PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KAT2B	2	KLF8	0	affinity chromatography technology	Urvalek AM (2010)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
KLF8	0	XPO1	8	affinity chromatography technology	Lu H (2011)	1
EP300	36	PARP1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2009), Hassa PO (2005), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008), Hassa PO (2003), Hassa PO (2003), Hassa PO (2003), Kim BK (2014), Kim BK (2014)	11
CTBP1	2	CREBBP	29	affinity chromatography technology, pull down	Senyuk V (2005), Kim JH (2005)	2
KLF8	0	DGCR8	4	affinity chromatography technology	Hein MY (2015)	1
EP300	36	KLF8	0	affinity chromatography technology	Urvalek AM (2010)	1
KLF8	0	BIN1	2	affinity chromatography technology	Hein MY (2015)	1
DGCR8	4	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	ANTXR1	3	affinity chromatography technology	Fei T (2017)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
KLF8	0	CTBP1	2	affinity chromatography technology, affinity chromatography technology	Urvalek AM (2011), Urvalek AM (2011)	2
KLF8	0	MICALL1	1	affinity chromatography technology	Hein MY (2015)	1
KAT2B	2	PARP1	3	enzymatic study	Rajamohan SB (2009)	1
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
CTBP2	7	KLF8	0	two hybrid, pull down	van Vliet J (2000), van Vliet J (2000)	2
CTBP1	2	KAT2B	2	enzymatic study, affinity chromatography technology, pull down	Fuks F (1998), Senyuk V (2005), Kim JH (2005)	3
KLF8	0	ANTXR1	3	affinity chromatography technology	Hein MY (2015)	1
KAT2B	2	CTBP2	7	affinity chromatography technology	Shimahara A (2010)	1
CTBP2	7	APP	1	pull down	Olah J (2011)	1
CREBBP	29	KLF8	0	affinity chromatography technology	Urvalek AM (2010)	1
KLF8	0	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	CTBP1	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	CTBP2	7	affinity chromatography technology	Fei T (2017)	1
KLF8	0	PARP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique	Lu H (2011), Lu H (2011), Lu H (2011), Lu H (2011), Lu H (2011)	5
HNRNPL	3	KLF8	0	affinity chromatography technology	Fei T (2017)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
BIN1	2	APP	1	pull down	Olah J (2011)	1
CREBBP	29	PARP1	3	enzymatic study, imaging technique	Hassa PO (2005), Chen H (2014)	2
KLF8	0	SGSM3	5	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
CTBP1	2	EP300	36	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Senyuk V (2005), Kim JH (2005), Kim JH (2005), Kim JH (2005)	4
HNRNPL	3	CREBBP	29	affinity chromatography technology	Fei T (2017)	1
CTBP2	7	EP300	36	affinity chromatography technology	Zhao LJ (2009)	1