Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
TPH2	121278	TELOTRISTAT	CHEMBL2103855	antagonist, inhibitor	ChemblInteractions, DrugBank
TPH2	121278	MIRTAZAPINE	CHEMBL654		PharmGKB
TPH2	121278	VENLAFAXINE	CHEMBL637		PharmGKB
TPH2	121278	TELOTRISTAT ETHYL	CHEMBL2105695	inhibitor	ChemblInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TPH2	rs4570625	TT	fluoxetine	efficacy	yes	Please note the association was only significant using the GAF/CGAS scale as outcome measure. Effect of HTR1B rs130058 on clinical improvement was measured by differences in scores obtained in GAF/CGAS, CDI, OCI-CV, SCARED, CGI-S, and CGI-I scales after fluoxetine treatment. For the other scales the results were not significantly different between the genotypes.	Genotype TT is associated with increased response to fluoxetine in children with Mental Disorders as compared to genotypes GG + GT.	27660918	1448265433
TPH2	rs1487278	C	mirtazapine	efficacy	yes		Allele C is associated with increased response to mirtazapine and venlafaxine in people with Depression as compared to genotype TT.	18496129	699642174
TPH2	rs1843809	TT	methylphenidate	efficacy	no		Genotype TT is not associated with response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity as compared to genotypes GG + GT.	23131881	981478810
TPH2	rs10879346	C	antidepressants	efficacy	yes		Allele C is associated with increased response to antidepressants in people with Depressive Disorder, Major as compared to genotype TT.	18496129	699642186
TPH2	rs4570625	GT + TT	citalopram	efficacy	no	Response was defined as response (Clinical Global Impressions - Improvement </=2). Association was non-significant.	Genotypes GT + TT is associated with increased response to citalopram in children with Depressive Disorder as compared to genotype GG.	23510446	1184505152
TPH2	rs11178998	A	venlafaxine	efficacy	no	Response assessed as remission, defined as MADRS score =<10 at the end of treatment.	Allele A is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele G.	28068779	1448601898
TPH2	rs1386494	C	citalopram	efficacy	no	This SNP was also not found to be associated with Major Depressive Disorder.	Allele C is not associated with response to citalopram, fluoxetine or paroxetine in people with Depressive Disorder, Major as compared to allele T.	19590397	981750822
TPH2	rs4570625	G	venlafaxine	efficacy	no	Response assessed as remission, defined as MADRS score =<10 at the end of treatment.	Allele G is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele T.	28068779	1448601904
TPH2	rs11178997	A	venlafaxine	efficacy	no	Response assessed as remission, defined as MADRS score =<10 at the end of treatment.	Allele A is not associated with response to venlafaxine in people with Depressive Disorder, Major as compared to allele T.	28068779	1448601887
TPH2	rs4570625	T	methylphenidate	efficacy	no		Allele T is not associated with response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity as compared to allele G.	23131881	981478817