PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRB2	2	ARAP1	7	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2017)	2
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
UBASH3B	4	ARAP1	7	affinity chromatography technology	Brehme M (2009)	1
HNRNPL	3	ARAP1	7	affinity chromatography technology	Fei T (2017)	1
ARAP1	7	TES	1	two hybrid	Yoon HY (2011)	1
CAPZA2	1	ARAP1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VCAM1	2	GRB2	2	affinity chromatography technology	Humphries JD (2009)	1
SNW1	0	XRCC6	3	affinity chromatography technology	Lleres D (2010)	1
NTRK1	1	ARIH2	4	affinity chromatography technology	Emdal KB (2015)	1
FGFR3	7	HNRNPL	3	two hybrid	Stelzl U (2005)	1
TES	1	APP	1	affinity chromatography technology	Sala S (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
CAPZA2	1	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
SH3KBP1	1	INPP5D	2	affinity chromatography technology, two hybrid	Kowanetz K (2004), Conde C (2012)	2
ARAP1	7	XRCC6	3	two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005)	2
ARAP1	7	INPP5D	2	two hybrid	Yoon HY (2011)	1
HMGXB4	0	ARAP1	7	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
ARPC3	0	ARAP1	7	two hybrid	Stelzl U (2005)	1
SHC1	0	APP	1	pull down, affinity chromatography technology	Tarr PE (2002), Tarr PE (2002)	2
SNW1	0	WAPL	1	affinity chromatography technology	Lleres D (2010)	1
GRB2	2	SH3KBP1	1	pull down, pull down	Gout I (2000), Borinstein SC (2000)	2
ARAP1	7	TP53BP1	3	two hybrid	Yoon HY (2011)	1
ARAP1	7	PSD3	4	two hybrid	Yoon HY (2011)	1
ARAP1	7	KCTD12	0	two hybrid	Yoon HY (2011)	1
NTRK1	1	SHC1	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Borrello MG (1994), Nakamura T (2002), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	7
TRIM25	5	CAPZA2	1	affinity chromatography technology	Choudhury NR (2017)	1
VCAM1	2	ARAP1	7	affinity chromatography technology	Humphries JD (2009)	1
VCAM1	2	HNRNPL	3	affinity chromatography technology	Humphries JD (2009)	1
ARAP1	7	SH3KBP1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Yoon HY (2011), Yoon HY (2011), Yoon HY (2011), Yoon HY (2011), Havrylov S (2009), Huttlin EL (2017)	6
INPP5D	2	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
HNRNPL	3	NCK2	2	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	SNW1	0	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Skolnik EY (1993), Skolnik EY (1993), Puil L (1994), Satoh T (1996), Fixman ED (1996), Fixman ED (1996), Fixman ED (1996), Ishihara H (1997), Fournier E (1999), Ravichandran KS (1994), Lamprecht R (2002), Park RK (1999), Sakaguchi K (2001), Park RK (1999), Park RK (1999), Hallak H (2001), Yokote K (1994), Saci A (2002), Zhang S (1999), Lazar DF (1994), VanderKuur J (1995), Kanai M (1997), Spivak-Kroizman T (1994), Giordano V (1997), Drobot L (2005), Erdreich-Epstein A (1997), Takahashi Y (1999), Barber DL (1997), Ahn SC (2003), Odai H (1995), Panchamoorthy G (1996), Panchamoorthy G (1996), Brehme M (2009), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Zhang L (1999), Brizzi MF (1996), Brizzi MF (1996), Liu BA (2012), Bisson N (2011), Fukazawa T (1996), Bisson N (2011), Umehara H (2002), Oksvold MP (2001), Oksvold MP (2001), Li J (2013), Li J (2013), Ueno H (1995), Prigent SA (1996), Wills MK (2014), Rausch O (1997), Ho JM (2002), Ho JM (2002), Yu WM (2006), Klint P (1995)	57
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
FPR2	1	ARAP1	7	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	ARAP1	7	affinity chromatography technology	Choudhury NR (2017)	1
NTRK1	1	WAPL	1	affinity chromatography technology	Emdal KB (2015)	1
ARPC3	0	CAPZA2	1	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
SHC1	0	ARAP1	7	affinity chromatography technology	Brehme M (2009)	1
TES	1	ARPC3	0	affinity chromatography technology	Sala S (2017)	1
TRIM25	5	XRCC6	3	affinity chromatography technology	Choudhury NR (2017)	1
SNW1	0	ARAP1	7	affinity chromatography technology	Lleres D (2010)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
GRB2	2	TAB1	1	affinity chromatography technology	Bisson N (2011)	1
GRB2	2	INPP5D	2	unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kavanaugh WM (1996), Kavanaugh WM (1996), de Castro RO (2012), Ho JM (2002)	4
INPP5D	2	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Dunant NM (2000), Wisniewski D (1999), Leitges M (2002), Damen JE (1996), Damen JE (1996), March ME (2000), Hunter MG (2004), Ho JM (2002)	9
TAB1	1	ARAP1	7	two hybrid	Vinayagam A (2011)	1
VCAM1	2	ARPC3	0	affinity chromatography technology	Humphries JD (2009)	1
FGFR3	7	GRB2	2	affinity chromatography technology, biochemical	Kanai M (1997), Wan C (2015)	2
ARIH2	4	ARAP1	7	two hybrid	Stelzl U (2005)	1
ARAP1	7	APP	1	pull down	Olah J (2011)	1
TP53BP1	3	XRCC6	3	affinity chromatography technology	Woods NT (2012)	1
NTRK1	1	XRCC6	3	affinity chromatography technology	Emdal KB (2015)	1
SHC1	0	UBASH3B	4	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
NCK2	2	ARAP1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
FGFR3	7	ARAP1	7	two hybrid	Stelzl U (2005)	1
VCAM1	2	XRCC6	3	affinity chromatography technology	Humphries JD (2009)	1
NTRK1	1	ARAP1	7	affinity chromatography technology	Emdal KB (2015)	1
TRIM25	5	UBASH3B	4	affinity chromatography technology	Choudhury NR (2017)	1
UBASH3B	4	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), Li J (2013), Li J (2013)	3
ARAP1	7	WAPL	1	two hybrid	Yoon HY (2011)	1