PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
FRS3	0	SOCS4	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
SOCS4	0	PINK1	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
SPRY1	2	GRB2	2	affinity chromatography technology	Lao DH (2006)	1
SOCS4	0	MPP5	2	two hybrid	Grossmann A (2015)	1
SOCS4	0	ELOC	0	affinity chromatography technology	Linossi EM (2013)	1
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
NR4A1	4	SOCS4	0	two hybrid	Wang J (2011)	1
SOCS4	0	TNK2	7	two hybrid	Grossmann A (2015)	1
EGFR	5	PIK3R3	0	unspecified method, two hybrid, imaging technique, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014)	4
EGFR	5	TNK2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Lin Q (2010), Pao-Chun L (2009), Shen F (2007), Howlin J (2008), Howlin J (2008), Tong J (2008), Jones S (2014), Jones S (2014), Chua BT (2010)	9
GRB2	2	SOCS4	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
PIK3R3	0	RBP7	3	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
MDFIC	1	SOCS4	0	two hybrid	Wang J (2011)	1
FRS3	0	PIK3R3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
SOCS4	0	PLPP6	2	two hybrid	Grossmann A (2015)	1
SOCS4	0	RBP7	3	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
TNK2	7	GRB2	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Satoh T (1996), Kato-Stankiewicz J (2001), Bandyopadhyay S (2010), Lin Q (2010), Lin Q (2012), Yeow-Fong L (2005), Chan W (2011), Yokoyama N (2003), Huttlin EL (2017), Mahendrarajah N (2017)	10
CUL5	1	SOCS4	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
SOCS4	0	SPRY1	2	two hybrid	Wang J (2011)	1
SOCS4	0	LDHAL6B	0	two hybrid	Grossmann A (2015)	1
SOCS4	0	VWF	11	two hybrid	Wang J (2011)	1
PIK3R3	0	SOCS4	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
SOCS4	0	EGFR	5	unspecified method	Bullock AN (2007)	1
SOCS4	0	CNMD	2	two hybrid	Grossmann A (2015)	1
GRB2	2	PIK3R3	0	affinity chromatography technology	Bisson N (2011)	1
SOCS4	0	ELOB	1	affinity chromatography technology	Linossi EM (2013)	1