Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
STX1B	rs4889606	AG + GG	warfarin	dosage	yes	in both European-Americans, and Egyptians. "However, STX1B rs4889606 was in high linkage disequilibrium with VKORC1-1639 G>A, and was no longer significant after including VKORC1-1639 G>A in the regression model. Based on these data, the polymorphisms do not appear to influence, in a clinically important way, warfarin dose requirements in European-Americans and Egyptians. "	Genotypes AG + GG are associated with decreased dose of warfarin as compared to genotype AA.	26751406	1447677865
STX1B	rs72800847	AA + AG	warfarin	dosage	yes	All participants were warfarin-naive.	Genotypes AA + AG is associated with decreased dose of warfarin in people with heart valve replacement as compared to genotype GG.	27740732	1448267343
STX1B	rs4889606	AG + GG	warfarin	dosage	yes	in African american patients even after conditioning on VKORC1 -1639G>A (rs9923231) variant. "Inclusion of rs4889606 genotypes, along with CYP2C9 alleles, rs9923231 genotypes, and clinical variables explained 31% of the interpatient variability in warfarin dose requirement." "The daily warfarin dose was significantly different among the three genotypes of rs4889606 with carriers of the AG or GG genotypes requiring higher doses (6.8 ±3.1 mg/day and 7.6 ±3.9 mg/day, respectively) compared to AA carriers in the Discovery (ß = 1.1; 95%CI = 0.46 – 1.8, p = 0.0009)".	Genotypes AG + GG are associated with increased dose of warfarin as compared to genotype AA.	28135054	1448573185