CHEMBL38 NCI 11959987
ADH1C 126 ALCOHOL CHEMBL545 PharmGKB

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ADH1C rs1662060 C ethanol "toxicity","metabolism/PK" yes The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand. Allele C is associated with metabolism of ethanol. 19193628 827566681
ADH1C rs283411 A ethanol "toxicity","metabolism/PK" yes The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand. Allele A is associated with metabolism of ethanol. 19193628 827566688
ADH1C rs283416 A ethanol "toxicity","metabolism/PK" yes The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand. Allele A is associated with metabolism of ethanol. 19193628 827566695