PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AEBP2	1	LACRT	1	affinity chromatography technology	Hauri S (2016)	1
AEBP2	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
KMT5A	2	EED	1	biochemical	Cao R (2002)	1
HMBOX1	2	AEBP2	1	two hybrid	Rolland T (2014)	1
RBBP7	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
AEBP2	1	LGALS7B	0	affinity chromatography technology	Hauri S (2016)	1
RBBP7	1	RPL39	0	affinity chromatography technology	Hauri S (2016)	1
HIST1H1A	0	AEBP2	1	pull down	Martin C (2006)	1
HIST1H1C	2	EED	1	pull down, affinity chromatography technology	Martin C (2006), Cao Q (2014)	2
ELAVL1	0	JARID2	7	affinity chromatography technology	Abdelmohsen K (2009)	1
HIST1H1A	0	SUZ12	0	pull down	Martin C (2006)	1
JARID2	7	EZH1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Pasini D (2010), Hauri S (2016), Hauri S (2016)	4
THAP1	1	RALYL	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
JARID2	7	AEBP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
ELAVL1	0	KMT5A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
AEBP2	1	THAP1	1	two hybrid	Yu H (2011)	1
BTRC	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2014), Sahasrabuddhe AA (2014), Huttlin EL (2017)	3
EZH2	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
AEBP2	1	RPL39	0	affinity chromatography technology	Hauri S (2016)	1
ELAVL1	0	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Abdelmohsen K (2009), Cao Q (2014)	2
HMBOX1	2	APP	1	pull down	Olah J (2011)	1
AEBP2	1	S100A7	1	affinity chromatography technology	Hauri S (2016)	1
APP	1	THAP1	1	pull down	Virok DP (2011)	1
KMT5A	2	EZH2	4	biochemical	Cao R (2002)	1
AEBP2	1	RALYL	1	two hybrid	Rual JF (2005)	1
EZH2	4	JARID2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Li G (2010), Li G (2010), Li G (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	11
BTRC	1	AEBP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loveless TB (2015), Loveless TB (2015), Huttlin EL (2017)	3
AEBP2	1	PIP	4	affinity chromatography technology	Hauri S (2016)	1
EED	1	AEBP2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
EZH1	1	RBBP7	1	affinity chromatography technology	Hauri S (2016)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
LACRT	1	APP	1	pull down	Olah J (2011)	1
EED	1	RBBP4	3	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
FBXW11	2	ELAVL1	0	affinity chromatography technology	Low TY (2014)	1
KMT5A	2	SUZ12	0	biochemical	Cao R (2002)	1
AEBP2	1	PIGR	4	affinity chromatography technology	Hauri S (2016)	1
ELAVL1	0	AEBP2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
FBXW11	2	EED	1	affinity chromatography technology	Huttlin EL (2017)	1
KMT5A	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang Z (2015), Wang Z (2015), Wang Z (2015), Wang Z (2015), Wang Z (2015)	5
HIST1H1A	0	EED	1	pull down	Martin C (2006)	1
HIST1H1C	2	AEBP2	1	pull down	Martin C (2006)	1
AEBP2	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
EED	1	SUZ12	0	biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2004), Cao R (2004), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Sarma K (2008), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Chan YS (2013), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	22
EZH2	4	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su IH (2005), Aoto T (2008), Hansen KH (2008), Li G (2010), Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2008), Pasini D (2008), Sarma K (2008), Xu B (2011), Xu B (2011), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Lee ST (2011), Havugimana PC (2012), Sahasrabuddhe AA (2014), Wang L (2013), Wu L (2013), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Bhatnagar S (2014), Bhatnagar S (2014), Zhao R (2015), Wienken M (2016), Huttlin EL (2017), Zhang H (2016), Zhang H (2016), Mahara S (2016), Hauri S (2016), Hauri S (2016)	40
FBXW11	2	AEBP2	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014)	2
EZH2	4	AEBP2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
HIST1H1C	2	SUZ12	0	pull down, affinity chromatography technology	Martin C (2006), Cao Q (2014)	2
BTRC	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2014), Huttlin EL (2017)	2
AEBP2	1	SCGB2A1	0	affinity chromatography technology	Hauri S (2016)	1
EZH1	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008)	3
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
HIST1H1A	0	RBBP4	3	pull down	Martin C (2006)	1
LDOC1	0	AEBP2	1	two hybrid	Rual JF (2005)	1
EZH2	4	LGALS7	0	affinity chromatography technology	Cao Q (2014)	1
EZH1	1	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008), Jones CA (1998), van Lohuizen M (1998), Wang X (2017), Hauri S (2016), Hauri S (2016)	8
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
JARID2	7	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
EZH2	4	EED	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, pull down, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Lohuizen M (1998), van Lohuizen M (1998), van Lohuizen M (1998), van der Vlag J (1999), van der Vlag J (1999), van der Vlag J (1999), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Denisenko O (1998), Pasini D (2004), Cao R (2004), Su IH (2005), Hansen KH (2008), Margueron R (2008), Margueron R (2008), Shen X (2008), Shen X (2008), Hernandez-Munoz I (2005), Sarma K (2008), Sarma K (2008), Han Z (2007), Avdic V (2011), Kaneko S (2010), Kaneko S (2010), Yap DB (2011), Satijn DP (2001), Satijn DP (2001), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Sewalt RG (1998), Wang L (2013), Wu L (2013), Pasini D (2010), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Chan YS (2013), Zhang H (2016), Zhang H (2016), Wang X (2017), Hauri S (2016), Hauri S (2016)	49
AEBP2	1	EZH1	1	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
JARID2	7	RBBP7	1	affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Hauri S (2016)	2
AEBP2	1	LGALS7	0	affinity chromatography technology	Hauri S (2016)	1
KMT5A	2	RBBP4	3	biochemical	Cao R (2002)	1
AEBP2	1	ATXN3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
SUZ12	0	RBBP4	3	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Havugimana PC (2012), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
AEBP2	1	JMJD6	1	two hybrid	Weimann M (2013)	1
SUZ12	0	AEBP2	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Cao R (2004), Pasini D (2010), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
JARID2	7	EED	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Pasini D (2010), Hein MY (2015), Hauri S (2016), Hauri S (2016)	5
ATXN3	2	APP	1	pull down	Olah J (2011)	1
FBXW11	2	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014), Huttlin EL (2017)	3
KMT5A	2	AEBP2	1	biochemical	Cao R (2002)	1
LGALS7	0	LGALS7B	0	affinity chromatography technology	Huttlin EL (2017)	1
EED	1	S100A7	1	affinity chromatography technology	Hauri S (2016)	1
RBBP4	3	AEBP2	1	pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2004), Hauri S (2016), Hauri S (2016)	3
BTRC	1	EED	1	affinity chromatography technology	Huttlin EL (2017)	1
AEBP2	1	KBTBD7	3	affinity chromatography technology	Huttlin EL (2015)	1
JARID2	7	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Hauri S (2016)	2
SUZ12	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pasini D (2010), Cao Q (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
AEBP2	1	LTF	2	affinity chromatography technology	Hauri S (2016)	1
EZH1	1	RBBP4	3	affinity chromatography technology	Hauri S (2016)	1
SUZ12	0	LGALS7	0	affinity chromatography technology	Cao Q (2014)	1
HIST1H1A	0	EZH2	4	pull down	Martin C (2006)	1
EZH2	4	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
FBXW11	2	EZH2	4	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Low TY (2014)	2
EZH1	1	SUZ12	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margueron R (2008), Margueron R (2008), Shen X (2008), Pasini D (2010), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1