PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NXF1	0	USP18	1	affinity chromatography technology	Castello A (2012)	1
IKBKB	1	MAP3K7	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofer-Warbinek R (2000), Wu ZH (2010), Wu ZH (2010), Prickett TD (2008), Fan YH (2011), Neil JR (2008), Wu X (2007), Shambharkar PB (2007), Shambharkar PB (2007), Niu J (2013), Yao F (2015), Yao F (2015), Mei ZZ (2016), Zheng C (2015)	14
TAB1	1	CARD11	4	two hybrid	Vinayagam A (2011)	1
IKBKB	1	USP18	1	affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Yang Z (2015)	2
ATG14	1	PIK3C3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Matsunaga K (2009), Gammoh N (2013), Ma B (2014), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Huttlin EL (2017), Stjepanovic G (2017), Liu X (2017)	12
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
BCL2L1	0	BECN1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liang XH (1998), Wang J (2008), Wang J (2008), Tang Y (2012), Noble CG (2008), Noble CG (2008), Pimkina J (2009), Pimkina J (2009), Zalckvar E (2009), Luo S (2010)	10
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
TAB2	5	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Li S (2011), Li S (2011), Mendoza H (2008), Shin MS (2009), Suzuki S (2007), Jiang Z (2002), Wang J (2011), Xia ZP (2009), Charlaftis N (2014), St-Denis N (2016)	14
USP18	1	373856	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
CHUK	5	CARD11	4	affinity chromatography technology, imaging technique	McCully RR (2008), Sommer K (2005)	2
USP18	1	CARD11	4	affinity chromatography technology	Liu X (2013)	1
NXF1	0	SKP2	2	affinity chromatography technology	Castello A (2012)	1
PIK3C3	1	USP18	1	affinity chromatography technology	Xu D (2015)	1
CHUK	5	TAB2	5	affinity chromatography technology	Kishida S (2005)	1
USP18	1	TAB2	5	affinity chromatography technology	Liu X (2013)	1
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
BECN1	2	PIK3C3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Platta HW (2012), Platta HW (2012), Platta HW (2012), Wang J (2008), Xia P (2013), Luciani A (2010), Luciani A (2010), Matsunaga K (2009), Ma B (2014), Xia P (2014), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Pattingre S (2005), Luo S (2010), Ramachandran N (2013), Fogel AI (2013), Xu D (2015), Hein MY (2015), Ma B (2015), Zeng X (2006), Verma N (2017), Wei Y (2015), Stjepanovic G (2017), Liu X (2017), Li X (2017)	30
MAP3K7	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Sakurai H (1999), Ninomiya-Tsuji J (1999), Lin X (1998), Lin X (1998), Ear T (2010), Huangfu WC (2006), Chen TC (2014)	7
IKBKG	0	CARD11	4	pull down, affinity chromatography technology, affinity chromatography technology	Stilo R (2004), McCully RR (2008), Shambharkar PB (2007)	3
USP18	1	IFNAR2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malakhova OA (2006), Malakhova OA (2006), Ganesan M (2016)	3
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
CHUK	5	USP18	1	affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Yang Z (2015)	2
MAP3K7	2	USP18	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Liu X (2013), An S (2017), An S (2017)	4
MAP3K7	2	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016)	4
MOV10	6	USP18	1	affinity chromatography technology	Castello A (2012)	1
USP18	1	HERC1	12	affinity chromatography technology	Huttlin EL (2015)	1
TRIM54	1	USP18	1	enzymatic study	Loch CM (2012)	1
USP18	1	PCNA	0	affinity chromatography technology, affinity chromatography technology	Park JM (2014), Park JM (2014)	2
TAB1	1	USP18	1	affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Liu X (2013)	2
TAB1	1	IKBKB	1	affinity chromatography technology	Neil JR (2008)	1
USP18	1	MYL6	2	affinity chromatography technology	Sowa ME (2009)	1
USP18	1	KDM3B	9	affinity chromatography technology	Sowa ME (2009)	1
NXF1	0	TAB1	1	affinity chromatography technology	Castello A (2012)	1
USP18	1	NME1	0	affinity chromatography technology	Sowa ME (2009)	1
USP18	1	BCL2L1	0	affinity chromatography technology, affinity chromatography technology	Cai J (2017), Cai J (2017)	2
USP18	1	TMEM173	0	affinity chromatography technology, affinity chromatography technology	Zhang M (2016), Zhang M (2016)	2
IKBKG	0	USP18	1	affinity chromatography technology, affinity chromatography technology	Yang Z (2015), Yang Z (2015)	2
USP18	1	TMEM14A	1	two hybrid	Yu H (2011)	1
UVRAG	2	USP18	1	affinity chromatography technology	Xu D (2015)	1
TAB2	5	BECN1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Criollo A (2011), Takaesu G (2012), Takaesu G (2012), Takaesu G (2012)	4
ISG15	0	USP18	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Zhang X (2014), Rolland T (2014)	3
MOV10	6	TAB1	1	affinity chromatography technology	Castello A (2012)	1
MAP3K7	2	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Channavajhala PL (2003), Ninomiya-Tsuji J (1999), Sakurai H (2000), Liu XY (2008), Li S (2011), Li S (2011), Ear T (2010), Singhirunnusorn P (2005), Prickett TD (2008), Kim SY (2012), Jiang Z (2002), Shibuya H (1996), Shibuya H (1996), Minoda Y (2009), Minoda Y (2009), Scholz R (2010), Scholz R (2010), Scholz R (2010), Kim SI (2009), Ge B (2003), Blonska M (2005), Kishimoto K (2000), Kishimoto K (2000), Zhu Y (2013), Liu R (2014), Chen TC (2014), Moon G (2015), Ninomiya-Tsuji J (2003), Min Y (2016), St-Denis N (2016), Zhang J (2017)	33
ZDHHC17	1	USP18	1	two hybrid	Butland SL (2014)	1
BECN1	2	USP18	1	affinity chromatography technology	Xu D (2015)	1
SKP2	2	USP18	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Tokarz S (2004), Tokarz S (2004), Tokarz S (2004), Zhang X (2014)	4
ATG14	1	USP18	1	affinity chromatography technology	Xu D (2015)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
MOV10	6	KDM3B	9	affinity chromatography technology	Castello A (2012)	1
BECN1	2	ATG14	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Luciani A (2010), Luciani A (2010), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Ma B (2014), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Fogel AI (2013), Hein MY (2015), Chauhan S (2015), Wei Y (2015), Huttlin EL (2017), Stjepanovic G (2017), Liu X (2017), Liu X (2017)	24
TAB2	5	IKBKB	1	enzymatic study	Niu J (2011)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
BECN1	2	UVRAG	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Matsunaga K (2009), Noble CG (2008), Itakura E (2008), Itakura E (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Sun Q (2008), Fogel AI (2013), Hein MY (2015), Yang Y (2016)	16
IKBKG	0	TAB1	1	pull down	Emmerich CH (2013)	1
PIK3C3	1	UVRAG	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Behrends C (2010), Ma B (2014), Itakura E (2008), Itakura E (2008)	5