Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
ADH1B	125	FOMEPIZOLE	CHEMBL1308	inhibitor	TdgClinicalTrial, ChemblInteractions, TEND, DrugBank	19458366, 16946442, 16871118, 1590750, 11391066, 2573502
ADH1B	125	GLYCERIN	CHEMBL692		DrugBank	17139284, 17016423, 10592235
ADH1B	125	CHEMBL1161862	CHEMBL1161862		DrugBank	17139284, 17016423, 10592235
ADH1B	125	CYCLOHEXANOL	CHEMBL32010		DrugBank	17139284, 17016423
ADH1B	125	ALCOHOL	CHEMBL545		PharmGKB
ADH1B	125	CHEMBL46293	CHEMBL46293		DrugBank	17139284, 17016423
ADH1B	125	HEPTYLFORMAMIDE	CHEMBL43719		DrugBank	17139284, 17016423
ADH1B	125	CHEMBL1161866	CHEMBL1161866		DrugBank	16897483

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ADH1B	rs1229985	G	ethanol	"toxicity","metabolism/PK"	yes	The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand.	Allele G is associated with metabolism of ethanol.	19193628	827566667
ADH1B	rs2018417	A	ethanol	"toxicity","metabolism/PK"	yes	The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand.	Allele A is associated with metabolism of ethanol.	19193628	827566674
ADH1B	rs1229984	CT	acetaldehyde	metabolism/PK	yes	Blood concentrations of acetaldehyde, a metabolite of ethanol were significantly higher in individuals with the CT genotype compared to CC and TT at 30 minutes and 180 minutes following dosing with alcohol.	Genotype CT is associated with increased concentrations of acetaldehyde in healthy individuals as compared to genotypes CC + TT.	31002879	1450936730
ADH1B	rs1229984	CC + CT	ethanol	metabolism/PK	no	No significant difference in blood alcohol concentrations (BAC) over time between different genotypes.	Genotypes CC + CT are not associated with concentrations of ethanol in healthy individuals as compared to genotype TT.	31002879	1450936696
ADH1B	rs17033	C	ethanol	"toxicity","metabolism/PK"	yes	The authors did not report p-value correction for multiple hypotheses (103 snps tested). Though they report multiple snps are significantly associated with alcohol metabolism (early or late) tested on blood or breath alcohol concentrations, this snp is NOT significant after Bonferroni correction (<0.00049). Also, the authors did not state which alleles are associated with increased or decreased metabolism. Instead, they simply report an association with the snp in general. Note that this gene is on the minus strand.	Allele C is associated with metabolism of ethanol.	19193628	827566660