PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NUMB	1	OLIG1	0	two hybrid	Grossmann A (2015)	1
SH2D1B	0	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
RASA1	3	OLIG1	0	two hybrid	Grossmann A (2015)	1
NCK1	0	SH2D1A	0	two hybrid	Grossmann A (2015)	1
ID2	0	ID4	1	affinity chromatography technology	Huttlin EL (2017)	1
STAT5A	4	OLIG1	0	two hybrid	Grossmann A (2015)	1
PIK3R3	0	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
GRB2	2	OLIG1	0	two hybrid	Grossmann A (2015)	1
GRB7	1	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
TCF3	7	ID4	1	affinity chromatography technology	Teachenor R (2012)	1
GRB2	2	SH2D4A	0	two hybrid	Bandyopadhyay S (2010)	1
RASA1	3	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, pull down, affinity chromatography technology	Holland SJ (1997), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011)	7
ID2	0	OLIG1	0	affinity chromatography technology, affinity chromatography technology	Samanta J (2004), Samanta J (2004)	2
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
OLIG1	0	PSMD14	3	two hybrid	Wang J (2011)	1
SH2D1A	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
SHD	3	OLIG1	0	two hybrid	Grossmann A (2015)	1
HSH2D	1	PIK3R3	0	two hybrid	Grossmann A (2015)	1
NCK1	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
DOK5	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
DOK4	3	OLIG1	0	two hybrid	Grossmann A (2015)	1
ELSPBP1	1	OLIG1	0	affinity chromatography technology	Samanta J (2004)	1
CHD7	22	OLIG1	0	affinity chromatography technology	Engelen E (2011)	1
HCK	5	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
HSH2D	1	OLIG1	0	two hybrid	Grossmann A (2015)	1
ID2	0	TCF3	7	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Langlands K (1997), Teachenor R (2012), Mathas S (2009), Langlands K (1997), Lee SB (2016), Huttlin EL (2017)	6
CACNA1A	21	OLIG1	0	two hybrid	Kahle JJ (2011)	1
SH2D4A	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
PTPN6	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
OLIG1	0	TCF3	7	affinity chromatography technology	Samanta J (2004)	1
GRB2	2	RASA1	3	affinity chromatography technology	Lamprecht R (2002)	1
MRPL12	0	OLIG1	0	two hybrid	Wang J (2011)	1
HCK	5	PIK3R3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
GRB2	2	PSMD14	3	affinity chromatography technology	Brehme M (2009)	1
ID4	1	OLIG1	0	affinity chromatography technology, affinity chromatography technology	Samanta J (2004), Samanta J (2004)	2
HCK	5	RASA1	3	affinity chromatography technology, pull down	Briggs SD (1995), Briggs SD (1995)	2
GRB2	2	PIK3R3	0	affinity chromatography technology	Bisson N (2011)	1
RASA1	3	YES1	1	affinity chromatography technology	Cichowski K (1992)	1
NCK1	0	PIK3R3	0	two hybrid	Grossmann A (2015)	1
YES1	1	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2