PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
WDR81	5	MAP1LC3C	0	affinity chromatography technology, affinity chromatography technology, pull down	Liu X (2017), Liu X (2017), Liu X (2017)	3
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	WDR91	2	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	WDR91	2	affinity chromatography technology	Emdal KB (2015)	1
BLNK	2	WDR81	5	affinity chromatography technology	Oellerich T (2011)	1
XPO1	8	WDR81	5	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	SHMT2	3	affinity chromatography technology	Emdal KB (2015)	1
WDR81	5	WDR91	2	imaging technique	Liu X (2017)	1
MOV10	6	WDR81	5	affinity chromatography technology	Castello A (2012)	1
MAP1LC3C	0	UBC	7	imaging technique	Liu X (2017)	1
BECN1	2	WDR81	5	affinity chromatography technology	Liu X (2017)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
CUL3	17	MOV10	6	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
BECN1	2	UBC	7	pull down	Shi CS (2010)	1
CUL3	17	PPP4C	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	WDR81	5	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
NXF1	0	SQSTM1	0	affinity chromatography technology	Castello A (2012)	1
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
ENO1	3	WDR81	5	affinity chromatography technology	Castello A (2012)	1
MAPK15	1	WDR81	5	affinity chromatography technology	Varjosalo M (2013)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
XPO1	8	PPP4C	0	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	ENO1	3	affinity chromatography technology	Emdal KB (2015)	1
TMEM237	1	WDR81	5	bioid	Gupta GD (2015)	1
SQSTM1	0	MAP1LC3C	0	affinity chromatography technology	Kirkin V (2009)	1
CUL3	17	ENO1	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	SHMT2	3	affinity chromatography technology	Bennett EJ (2010)	1
NXF1	0	WDR81	5	affinity chromatography technology	Castello A (2012)	1
CUL3	17	NXF1	0	affinity chromatography technology	Bennett EJ (2010)	1
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
MAP1LC3C	0	CUL3	17	pull down	Genau HM (2015)	1
SHMT2	3	WDR81	5	affinity chromatography technology	Castello A (2012)	1
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
BECN1	2	WDR91	2	affinity chromatography technology	Liu X (2017)	1
WDR81	5	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Liu X (2017), Liu X (2017), Liu X (2017), Liu X (2017)	4
NTRK1	1	WDR81	5	affinity chromatography technology	Emdal KB (2015)	1
CUL3	17	WDR91	2	affinity chromatography technology	Wimuttisuk W (2014)	1
WFDC2	2	WDR81	5	affinity chromatography technology	Huttlin EL (2017)	1
PPP4C	0	WDR81	5	affinity chromatography technology	Glatter T (2009)	1
MOV10	6	SQSTM1	0	affinity chromatography technology	Castello A (2012)	1
WFDC2	2	WDR91	2	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	BECN1	2	affinity chromatography technology	Kirli K (2015)	1
NTRK1	1	MOV10	6	affinity chromatography technology	Emdal KB (2015)	1
WDR81	5	UBC	7	imaging technique	Liu X (2017)	1