PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATF4	2	JUN	0	pull down, two hybrid, fluorescent resonance energy transfe, fluorescent resonance energy transfe, imaging technique	Hai T (1991), Bandyopadhyay S (2010), Reinke AW (2013), Reinke AW (2013), Chen TC (2014)	5
BATF2	0	C2orf88	0	two hybrid	Wang J (2011)	1
BATF2	0	HLA-C	1	two hybrid	Wang J (2011)	1
KAT2A	1	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Mao X (2009), Mao X (2009), Mao X (2009), Ivanov AA (2017)	4
CEBPE	0	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	JUNB	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPE	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down	Reinke AW (2013), Reinke AW (2013), Reddy KV (2003)	3
BATF2	0	RELA	1	two hybrid	Wang J (2011)	1
CEBPE	0	DDIT3	1	two hybrid, pull down	Chih DY (2004), Chih DY (2004)	2
JUNB	0	JUN	0	affinity chromatography technology	Huttlin EL (2017)	1
RELA	1	JUN	0	two hybrid, genetic interference	Yang X (1999), Yang X (1999)	2
DBP	1	BATF2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
EPAS1	6	BATF2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
EPAS1	6	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF2	0	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPE	0	CEBPG	1	two hybrid, pull down, fluorescent resonance energy transfe	Chih DY (2004), Chih DY (2004), Reinke AW (2013)	3
DBP	1	CEBPG	1	fluorescent resonance energy transfe	Reinke AW (2013)	1
CEBPG	1	ATF4	2	fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Rolland T (2014)	2
CEBPA	0	JUN	0	affinity chromatography technology	Zada AA (2006)	1
DBP	1	CEBPA	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	MAFF	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DBP	1	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), Wang J (2011)	3
DDIT3	1	CEBPA	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Marwarha G (2016), Marwarha G (2016), Marwarha G (2016)	3
BATF2	0	CEBPA	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPA	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
CEBPG	1	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
BATF2	0	KAT2A	1	two hybrid	Wang J (2011)	1
MAFF	0	BATF2	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
EPAS1	6	DBP	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
BATF2	0	ATF4	2	fluorescent resonance energy transfe	Reinke AW (2013)	1
BATF2	0	CEBPG	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
EPAS1	6	JUN	0	fluorescent resonance energy transfe	Reinke AW (2013)	1
DDIT3	1	JUN	0	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Ubeda M (1999), Ubeda M (1999), Reinke AW (2013)	3
BATF2	0	JUN	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Reinke AW (2013), Reinke AW (2013)	2
ATF4	2	DDIT3	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), DeGrado-Warren J (2008)	3
ATF4	2	JUNB	0	two hybrid	Wang J (2011)	1
BATF2	0	DEDD	0	two hybrid	Wang J (2011)	1
CEBPG	1	DDIT3	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Hattori T (2003), Rolland T (2014)	3
BATF2	0	JUNB	0	fluorescent resonance energy transfe, fluorescent resonance energy transfe, two hybrid	Reinke AW (2013), Reinke AW (2013), Wang J (2011)	3
ATF4	2	CEBPE	0	imaging technique, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Lopez AB (2007), Reinke AW (2013), Reinke AW (2013)	3
ATXN1	2	BATF2	0	two hybrid	Lim J (2006)	1
DAZAP2	1	BATF2	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
CEBPE	0	BATF2	0	fluorescent resonance energy transfe	Reinke AW (2013)	1