PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDK9	3	LARP7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Markert A (2008), Markert A (2008), Markert A (2008), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	10
TERF1	1	CCNT1	3	affinity chromatography technology	Giannone RJ (2010)	1
FERD3L	0	HEXIM2	0	affinity chromatography technology	Huttlin EL (2017)	1
MEPCE	1	LARP7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Markert A (2008), Li S (2014)	3
TERF2	2	USP9X	15	affinity chromatography technology	Giannone RJ (2010)	1
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
HEXIM2	0	CSNK2A1	15	affinity chromatography technology	Huttlin EL (2017)	1
HEXIM2	0	CSNK2B	5	affinity chromatography technology	Huttlin EL (2017)	1
RNPS1	1	HEXIM2	0	two hybrid	Rolland T (2014)	1
CDK9	3	CSNK2B	5	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Claudio PP (2006)	2
HNRNPL	3	HEXIM2	0	affinity chromatography technology	Fei T (2017)	1
CCNT1	3	CDK9	3	pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, genetic interference, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, biochemical, affinity chromatography technology, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cabart P (2004), Young TM (2003), Michels AA (2003), Michels AA (2003), Michels AA (2003), Hoque M (2003), Kiernan RE (2001), De Falco G (2000), Fu TJ (1999), Fu TJ (1999), Peng J (1998), Peng J (1998), Peng J (1998), Garber ME (2000), Garber ME (2000), Garber ME (2000), He N (2006), Jeronimo C (2007), Bres V (2009), Gargano B (2007), Yokoyama A (2010), Fryer CJ (2004), Yik JH (2003), Mak AB (2010), Mak AB (2010), Liu M (2012), Shan B (2005), Baumli S (2008), Baumli S (2008), Havugimana PC (2012), Herrmann CH (2001), Herrmann CH (2001), Herrmann CH (2001), Napolitano G (2003), Chen R (2004), Chen R (2004), Chen R (2004), Larochelle S (2012), Yik JH (2005), Napolitano G (1999), Garriga J (1998), Napolitano G (2002), Nguyen VT (2001), Takahashi H (2011), Yang Z (2005), Yang Z (2001), Yang Z (2001), Pinhero R (2004), Byers SA (2005), Wei P (1998), Wei P (1998), Wei P (1998), Wei P (1998), Markert A (2008), Markert A (2008), Markert A (2008), Markert A (2008), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Lin PH (2011), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	64
HEXIM2	0	SURF2	0	affinity chromatography technology	Huttlin EL (2017)	1
TERF2	2	HEXIM2	0	two hybrid	Lee OH (2011)	1
TCF4	26	FERD3L	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
XPO1	8	RNPS1	1	affinity chromatography technology	Kirli K (2015)	1
MEOX2	2	AHCYL1	2	two hybrid	Rolland T (2014)	1
RN7SK	0	CCNT1	3	two hybrid	Michels AA (2004)	1
LARP7	3	RN7SK	0	affinity chromatography technology, unspecified method	Markert A (2008), Markert A (2008)	2
XPO1	8	CSNK2B	5	affinity chromatography technology	Kirli K (2015)	1
HEXIM2	0	RN7SK	0	affinity chromatography technology	Yik JH (2005)	1
TERF2	2	CSNK2A2	1	affinity chromatography technology	Giannone RJ (2010)	1
RNPS1	1	CSNK2B	5	affinity chromatography technology	Ewing RM (2007)	1
MEPCE	1	CSNK2A2	1	affinity chromatography technology	Jeronimo C (2007)	1
RNPS1	1	RIOX2	1	affinity chromatography technology	Hein MY (2015)	1
TCF4	26	TCF12	14	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
PIM1	2	BANP	1	two hybrid	Rolland T (2014)	1
HEXIM2	0	USP9X	15	affinity chromatography technology	Huttlin EL (2017)	1
PRDM14	1	HEXIM2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
HEXIM2	0	HAL	1	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	AHCYL2	4	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	BANP	1	affinity chromatography technology	Fei T (2017)	1
TERF2	2	HEXIM1	1	two hybrid	Lee OH (2011)	1
HEXIM2	0	CSNK2A2	1	affinity chromatography technology	Huttlin EL (2017)	1
MEPCE	1	RN7SK	0	enzymatic study	Jeronimo C (2007)	1
HEXIM1	1	CSNK2A2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HEXIM1	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HEXIM2	0	HEXIM2	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
HEXIM2	0	LARP7	3	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
HEXIM2	0	MYCBP	0	affinity chromatography technology	Huttlin EL (2017)	1
HEXIM2	0	ZNF250	2	two hybrid	Yu H (2011)	1
TERF2	2	CCNT1	3	affinity chromatography technology	Giannone RJ (2010)	1
XPO1	8	AHCYL2	4	affinity chromatography technology	Kirli K (2015)	1
MEOX2	2	HEXIM2	0	two hybrid	Rolland T (2014)	1
MEPCE	1	CCNT1	3	affinity chromatography technology	Jeronimo C (2007)	1
PIN1	0	CSNK2A2	1	pull down, affinity chromatography technology	Messenger MM (2002), Messenger MM (2002)	2
HEXIM2	0	HEXIM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yik JH (2005), Huttlin EL (2015), Huttlin EL (2017)	3
RNPS1	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Hein MY (2015)	2
RNPS1	1	CSNK2A2	1	affinity chromatography technology	Ewing RM (2007)	1
SPRY1	2	HEXIM2	0	two hybrid	Rolland T (2014)	1
TADA3	0	HEXIM2	0	two hybrid	Rolland T (2014)	1
SURF2	0	HEXIM1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TERF2	2	CCNT2	4	affinity chromatography technology	Giannone RJ (2010)	1
LARP7	3	CCNT1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Markert A (2008), Markert A (2008), Lu H (2014)	3
TERF1	1	LARP7	3	affinity chromatography technology	Giannone RJ (2010)	1
HEXIM2	0	CCNT2	4	affinity chromatography technology	Huttlin EL (2017)	1
HEXIM1	1	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Michels AA (2003), He N (2006), Jeronimo C (2007), Yik JH (2003), Yik JH (2003), Yik JH (2003), Liu M (2012), Lew QJ (2012), Yik JH (2005), Yik JH (2005), Yang Z (2005), Yang Z (2005), Byers SA (2005), Yik JH (2004), Michels AA (2004), Michels AA (2004), Markert A (2008), Markert A (2008), Markert A (2008), Markert A (2008), Markert A (2008), Varjosalo M (2013), Lu H (2014), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	26
CSNK2A1	15	LARP7	3	enzymatic study	Zhang M (2011)	1
HEXIM1	1	RN7SK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Michels AA (2003), Yik JH (2003), Yik JH (2005), Yang Z (2005), Yik JH (2004), Michels AA (2004), Michels AA (2004), Markert A (2008)	8
TERF1	1	HEXIM2	0	two hybrid	Lee OH (2011)	1
AHCYL2	4	AHCYL1	2	affinity chromatography technology	Huttlin EL (2017)	1
HEXIM2	0	BANP	1	affinity chromatography technology	Huttlin EL (2017)	1
HEXIM1	1	CCNT2	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Michels AA (2003), Huttlin EL (2015), Huttlin EL (2017)	3
TERF1	1	USP9X	15	affinity chromatography technology	Giannone RJ (2010)	1
MEPCE	1	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	7
CSNK2A1	15	HNRNPL	3	enzymatic study	Zhang M (2011)	1
CDK9	3	RN7SK	0	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yik JH (2003), Yik JH (2003), Yik JH (2005), Nguyen VT (2001), Yang Z (2005), Yang Z (2001), Markert A (2008)	7
HEXIM2	0	RIOX2	1	affinity chromatography technology	Huttlin EL (2017)	1
TCF4	26	HEXIM2	0	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
PIN1	0	HEXIM2	0	two hybrid	Rolland T (2014)	1
TERF1	1	HEXIM1	1	two hybrid	Lee OH (2011)	1
CDK9	3	CCNT2	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Peng J (1998), Peng J (1998), Peng J (1998), Jeronimo C (2007), Baumli S (2008), Cottone G (2006), Napolitano G (1999), Nguyen VT (2001), Takahashi H (2011), Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	14
TERF1	1	CDK9	3	affinity chromatography technology	Giannone RJ (2010)	1
CSNK2B	5	CSNK2A2	1	two hybrid, affinity chromatography technology, far western blotting, two hybrid, enzymatic study, biochemical, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lehner B (2004), Kim MS (1998), Marin O (1997), Bosc DG (2000), Watabe M (2011), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Goetz C (1999), Hauri S (2016)	13
SURF2	0	RIOX2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HEXIM2	0	AHCYL2	4	affinity chromatography technology	Huttlin EL (2017)	1
TERF2	2	CSNK2B	5	affinity chromatography technology	Giannone RJ (2010)	1
PIN1	0	RNPS1	1	pull down	Ingham RJ (2005)	1
MEOX2	2	SPRY1	2	two hybrid	Rolland T (2014)	1
TERF1	1	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
CDK9	3	CSNK2A1	15	affinity chromatography technology	Claudio PP (2006)	1
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
MEPCE	1	HEXIM2	0	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2017)	2
FERD3L	0	TCF12	14	affinity chromatography technology	Huttlin EL (2017)	1
AHCYL1	2	USP9X	15	biochemical	Havugimana PC (2012)	1
XPO1	8	USP9X	15	affinity chromatography technology	Kirli K (2015)	1
PIM1	2	PIN1	0	affinity chromatography technology	Ma J (2007)	1
HEXIM2	0	AHCYL1	2	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	AHCYL1	2	affinity chromatography technology	Kirli K (2015)	1
TERF1	1	CSNK2A2	1	affinity chromatography technology	Giannone RJ (2010)	1
TERF2	2	BANP	1	two hybrid	Lee OH (2011)	1
MEOX2	2	SPRY2	4	two hybrid	Rolland T (2014)	1
TERF2	2	LARP7	3	affinity chromatography technology	Giannone RJ (2010)	1
XPO1	8	TCF12	14	affinity chromatography technology	Kirli K (2015)	1
GATA1	1	HEXIM2	0	two hybrid	Rolland T (2014)	1
MEPCE	1	HEXIM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Huttlin EL (2015), Huttlin EL (2017)	3
MEPCE	1	CSNK2B	5	affinity chromatography technology	Jeronimo C (2007)	1
LARP7	3	HEXIM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Markert A (2008), Markert A (2008), Markert A (2008), Markert A (2008), Lu H (2014), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	8
HEXIM1	1	CSNK2B	5	affinity chromatography technology	Huttlin EL (2015)	1
PIN1	0	CSNK2A1	15	pull down, affinity chromatography technology	Messenger MM (2002), Messenger MM (2002)	2
SPRY2	4	SPRY1	2	affinity chromatography technology, two hybrid	Mason JM (2004), Rolland T (2014)	2
XPO1	8	CSNK2A2	1	affinity chromatography technology	Kirli K (2015)	1
AHCYL2	4	BANP	1	affinity chromatography technology	Huttlin EL (2017)	1
PIM1	2	HEXIM2	0	two hybrid	Rolland T (2014)	1
HEXIM1	1	CCNT1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Michels AA (2003), Michels AA (2003), Yik JH (2003), Wittmann BM (2005), Wittmann BM (2005), Yang Z (2005), Yik JH (2004), Michels AA (2004), Michels AA (2004), Michels AA (2004), Michels AA (2004), Markert A (2008), Markert A (2008), Markert A (2008), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017), Schulte A (2005), Schulte A (2005), Schulte A (2005)	20
XPO1	8	CSNK2A1	15	affinity chromatography technology	Kirli K (2015)	1
MEOX2	2	PIN1	0	two hybrid	Rolland T (2014)	1
HEXIM2	0	CCDC36	1	two hybrid	Rolland T (2014)	1
SPRY2	4	HEXIM2	0	two hybrid	Rolland T (2014)	1
HEXIM2	0	CCNT1	3	affinity chromatography technology	Huttlin EL (2017)	1
TCF12	14	HEXIM2	0	two hybrid, two hybrid, affinity chromatography technology	Rolland T (2014), Yu H (2011), Huttlin EL (2017)	3
PIN1	0	TCF4	26	two hybrid	Rolland T (2014)	1
CDK9	3	HEXIM2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Yik JH (2005), Yik JH (2005), Byers SA (2005), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	7
TERF2	2	CDK9	3	affinity chromatography technology	Giannone RJ (2010)	1
MEPCE	1	CCNT2	4	affinity chromatography technology	Jeronimo C (2007)	1
MEPCE	1	XPO1	8	affinity chromatography technology	Jeronimo C (2007)	1
TERF1	1	CSNK2B	5	affinity chromatography technology	Giannone RJ (2010)	1
XPO1	8	HEXIM2	0	affinity chromatography technology	Kirli K (2015)	1