PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCOR	2	HDAC3	5	affinity chromatography technology	Huynh KD (2000)	1
BCOR	2	BCL6	6	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology	Huynh KD (2000), Huynh KD (2000), Huynh KD (2000), Yamamoto Y (2010), Ghetu AF (2008), Ghetu AF (2008), Ng D (2004), Hatzi K (2013), Hatzi K (2013), Hein MY (2015)	10
TRIM25	5	BCOR	2	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	STRN3	3	affinity chromatography technology	Kirli K (2015)	1
BCL6	6	PML	7	two hybrid	Dhordain P (2000)	1
HDAC4	10	PRKN	1	affinity chromatography technology	Um JW (2006)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
NACC1	9	BCL6	6	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
NACC1	9	NACC1	9	affinity chromatography technology, x-ray crystallography	Nakayama K (2006), Stead MA (2009)	2
NACC1	9	KLHL2	0	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
FOXA1	2	NACC1	9	affinity chromatography technology	Li X (2015)	1
TRIM25	5	CUL4A	2	affinity chromatography technology	Choudhury NR (2017)	1
BCOR	2	HDAC4	10	affinity chromatography technology	Huynh KD (2000)	1
UBE2I	0	NACC1	9	enzymatic study, affinity chromatography technology	Tatemichi Y (2015), Tatemichi Y (2015)	2
HDAC4	10	HDAC3	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Grozinger CM (1999), Fischle W (2002), Fischle W (2002), Fischle W (2002), Fischle W (2001), Grozinger CM (2000), Wang X (2008)	7
NACC1	9	ZBTB14	2	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
NACC1	9	ENC1	0	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
SENP1	0	NACC1	9	enzymatic study	Tatemichi Y (2015)	1
KPNA4	0	NACC1	9	affinity chromatography technology	Okazaki K (2012)	1
CUL3	17	KPNA4	0	affinity chromatography technology	Bennett EJ (2010)	1
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
CUL3	17	KPNA3	0	affinity chromatography technology	Bennett EJ (2010)	1
PML	7	HDAC3	5	affinity chromatography technology, pull down	Wu WS (2001), Wu WS (2001)	2
UBE2I	0	XPO1	8	biochemical	Havugimana PC (2012)	1
MAP3K5	1	NACC1	9	affinity chromatography technology	So J (2015)	1
BCL6	6	HDAC4	10	affinity chromatography technology, pull down, affinity chromatography technology	Lemercier C (2002), Lemercier C (2002), Miles RR (2005)	3
TRIM25	5	NACC1	9	affinity chromatography technology	Choudhury NR (2017)	1
STRN3	3	NACC1	9	bioid	Couzens AL (2013)	1
TRIM25	5	STRN3	3	affinity chromatography technology	Choudhury NR (2017)	1
FOXA1	2	KPNA4	0	affinity chromatography technology	Jozwik KM (2016)	1
HDAC3	5	BCL6	6	imaging technique, affinity chromatography technology, affinity chromatography technology	Xu F (2016), Xu F (2016), Xu F (2016)	3
HDAC4	10	FOXP3	1	imaging technique	Liu R (2009)	1
KPNA3	0	KPNA4	0	biochemical	Wan C (2015)	1
CUL3	17	TARDBP	4	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	NACC1	9	affinity chromatography technology	Kirli K (2015)	1
SENP1	0	PML	7	enzymatic study	Galisson F (2011)	1
CUL3	17	BCL6	6	affinity chromatography technology	Mathew R (2014)	1
FOXP3	1	NACC1	9	affinity chromatography technology	Li X (2015)	1
NACC1	9	HDAC3	5	two hybrid, pull down, affinity chromatography technology, pull down	Korutla L (2005), Korutla L (2005), Korutla L (2005), Korutla L (2005)	4
FOXA1	2	XPO1	8	affinity chromatography technology	Jozwik KM (2016)	1
PML	7	NACC1	9	pull down	Tatemichi Y (2015)	1
MRPL43	0	NACC1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKN	1	TARDBP	4	imaging technique, affinity chromatography technology	Hebron M (2013), Zhu X (2017)	2
FOXJ2	3	NACC1	9	affinity chromatography technology	Li X (2015)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	RBPJ	1	affinity chromatography technology	Kirli K (2015)	1
SENP2	3	NACC1	9	enzymatic study	Tatemichi Y (2015)	1
ITLN1	0	NACC1	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NACC1	9	TARDBP	4	pull down, pull down	Scofield M (2012), Scofield M (2012)	2
PRKN	1	PSMD7	1	affinity chromatography technology	Sarraf SA (2013)	1
NACC1	9	BCOR	2	affinity chromatography technology, two hybrid	Korutla L (2009), Korutla L (2009)	2
BCOR	2	SENP2	3	affinity chromatography technology	Oliviero G (2015)	1
UBE2I	0	HDAC4	10	enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Knipscheer P (2008), Zhao X (2005), Zhao X (2005), Dehennaut V (2013), Tatham MH (2001), Knipscheer P (2007)	6
RBPJ	1	NACC1	9	affinity chromatography technology	Li X (2015)	1
NACC1	9	ZBTB6	0	two hybrid, affinity chromatography technology	Korutla L (2009), Korutla L (2009)	2
FOXA2	3	NACC1	9	affinity chromatography technology	Li X (2015)	1
HDAC3	5	XPO1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang WM (2002), Lai IL (2007), Kirli K (2015)	3
HDAC4	10	SENP1	0	imaging technique	Maciejewska-Rodrigues H (2010)	1
ENC1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Bennett EJ (2010), Huttlin EL (2017)	3
FOXA1	2	TARDBP	4	affinity chromatography technology	Jozwik KM (2016)	1
NACC1	9	PSMD7	1	affinity chromatography technology	Shen H (2007)	1
KPNA3	0	NACC1	9	affinity chromatography technology	Okazaki K (2012)	1
MATN4	1	NACC1	9	affinity chromatography technology	Huttlin EL (2017)	1
NACC1	9	CUL4A	2	affinity chromatography technology	Shen H (2007)	1
TRIM25	5	TARDBP	4	affinity chromatography technology	Choudhury NR (2017)	1
ZBTB9	0	NACC1	9	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	KLHL2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bennett EJ (2010), Takahashi D (2013), Rolland T (2014), Huttlin EL (2017)	4
TRIM25	5	PML	7	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	NACC1	9	affinity chromatography technology, affinity chromatography technology	Korutla L (2013), Korutla L (2013)	2
DUSP13	1	NACC1	9	affinity chromatography technology	Li X (2016)	1
NACC1	9	CUL3	17	affinity chromatography technology, affinity chromatography technology	Shen H (2007), Shen H (2007)	2
NACC1	9	HDAC4	10	two hybrid, pull down, affinity chromatography technology, pull down	Korutla L (2005), Korutla L (2005), Korutla L (2005), Korutla L (2005)	4