PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LGALS3	0	TRIM6	1	pull down	Chauhan S (2016)	1
TRIM6	1	MYC	2	affinity chromatography technology, two hybrid	Sato T (2012), Sato T (2012)	2
TRIM6	1	TRIM5	4	two hybrid, pull down	Zhang F (2006), Li X (2006)	2
TRIM6	1	IKBKE	2	affinity chromatography technology, affinity chromatography technology	Rajsbaum R (2014), Rajsbaum R (2014)	2
IMPDH1	2	TRIM6	1	affinity chromatography technology	Huttlin EL (2017)	1
LGALS3	0	TRIM23	3	pull down	Chauhan S (2016)	1
TRIM28	1	TRIM23	3	biochemical	Reymond A (2001)	1
LGALS8	4	TRIM6	1	pull down	Chauhan S (2016)	1
TRIM23	3	LGALS8	4	two hybrid, pull down	Rolland T (2014), Chauhan S (2016)	2
TRIM6	1	TRIM28	1	biochemical	Reymond A (2001)	1
LGALS3	0	TRIM5	4	pull down, affinity chromatography technology	Chauhan S (2016), Chauhan S (2016)	2
MYC	2	TRIM28	1	affinity chromatography technology	Koch HB (2007)	1
LGALS8	4	TRIM5	4	pull down	Chauhan S (2016)	1
TRIM6	1	TRIM6	1	two hybrid, pull down, affinity chromatography technology	Reymond A (2001), Li X (2007), Li X (2011)	3
TRIM6	1	TRIM23	3	biochemical	Reymond A (2001)	1