PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATR	6	RPA1	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Pabla N (2008), Marechal A (2014)	3
HELQ	4	FANCI	1	affinity chromatography technology	Adelman CA (2013)	1
RAD51B	1	XRCC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miller KA (2002), Huttlin EL (2015), Huttlin EL (2017)	3
FANCD2	3	POLN	4	imaging technique, affinity chromatography technology	Park HK (2010), Moldovan GL (2010)	2
RAD51C	1	RAD51B	1	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hussain S (2004), Sigurdsson S (2001), Miller KA (2002), Miller KA (2002), Miller KA (2002), Park JY (2014)	6
ATR	6	FANCI	1	enzymatic study	Shigechi T (2012)	1
RAD51B	1	RAD51D	1	affinity chromatography technology	Miller KA (2002)	1
XRCC2	0	RAD51D	1	two hybrid, two hybrid, pull down, far western blotting, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Schild D (2000), Braybrooke JP (2003), Braybrooke JP (2003), Braybrooke JP (2003), Hussain S (2004), Liu N (2002), Schild D (2000), Rolland T (2014), Huttlin EL (2015), Yard BD (2016), Yard BD (2016), Huttlin EL (2017)	12
HELQ	4	RAD51D	1	affinity chromatography technology	Adelman CA (2013)	1
RPA1	0	DHX9	3	affinity chromatography technology	Marechal A (2014)	1
RAD51C	1	RAD51D	1	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology	Miller KA (2002), Liu N (2002), Yard BD (2016), Yard BD (2016), Park JY (2014)	5
HELQ	4	RAD51C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Adelman CA (2013), Adelman CA (2013), Adelman CA (2013)	3
HELQ	4	RPA1	0	affinity chromatography technology, affinity chromatography technology	Adelman CA (2013), Adelman CA (2013)	2
FANCI	1	FANCD2	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid	Yuan F (2009), Ishiai M (2008), Sims AE (2007), Rego MA (2012), Longerich S (2014), Polito D (2014), Wang D (2016), Oka Y (2015), Oka Y (2015), Oka Y (2015), Oka Y (2015), Unno J (2014), Long DT (2011), Sato K (2014), Sato K (2014), Takahashi D (2014), Gwon GH (2014), Lossaint G (2013), Siddiqui MQ (2017), Inano S (2017)	20
HELQ	4	ATR	6	affinity chromatography technology, affinity chromatography technology	Adelman CA (2013), Adelman CA (2013)	2
POLN	4	HELQ	4	affinity chromatography technology, affinity chromatography technology	Moldovan GL (2010), Moldovan GL (2010)	2
DHX9	3	HELQ	4	biochemical	Havugimana PC (2012)	1
ATR	6	FANCD2	3	enzymatic study, imaging technique, enzymatic study	Ho GP (2006), Pichierri P (2004), Shigechi T (2012)	3
HELQ	4	RAD51B	1	affinity chromatography technology, affinity chromatography technology	Adelman CA (2013), Adelman CA (2013)	2
ATR	6	POLN	4	enzymatic study	Goehler T (2011)	1
HELQ	4	XRCC2	0	affinity chromatography technology	Adelman CA (2013)	1
FANCD2	3	RPA1	0	affinity chromatography technology	Unno J (2014)	1
HELQ	4	FANCD2	3	affinity chromatography technology, affinity chromatography technology	Adelman CA (2013), Adelman CA (2013)	2
RAD51C	1	XRCC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miller KA (2002), Liu N (2002), Huttlin EL (2015), Huttlin EL (2017), Park JY (2014)	5
DHX16	5	HELQ	4	biochemical	Havugimana PC (2012)	1
POLN	4	FANCI	1	affinity chromatography technology	Moldovan GL (2010)	1