Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CHRNB4 1143 VARENICLINE CHEMBL1396 TdgClinicalTrial
CHRNB4 1143 PENTOLINIUM CHEMBL1271 antagonist DrugBank 7761270
CHRNB4 1143 LARAZOTIDE ACETATE CHEMBL2103815 partial agonist ChemblInteractions
CHRNB4 1143 TRIMETHAPHAN CAMSYLATE CHEMBL1245 antagonist ChemblInteractions
CHRNB4 1143 TC-6499 CHEMBL3545353 agonist ChemblInteractions
CHRNB4 1143 MECAMYLAMINE HYDROCHLORIDE CHEMBL1237082 ChemblInteractions
CHRNB4 1143 ASM-024 CHEMBL3707249 antagonist ChemblInteractions
CHRNB4 1143 PENTOLINIUM TARTRATE CHEMBL1318287 antagonist ChemblInteractions
CHRNB4 1143 LEVOMETHADYL ACETATE CHEMBL1514 DrugBank 11561100

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CHRNB4 rs1948 A nicotine other no No significant association between this allele and status as a smoker or non-smoker. Allele A is not associated with exposure to nicotine in men as compared to allele G. 29666375 1450930684
CHRNB4 rs10851907 A cotinine metabolism/PK yes The authors conducted a GWAS meta-analysis to identify genetic variants associated with cotinine in current daily smokers (Caucasian). The following study cohorts were analyzed: ALSPAC, CARDIA, FinnTwin, Framingham, GenMets, MESA, NESDA, NTR, TwinsUK, YFS. The SNP was associated with a ~34 ng/ml increase in plasma/serum cotinine and accounted for 1.75% variance in cotinine levels. Allele A is associated with increased concentrations of cotinine in people with Tobacco Use Disorder as compared to allele G. 26833182 1447814206
CHRNB4 rs7178270 G nicotine other no No significant association between this allele and status as a smoker or non-smoker. Allele G is not associated with exposure to nicotine in men as compared to allele C. 29666375 1450930679
CHRNB4 rs950776 C nicotine other no No significant association between this allele and status as a smoker or non-smoker. Allele C is not associated with exposure to nicotine in men as compared to allele T. 29666375 1450930689