Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CHRNA7 1139 BUTABARBITAL CHEMBL449 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 APROBARBITAL CHEMBL7863 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 BUTETHAL CHEMBL404422 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 HEXOBARBITAL CHEMBL7728 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 BARBITAL CHEMBL444 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 CHEMBL134713 CHEMBL134713 TdgClinicalTrial, DrugBank 17591554, 15213292, 17334244
CHRNA7 1139 CYTISINE CHEMBL497939 agonist DrugBank 11553677, 25517706
CHRNA7 1139 EPIBATIDINE CHEMBL6623 agonist GuideToPharmacologyInteractions
CHRNA7 1139 ATRACURIUM CHEMBL1360 antagonist GuideToPharmacologyInteractions
CHRNA7 1139 AVL-3288 CHEMBL429317 positive allosteric modulator ChemblInteractions
CHRNA7 1139 APN1125 CHEMBL3545013 partial agonist ChemblInteractions
CHRNA7 1139 ZIPRASIDONE CHEMBL708 binder TTD
CHRNA7 1139 JNJ-39393406 CHEMBL3545291 positive allosteric modulator ChemblInteractions
CHRNA7 1139 RG3487 CHEMBL3544952 partial agonist, antagonist TdgClinicalTrial, ChemblInteractions, TTD
CHRNA7 1139 THIOPENTAL CHEMBL441 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 HEPTABARBITAL CHEMBL468837 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 CHEMBL403858 CHEMBL403858 agonist GuideToPharmacologyInteractions
CHRNA7 1139 PNU-282987 CHEMBL177611 agonist, antagonist GuideToPharmacologyInteractions, TTD
CHRNA7 1139 LYSERGIDE CHEMBL263881 antagonist GuideToPharmacologyInteractions
CHRNA7 1139 NICOTINE CHEMBL3 TdgClinicalTrial, TEND
CHRNA7 1139 ASM-024 CHEMBL3707249 modulator ChemblInteractions
CHRNA7 1139 AQW051 CHEMBL3545232 partial agonist, agonist GuideToPharmacologyInteractions, ChemblInteractions
CHRNA7 1139 SSR180711 CHEMBL559478 partial agonist ChemblInteractions
CHRNA7 1139 ENCENICLINE CHEMBL2151572 partial agonist, agonist GuideToPharmacologyInteractions, ChemblInteractions
CHRNA7 1139 PENTOBARBITAL CHEMBL448 TdgClinicalTrial, TEND
CHRNA7 1139 TALBUTAL CHEMBL1200802 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 PRIMIDONE CHEMBL856 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 MEPHOBARBITAL CHEMBL45029 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 PHENOBARBITAL CHEMBL40 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 VARENICLINE CHEMBL1396 agonist TdgClinicalTrial, TEND, DrugBank 16766716
CHRNA7 1139 BRADANICLINE CHEMBL1258006 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank
CHRNA7 1139 PHA-543613 CHEMBL214268 agonist GuideToPharmacologyInteractions, ChemblInteractions
CHRNA7 1139 CHEMBL257591 CHEMBL257591 allosteric modulator GuideToPharmacologyInteractions
CHRNA7 1139 TC-6987 CHEMBL3545410 agonist TdgClinicalTrial, ChemblInteractions
CHRNA7 1139 ND0801 CHEMBL3707316 agonist ChemblInteractions
CHRNA7 1139 BUTALBITAL CHEMBL454 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 SECOBARBITAL CHEMBL447 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 METHARBITAL CHEMBL450 antagonist TdgClinicalTrial, TEND, DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 AMOBARBITAL CHEMBL267894 antagonist DrugBank 10487207, 11264449, 16248797
CHRNA7 1139 AZD0328 CHEMBL2151437 agonist GuideToPharmacologyInteractions, ChemblInteractions
CHRNA7 1139 CHEMBL195345 CHEMBL195345 agonist GuideToPharmacologyInteractions
CHRNA7 1139 CHEMBL490153 CHEMBL490153 allosteric modulator GuideToPharmacologyInteractions
CHRNA7 1139 IVERMECTIN CHEMBL1200633 allosteric modulator GuideToPharmacologyInteractions
CHRNA7 1139 CHEMBL407217 CHEMBL407217 allosteric modulator GuideToPharmacologyInteractions
CHRNA7 1139 LOXAPINE CHEMBL831 antagonist GuideToPharmacologyInteractions
CHRNA7 1139 METHYLLYCACONITINE CHEMBL510275 antagonist GuideToPharmacologyInteractions
CHRNA7 1139 ABT-107 CHEMBL2151570 agonist ChemblInteractions
CHRNA7 1139 ABT-126 CHEMBL3545231 agonist ChemblInteractions
CHRNA7 1139 TENOCYCLIDINE CHEMBL279676 antagonist DrugBank 11551210

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CHRNA7 rs2337980 CC nicotine efficacy yes Study looked at the effect of nicotine on performance in attention-related tasks. Participants with the CC genotype showed an improved performance when treated with nicotine compared to placebo, while participants with the CT or TT genotypes showed no significant change in performance between nicotine and placebo. Genotype CC is associated with increased response to nicotine in women as compared to genotypes CT + TT. 20231857 1450812627
CHRNA7 rs883473 A nicotine efficacy no Study looked at the effect of nicotine on performance in attention-related tasks. Please note that alleles have been complemented to the positive strand. Allele A is not associated with response to nicotine in women as compared to allele G. 20231857 1450812676
CHRNA7 rs6494223 T donepezil efficacy yes In patients with mild Alzheimer's disease only (baseline Mini-Mental State Examination (MMSE) score >= 20); in patients with moderate to severe Alzheimer's (MMSE <20) no significant results were seen (p=0.73). Adjusted for gender, age, baseline MMSE, and presence of the APOE E4 allele. After 6 months of treatment with cholinesterase inhibitors, those with the T allele were more likely to be a responder to treatment, as compared to those without the T allele. A responder was defined as a patient who showed improvement or no deterioration in cognition comparing MMSE scores at baseline with MMSE scores after 6 months. The authors note in the Discussion section that after 24 months of treatment, no significant association was seen. Allele T is associated with increased response to donepezil, galantamine and rivastigmine in people with Alzheimer Disease as compared to allele C. 24951635 1184747986