Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SLC24A4 rs77441273 AG salbutamol efficacy yes The allele associated with increased response and low frequency is not explicitly stated. Response is increased for carriers of the rare, minor allele. This association was significant in the initial GWAS (in GALA II). In an attempted replication by imputation in silico in GALA I, there was a consistent direction of effect in Puerto Ricans, but the result was not significant. GALAII genotyping was done using the Affymetrix LAT1 Array, which was designed to capture Latino population variation. Genotype AG is associated with increased response to salbutamol in children with Asthma as compared to genotype GG. 23992748 1183680047