PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
TRIM25	5	RAI14	4	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN1	0	COBL	4	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2017)	2
PTPN12	2	UGP2	2	biochemical	Kristensen AR (2012)	1
PACSIN2	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
TERF2IP	1	POT1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Ye JZ (2004), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	5
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
PTGES3	0	PACSIN2	0	biochemical	Wan C (2015)	1
PACSIN1	0	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
CDH1	4	SYNJ1	3	bioid	Guo Z (2014)	1
PACSIN2	0	KHDRBS1	1	affinity chromatography technology	Linkermann A (2009)	1
HSPD1	0	HSPA8	4	biochemical	Havugimana PC (2012)	1
PACSIN2	0	MPRIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN3	2	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
MOV10	6	GTF2E2	2	affinity chromatography technology	Castello A (2012)	1
PTPN12	2	PACSIN2	0	biochemical	Kristensen AR (2012)	1
CDH1	4	COBLL1	3	bioid	Guo Z (2014)	1
POT1	2	PACSIN2	0	two hybrid	Lee OH (2011)	1
TRIM25	5	KHDRBS1	1	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN2	0	PACSIN1	0	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Bandyopadhyay S (2010), Rolland T (2014), Huttlin EL (2017)	8
PACSIN2	0	HSPD1	0	biochemical	Wan C (2015)	1
PACSIN3	2	COBLL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN2	0	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	CYFIP2	7	affinity chromatography technology	Linkermann A (2009)	1
TERF1	1	THG1L	1	two hybrid	Lee OH (2011)	1
PACSIN2	0	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN1	0	CARS	1	affinity chromatography technology	Linkermann A (2009)	1
ST13	2	PACSIN3	2	biochemical	Wan C (2015)	1
PTPN12	2	ANKS1A	3	biochemical	Kristensen AR (2012)	1
PACSIN2	0	PACSIN2	0	two hybrid, pull down, two hybrid, two hybrid	Rual JF (2005), Modregger J (2000), Modregger J (2000), Rolland T (2014)	4
UGP2	2	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
PACSIN3	2	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
COL4A3BP	18	PACSIN2	0	biochemical	Kristensen AR (2012)	1
CDH1	4	MICALL1	1	bioid	Guo Z (2014)	1
CDH1	4	ASAP1	1	bioid	Guo Z (2014)	1
TRIM25	5	ASAP1	1	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN2	0	COBLL1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNM2	2	DNM1	21	two hybrid	Vinayagam A (2011)	1
CDH1	4	PACSIN2	0	bioid	Guo Z (2014)	1
ST13	2	PACSIN2	0	biochemical	Wan C (2015)	1
PACSIN2	0	PACSIN3	2	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Huttlin EL (2015), Huttlin EL (2017)	5
WASL	2	WIPF2	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
PACSIN3	2	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
CDH1	4	MPRIP	2	bioid	Guo Z (2014)	1
PACSIN2	0	THG1L	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN2	0	MICALL1	1	affinity chromatography technology	Linkermann A (2009)	1
GTF2E2	2	UGP2	2	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN2	0	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	SBK1	0	affinity chromatography technology	Linkermann A (2009)	1
PACSIN3	2	MICALL1	1	affinity chromatography technology, affinity chromatography technology	Linkermann A (2009), Huttlin EL (2017)	2
TRIM25	5	COBL	4	affinity chromatography technology	Choudhury NR (2017)	1
POT1	2	PACSIN1	0	two hybrid	Lee OH (2011)	1
PACSIN3	2	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
MEOX2	2	PACSIN2	0	two hybrid	Rolland T (2014)	1
CDH1	4	HSPA8	4	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
EWSR1	2	PTGES3	0	bioid	Elzi DJ (2014)	1
TRIM25	5	WIPF2	1	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN2	0	ANKS1A	3	biochemical	Kristensen AR (2012)	1
TRIM25	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
PACSIN2	0	SWAP70	2	biochemical	Kristensen AR (2012)	1
TRIM25	5	ANKS1A	3	affinity chromatography technology	Choudhury NR (2017)	1
ERP44	1	PACSIN2	0	affinity chromatography technology	Hein MY (2015)	1
PACSIN2	0	DNM1	21	pull down	Modregger J (2000)	1
MOV10	6	PACSIN2	0	affinity chromatography technology	Castello A (2012)	1
PACSIN1	0	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	APBB1IP	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN3	2	CARS	1	affinity chromatography technology	Linkermann A (2009)	1
POT1	2	HSPA1A	0	two hybrid	Lee OH (2011)	1
TRIM25	5	GTF2E2	2	affinity chromatography technology	Choudhury NR (2017)	1
TERF1	1	PACSIN2	0	two hybrid	Lee OH (2011)	1
NXF1	0	PACSIN2	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	GTF2E2	2	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Pauli EK (2014), Choudhury NR (2017)	2
PACSIN3	2	CYFIP2	7	affinity chromatography technology	Linkermann A (2009)	1
CDH1	4	SWAP70	2	bioid	Guo Z (2014)	1
PACSIN2	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
FTL	0	COL4A3BP	18	biochemical	Kristensen AR (2012)	1
WASL	2	WIPF1	0	pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Zettl M (2002), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Martinez-Quiles N (2001), Rolland T (2014), Huttlin EL (2017)	6
PACSIN1	0	COBLL1	3	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Huttlin EL (2017)	2
PACSIN1	0	APBB1IP	1	affinity chromatography technology	Linkermann A (2009)	1
FTL	0	PACSIN2	0	biochemical	Kristensen AR (2012)	1
TRIM25	5	CARS	1	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN2	0	COBL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TMEM17	0	PACSIN2	0	bioid	Gupta GD (2015)	1
EWSR1	2	PACSIN2	0	affinity chromatography technology	Elzi DJ (2014)	1
COL4A3BP	18	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
PACSIN2	0	WASL	2	pull down	Modregger J (2000)	1
CDH1	4	WIPF2	1	bioid	Guo Z (2014)	1
PACSIN3	2	SBK1	0	affinity chromatography technology	Linkermann A (2009)	1
CDH1	4	HSPA1A	0	bioid	Guo Z (2014)	1
PACSIN3	2	WASL	2	pull down	Modregger J (2000)	1
TRIM25	5	PACSIN2	0	affinity chromatography technology	Choudhury NR (2017)	1
CDH1	4	RAI14	4	bioid	Guo Z (2014)	1
PPP2R5C	3	SWAP70	2	biochemical	Kristensen AR (2012)	1
PTPN12	2	ASAP1	1	bioid	St-Denis N (2016)	1
TRIM25	5	PTGES3	0	affinity chromatography technology	Choudhury NR (2017)	1
WAS	0	WIPF1	0	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid	Ramesh N (1997), Ramesh N (1997), Ramesh N (1997), Anton IM (1998), Wang J (2011), Rolland T (2014)	6
PACSIN3	2	SYNJ1	3	pull down	Modregger J (2000)	1
PACSIN1	0	MPRIP	2	affinity chromatography technology	Huttlin EL (2017)	1
KHDRBS1	1	POT1	2	two hybrid	Wang J (2011)	1
PACSIN2	0	CARS	1	affinity chromatography technology	Linkermann A (2009)	1
PLOD2	2	VASN	2	biochemical	Kristensen AR (2012)	1
WAS	0	WIPF2	1	affinity chromatography technology, two hybrid	Aspenstroem P (2002), Wang J (2011)	2
TERF1	1	TERF2IP	1	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015)	6
SHBG	0	PACSIN2	0	two hybrid	Pope SN (2005)	1
TERF2IP	1	PACSIN3	2	two hybrid	Lee OH (2011)	1
PACSIN1	0	SYNJ1	3	pull down	Modregger J (2000)	1
TRIM25	5	MICALL1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PPP2R5C	3	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN2	0	WIPF2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PACSIN1	0	WIPF1	0	affinity chromatography technology	Linkermann A (2009)	1
TERF2IP	1	PACSIN2	0	two hybrid	Lee OH (2011)	1
TERF1	1	PLOD2	2	affinity chromatography technology	Giannone RJ (2010)	1
PACSIN3	2	COBL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH1	4	HSPD1	0	affinity chromatography technology	Catimel B (2005)	1
MOV10	6	HSPD1	0	affinity chromatography technology	Castello A (2012)	1
VASN	2	PACSIN2	0	biochemical	Kristensen AR (2012)	1
TRIM25	5	HSPD1	0	affinity chromatography technology	Choudhury NR (2017)	1
PLOD2	2	SWAP70	2	biochemical	Kristensen AR (2012)	1
ST13	2	HSPA1A	0	pull down	Prapapanich V (1996)	1
PACSIN2	0	SYNJ1	3	pull down	Modregger J (2000)	1
PTPN12	2	VASN	2	biochemical	Kristensen AR (2012)	1
PACSIN1	0	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
ST13	2	HSPA8	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Velten M (2002), Tsukahara F (2000), Taipale M (2014), Taipale M (2014)	4
POT1	2	TERF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loayza D (2003), Giannone RJ (2010), Giannone RJ (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	7
PACSIN1	0	WASL	2	pull down	Modregger J (2000)	1
UGP2	2	PLOD2	2	biochemical	Kristensen AR (2012)	1
PACSIN1	0	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
HSPD1	0	PACSIN3	2	biochemical	Wan C (2015)	1
PACSIN3	2	DNM1	21	pull down	Modregger J (2000)	1
TRIM25	5	PTPN12	2	affinity chromatography technology	Choudhury NR (2017)	1
EWSR1	2	KHDRBS1	1	bioid	Elzi DJ (2014)	1
PACSIN1	0	MICALL1	1	affinity chromatography technology	Linkermann A (2009)	1
TRIM25	5	MPRIP	2	affinity chromatography technology	Choudhury NR (2017)	1
PACSIN3	2	KHDRBS1	1	affinity chromatography technology, biochemical	Linkermann A (2009), Wan C (2015)	2
UGP2	2	PACSIN2	0	biochemical	Kristensen AR (2012)	1
PACSIN3	2	ASAP1	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN2	0	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
PACSIN1	0	KHDRBS1	1	affinity chromatography technology, unspecified method	Linkermann A (2009), Asbach B (2012)	2
UGP2	2	VASN	2	biochemical	Kristensen AR (2012)	1
PACSIN1	0	PACSIN3	2	two hybrid, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Modregger J (2000), Modregger J (2000), Modregger J (2000), Modregger J (2000), Rolland T (2014), Huttlin EL (2017)	6
GTF2E2	2	PACSIN2	0	affinity chromatography technology	Huttlin EL (2017)	1
NXF1	0	HSPD1	0	affinity chromatography technology	Castello A (2012)	1
PLOD2	2	PACSIN2	0	biochemical	Kristensen AR (2012)	1
DNM1	21	PACSIN1	0	affinity chromatography technology, pull down	Kamioka Y (2004), Modregger J (2000)	2
PACSIN3	2	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
PACSIN3	2	HSPA8	4	affinity chromatography technology	Linkermann A (2009)	1
HSPD1	0	FTL	0	biochemical	Havugimana PC (2012)	1
PACSIN3	2	APBB1IP	1	affinity chromatography technology	Linkermann A (2009)	1
PACSIN1	0	HSPA1A	0	affinity chromatography technology	Linkermann A (2009)	1
HSPD1	0	HSPA1A	0	biochemical	Havugimana PC (2012)	1
PACSIN1	0	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
TMEM17	0	RAI14	4	bioid	Gupta GD (2015)	1
CDH1	4	VASN	2	bioid	Guo Z (2014)	1
PACSIN1	0	CYFIP2	7	affinity chromatography technology	Linkermann A (2009)	1
PTPN12	2	PLOD2	2	biochemical	Kristensen AR (2012)	1
TRIM25	5	DNM2	2	affinity chromatography technology	Choudhury NR (2017)	1
GTF2E2	2	DNM2	2	affinity chromatography technology	Jeronimo C (2007)	1
FASLG	0	PACSIN2	0	affinity chromatography technology, pull down, affinity chromatography technology	Ghadimi MP (2002), Ghadimi MP (2002), Ghadimi MP (2002)	3