PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
CUL5	1	ELOC	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology	Kamura T (2001), Nishiya T (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Kershaw NJ (2014), Huttlin EL (2017)	18
CISH	1	CCNC	0	affinity chromatography technology	Piessevaux J (2008)	1
CISH	1	IL3RA	0	affinity chromatography technology	Yoshimura A (1995)	1
ELOC	0	GHR	1	unspecified method	Bulatov E (2015)	1
SMAD2	5	CISH	1	two hybrid	Colland F (2004)	1
RACK1	2	ELOB	1	pull down	Liu YV (2007)	1
CISH	1	ELOC	0	affinity chromatography technology	Lavens D (2007)	1
BCL2L11	4	ELOB	1	affinity chromatography technology	Ambrosini G (2009)	1
RACK1	2	IL2RB	1	pull down	Usacheva A (2003)	1
UBC	7	LCK	0	unspecified method, x-ray crystallography	Kang J (2008), Kang J (2008)	2
EPOR	3	ELOC	0	pull down	Heir P (2016)	1
RACK1	2	ELOC	0	affinity chromatography technology, pull down, affinity chromatography technology	Subauste MC (2009), Liu YV (2007), Liu YV (2007)	3
CUL5	1	ELOB	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Kamura T (2001), Nie L (2011), Wolfe LS (2010), Yu X (2003), Xiao Z (2006), Zhou X (2012), Luo K (2007), Yu Y (2004), Bennett EJ (2010), Salter JD (2012), Muniz JR (2013), Kelsall IR (2013), Han X (2014), Fribourgh JL (2014), Guo Y (2014), Guo Y (2014), Antonioli M (2014), Kershaw NJ (2014)	18
CISH	1	RACK1	2	affinity chromatography technology	Zhang W (2008)	1
BCL2L11	4	CISH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ambrosini G (2009), Zhang W (2008), Zhang W (2008)	3
CISH	1	ELOB	1	affinity chromatography technology	Lavens D (2007)	1
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
SMAD2	5	CUL5	1	two hybrid	Colland F (2004)	1
UBC	7	CISH	1	affinity chromatography technology, affinity chromatography technology	Jensik PJ (2015), Jensik PJ (2015)	2
ELOB	1	GHR	1	unspecified method	Bulatov E (2015)	1
CISH	1	AMBRA1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSF3R	2	CISH	1	pull down, affinity chromatography technology	Hunter MG (2004), Hunter MG (2004)	2
UBC	7	ELOC	0	pull down	Zhang X (2017)	1
GHR	1	CISH	1	affinity chromatography technology, pull down, unspecified method	Ram PA (1999), Ram PA (1999), Bulatov E (2015)	3
CUL5	1	GHR	1	unspecified method	Bulatov E (2015)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
CISH	1	EPOR	3	affinity chromatography technology, protein complementation assay, pull down, protein complementation assay	Yoshimura A (1995), Lavens D (2007), Lavens D (2007), Montoye T (2005)	4
EGFR	5	CISH	1	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
LCK	0	SMAD2	5	pull down	Richard KC (2006)	1
MYD88	1	CISH	1	protein complementation assay, affinity chromatography technology	Lavens D (2007), Lavens D (2007)	2
IL7R	2	CISH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugden S (2016), Sugden S (2016), Ghazawi FM (2016)	3
CISH	1	HSPA6	1	two hybrid	Wang J (2011)	1
UBC	7	CCNE1	1	affinity chromatography technology	Huang G (2014)	1
CUL5	1	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Zhang X (2017)	2
ERBB2	6	CUL5	1	affinity chromatography technology	Ehrlich ES (2009)	1
CUL2	3	ELOB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kamura T (2001), Menon S (2008), Megumi Y (2005), Kamura T (2002), Brower CS (2002), Bennett EJ (2010), Pause A (1997), Kamura T (2004), Kelsall IR (2013)	9
AMBRA1	7	UBC	7	affinity chromatography technology	Antonioli M (2014)	1
CUL2	3	CISH	1	affinity chromatography technology	Zhang W (2008)	1
MAP3K7CL	0	CISH	1	two hybrid	Wang J (2011)	1
EPOR	3	CUL2	3	affinity chromatography technology	Heir P (2016)	1
CUL2	3	ELOC	0	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kamura T (2001), Maine GN (2007), Megumi Y (2005), Mao X (2009), Lonergan KM (1998), Lonergan KM (1998), Bennett EJ (2010), Pause A (1997), Pause A (1999), Kamura T (2004), Kelsall IR (2013), Lee SB (2016)	12
BCL2L11	4	RACK1	2	affinity chromatography technology, pull down	Zhang W (2008), Zhang W (2008)	2
AMBRA1	7	ELOB	1	affinity chromatography technology, affinity chromatography technology	Antonioli M (2014), Antonioli M (2014)	2
RACK1	2	IL7R	2	unspecified method	Evsyukova I (2013)	1
RACK1	2	CUL2	3	affinity chromatography technology	Zhang W (2008)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
CISH	1	TBC1D10B	4	affinity chromatography technology	Huttlin EL (2015)	1
ERBB2	6	CISH	1	unspecified method	Jones RB (2006)	1
CISH	1	CCNE1	1	affinity chromatography technology	Piessevaux J (2008)	1
EPOR	3	ELOB	1	pull down	Heir P (2016)	1
IL2RB	1	CISH	1	affinity chromatography technology, affinity chromatography technology	Aman MJ (1999), Aman MJ (1999)	2
CISH	1	CUL5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavens D (2007), Piessevaux J (2008), Huttlin EL (2015), Huttlin EL (2017)	4
CUL2	3	BCL2L11	4	affinity chromatography technology, affinity chromatography technology	Ambrosini G (2009), Zhang W (2008)	2
CUL5	1	CUL2	3	affinity chromatography technology	Bennett EJ (2010)	1
RACK1	2	EPOR	3	pull down	Usacheva A (2003)	1
CISH	1	ETV5	0	two hybrid	Wang J (2011)	1
LCK	0	IL2RB	1	affinity chromatography technology	Reneer MC (2011)	1
LCK	0	CISH	1	affinity chromatography technology	Venkitachalam S (2011)	1