PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2J2	1	UBE2J2	1	enzymatic study	David Y (2010)	1
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
PRKN	1	FBXO7	1	affinity chromatography technology, pull down, pull down	Burchell VS (2013), Burchell VS (2013), Burchell VS (2013)	3
UBE2J2	1	RNF10	0	two hybrid	Markson G (2009)	1
PRKN	1	UBE2J2	1	affinity chromatography technology, pull down	Oh RS (2006), Kazlauskaite A (2014)	2
WWP2	7	UBE2J2	1	pull down	Sheng Y (2012)	1
EGFR	5	XIAP	0	affinity chromatography technology	Yao Z (2017)	1
HERC4	0	UBC	7	enzymatic study	Sheng Y (2012)	1
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
NEDD4L	3	UBE2J2	1	pull down	Sheng Y (2012)	1
UBE2J2	1	UBC	7	enzymatic study	Sheng Y (2012)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
UBE2J2	1	TRIM25	5	two hybrid, affinity chromatography technology	Markson G (2009), Choudhury NR (2017)	2
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	MGRN1	4	affinity chromatography technology	Fei T (2017)	1
UBC	7	NEDD4L	3	x-ray crystallography, enzymatic study, enzymatic study, enzymatic study	Kamadurai HB (2009), Sheng Y (2012), Maspero E (2013), Michel MA (2015)	4
UBE2J2	1	UBA1	1	enzymatic study	Huguenin-Dezot N (2016)	1
TRIM25	5	HERC4	0	affinity chromatography technology	Choudhury NR (2017)	1
HERC4	0	UBE2J2	1	pull down	Sheng Y (2012)	1
RNF185	1	UBC	7	affinity chromatography technology	Iioka H (2007)	1
RNF185	1	UBE2J2	1	affinity chromatography technology	El Khouri E (2013)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
FBXO7	1	UBE2J2	1	enzymatic study	Teixeira FR (2016)	1
HNRNPL	3	XIAP	0	affinity chromatography technology	Fei T (2017)	1
MGRN1	4	ITCH	1	affinity chromatography technology	Gunn TM (2012)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
HECW1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
HECW1	3	UBE2J2	1	pull down	Zhang W (2016)	1
UBE2J2	1	EGFR	5	affinity chromatography technology	Chen S (2017)	1
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
HNRNPL	3	WWP2	7	affinity chromatography technology	Fei T (2017)	1
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
ATP13A2	1	UBE2J2	1	two hybrid	Usenovic M (2012)	1
ITCH	1	UBE2J2	1	pull down	Sheng Y (2012)	1
WWP2	7	ITCH	1	affinity chromatography technology	Chaudhary N (2014)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
TMEM129	2	UBE2J2	1	affinity chromatography technology	van de Weijer ML (2014)	1
ITCH	1	UBA1	1	affinity chromatography technology	OConnor HF (2015)	1
HNRNPL	3	UBE2J2	1	affinity chromatography technology	Fei T (2017)	1
ITCH	1	HNRNPL	3	pull down, affinity chromatography technology	Ingham RJ (2005), Fei T (2017)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UBE2J2	1	XIAP	0	two hybrid	Markson G (2009)	1
HNRNPL	3	NEDD4L	3	affinity chromatography technology	Fei T (2017)	1
UBE2J2	1	MGRN1	4	two hybrid	Markson G (2009)	1