PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DNM1L	3	MIEF2	4	pull down	Koirala S (2013)	1
AGTRAP	1	MIEF2	4	two hybrid	Rolland T (2014)	1
PSMF1	0	MIEF2	4	two hybrid	Rual JF (2005)	1
RABAC1	0	MIEF2	4	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
UBQLN4	2	MIEF2	4	two hybrid	Lim J (2006)	1
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
UBQLN1	1	MIEF2	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2