PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SERPINB9	0	PRPF40A	5	two hybrid	Stelzl U (2005)	1
BARD1	4	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Dong Y (2003), Dong Y (2003), Feki A (2005), Jiang J (2011), Tembe V (2015), Tembe V (2015), Tembe V (2015)	7
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
UBC	7	ELL	4	pull down	Nathan JA (2013)	1
ZHX1	1	ZHX3	1	two hybrid, two hybrid, pull down	Yamada K (2003), Yamada K (2003), Yamada K (2003)	3
ELAVL1	0	ZMYND11	10	affinity chromatography technology	Abdelmohsen K (2009)	1
PAFAH1B3	1	TP53	0	two hybrid	Stelzl U (2005)	1
CHD3	19	ZHX1	1	two hybrid	Goehler H (2004)	1
SAT1	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
ATXN1	2	ZHX3	1	two hybrid	Lim J (2006)	1
CREB1	1	TP53	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Giebler HA (2000), Giebler HA (2000), Giebler HA (2000), Okoshi R (2011), Borger DR (2006), Chen TC (2014)	6
AKR1C3	1	ZHX1	1	two hybrid	Stelzl U (2005)	1
BHLHE40	5	CHD3	19	two hybrid	Stelzl U (2005)	1
GADD45A	1	CHD3	19	two hybrid	Vinayagam A (2011)	1
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
SUMO2	0	ZHX1	1	two hybrid	Hecker CM (2006)	1
PAFAH1B3	1	ZHX1	1	two hybrid	Stelzl U (2005)	1
GNG11	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
ZHX1	1	PIAS4	5	two hybrid	Goehler H (2004)	1
GADD45A	1	VIM	0	two hybrid	Vinayagam A (2011)	1
UBC	7	CHD3	19	pull down	Nathan JA (2013)	1
BCL2L1	0	ZHX1	1	two hybrid	Vinayagam A (2011)	1
WDR33	3	ZHX1	1	two hybrid	Stelzl U (2005)	1
NFYA	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imbriano C (2005), Imbriano C (2005), Imbriano C (2005), Di Agostino S (2006), Di Agostino S (2006), Huang X (2013)	6
LYAR	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
BHLHE40	5	VIM	0	two hybrid	Stelzl U (2005)	1
TOLLIP	3	ZHX1	1	two hybrid	Stelzl U (2005)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
BHLHE40	5	TP53	0	affinity chromatography technology	Thin TH (2007)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
LAMA4	8	TP53	0	two hybrid, imaging technique	Stelzl U (2005), Chen TC (2014)	2
ZHX1	1	ZHX1	1	two hybrid, two hybrid, pull down, pull down	Yamada K (2002), Yamada K (2003), Hirano S (2002), Yamada K (2002)	4
ELAVL1	0	CSNK2A1	15	affinity chromatography technology	Abdelmohsen K (2009)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
TAL1	0	CHD3	19	affinity chromatography technology, two hybrid	Hu X (2009), Goehler H (2004)	2
CHD3	19	SUMO1	0	two hybrid, pull down	Minty A (2000), Goodarzi AA (2011)	2
SUMO2	0	PIAS4	5	pull down, two hybrid, two hybrid, pull down, pull down	Goehler H (2004), Goehler H (2004), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
ELAVL1	0	ZHX1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CSNK2A1	15	AKT1	1	enzymatic study	Di Maira G (2005)	1
ATXN1	2	TOLLIP	3	two hybrid	Lim J (2006)	1
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
UBC	7	DLST	3	affinity chromatography technology	Matsumoto M (2005)	1
CREB1	1	CHD3	19	two hybrid	Stelzl U (2005)	1
ZHX1	1	ELL	4	two hybrid	Yamada K (2003)	1
VIM	0	ZYX	2	biochemical	Havugimana PC (2012)	1
CHD3	19	PRPF40A	5	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
DLST	3	ZHX1	1	two hybrid	Stelzl U (2005)	1
VIM	0	ZHX1	1	two hybrid	Goehler H (2004)	1
ZHX1	1	ZMYND11	10	two hybrid, two hybrid	Yamada K (2003), Wang J (2011)	2
ZNF33B	1	ZHX1	1	two hybrid	Goehler H (2004)	1
PNP	1	TP53	0	two hybrid	Stelzl U (2005)	1
TARDBP	4	NACA	1	affinity chromatography technology	Freibaum BD (2010)	1
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
ATXN1	2	ZYX	2	two hybrid	Lim J (2006)	1
SUMO2	0	VIM	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ZMYND11	10	UBE2I	0	two hybrid, affinity chromatography technology	Yu B (2009), Yu B (2009)	2
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
NFYA	2	ZHX1	1	two hybrid, pull down, two hybrid, pull down	Yamada K (1999), Yamada K (1999), Yamada K (1999), Yamada K (1999)	4
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
ZHX1	1	ZHX2	3	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	IDH1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BARD1	4	CHD3	19	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
SUMO1	0	TP53	0	two hybrid	Minty A (2000)	1
BARD1	4	PRPF40A	5	affinity chromatography technology	Woods NT (2012)	1
BARD1	4	WDR33	3	affinity chromatography technology	Woods NT (2012)	1
BCL2L1	0	DYNLL1	0	affinity chromatography technology	Puthalakath H (1999)	1
LAMA4	8	ZHX1	1	two hybrid	Stelzl U (2005)	1
UBC	7	NACA	1	affinity chromatography technology	Matsumoto M (2005)	1
GSK3B	1	BCL2L1	0	enzymatic study	Wang J (2012)	1
UBE2I	0	ZHX1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Chen S (2013), Chen S (2013), Chen S (2013)	4
LHX9	2	ZHX1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZHX1	1	PRPF40A	5	two hybrid	Goehler H (2004)	1
BCL2L1	0	TP53	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Vinayagam A (2011), Tang WH (2014), Saxena R (2016), Stegh AH (2010), Kim EM (2014)	5
PIAS4	5	PRPF40A	5	two hybrid	Goehler H (2004)	1
IDH1	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
UBC	7	PSMD11	0	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
GSK3B	1	ZHX1	1	two hybrid	Vinayagam A (2011)	1
CREB1	1	NFYA	2	affinity chromatography technology	Li X (2015)	1
GSK3B	1	CREB1	1	enzymatic study	Li B (2003)	1
WDR83	1	ZHX1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GSK3B	1	CHD3	19	two hybrid	Vinayagam A (2011)	1
TARDBP	4	ZHX1	1	two hybrid	Stelzl U (2005)	1
TERF1	1	LYAR	0	two hybrid	Lee OH (2011)	1
ELL	4	TP53	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Shinobu N (1999), Shinobu N (1999), Shinobu N (1999), Shinobu N (1999), Shinobu N (1999)	5
AKT1	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Zhu QS (2011), Zhu QS (2011), Zhu QS (2011), Zhu QS (2011)	4
SAT1	0	HSPE1	0	two hybrid	Stelzl U (2005)	1
NACA	1	ZHX1	1	two hybrid	Stelzl U (2005)	1
ELAVL1	0	TOLLIP	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ZHX1	1	EFNA2	3	two hybrid	Yamada K (2003)	1
GADD45A	1	TP53	0	two hybrid	Vinayagam A (2011)	1
CREB1	1	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
SUMO2	0	CHD3	19	two hybrid, two hybrid, two hybrid, unspecified method	Stelzl U (2005), Vinayagam A (2011), Goehler H (2004), Garvin AJ (2013)	4
ATXN1	2	ZHX2	3	two hybrid	Lim J (2006)	1
GSK3B	1	DYNLL1	0	affinity chromatography technology	Varjosalo M (2013)	1
MPHOSPH6	1	TP53	0	two hybrid	Stelzl U (2005)	1
ELAVL1	0	WDR33	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CREB1	1	ZHX1	1	two hybrid	Bandyopadhyay S (2010)	1
WDR33	3	TP53	0	two hybrid	Stelzl U (2005)	1
GADD45A	1	ZHX1	1	two hybrid	Vinayagam A (2011)	1
UBC	7	WDR33	3	pull down	Zhang X (2017)	1
PNP	1	ZHX1	1	two hybrid	Stelzl U (2005)	1
CSNK2A1	15	ZHX1	1	two hybrid	Stelzl U (2005)	1
GSK3B	1	TP53	0	affinity chromatography technology, two hybrid	Watcharasit P (2002), Vinayagam A (2011)	2
ATXN1	2	SUMO1	0	two hybrid	Kang S (2010)	1
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
DYNLL1	0	ELL	4	affinity chromatography technology	Hein MY (2015)	1
VIM	0	PIAS4	5	two hybrid	Goehler H (2004)	1
AKT1	1	CREB1	1	enzymatic study	Du K (1998)	1
ELAVL1	0	BHLHE40	5	affinity chromatography technology	Abdelmohsen K (2009)	1
TAL1	0	ZHX1	1	two hybrid	Goehler H (2004)	1
SERPINB9	0	TP53	0	two hybrid	Stelzl U (2005)	1
GSK3B	1	VIM	0	two hybrid	Vinayagam A (2011)	1
PSMD11	0	TP53	0	two hybrid	Stelzl U (2005)	1
ELAVL1	0	SUMO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CHD3	19	TP53	0	two hybrid, two hybrid	Minty A (2000), Goehler H (2004)	2
ELAVL1	0	BARD1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
PEX14	2	ZHX1	1	two hybrid	Stelzl U (2005)	1
SERPINB9	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
DLST	3	TP53	0	affinity chromatography technology	Malty RH (2017)	1
SAT1	0	CHD3	19	two hybrid	Stelzl U (2005)	1
BHLHE40	5	UBE2I	0	affinity chromatography technology, two hybrid	Ivanova AV (2001), Ivanova AV (2001)	2
AKT1	1	ZHX1	1	two hybrid	Vinayagam A (2011)	1
AKT1	1	BCL2L1	0	enzymatic study	Qi XJ (2006)	1
SUMO1	0	ZHX1	1	two hybrid	Hecker CM (2006)	1
UTP3	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
DYNLL1	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
PSMD11	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
BARD1	4	ZHX1	1	two hybrid	Goehler H (2004)	1
IDH1	0	HSPE1	0	biochemical	Kristensen AR (2012)	1
TP53	0	VIM	0	affinity chromatography technology	Horikawa I (2014)	1
ELAVL1	0	PIAS4	5	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
BID	1	ZHX1	1	two hybrid	Vinayagam A (2011)	1
PRPF40A	5	UBE2I	0	two hybrid	Colland F (2004)	1
TNFRSF10C	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
TOLLIP	3	BHLHE40	5	two hybrid	Bandyopadhyay S (2010)	1
PIGC	2	ZHX1	1	two hybrid	Stelzl U (2005)	1
CSNK2A1	15	NFYA	2	two hybrid	Rolland T (2014)	1
ELAVL1	0	GSK3B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ZHX1	1	ZYX	2	two hybrid	Yamada K (2003)	1
UBC	7	ZHX1	1	pull down	Nathan JA (2013)	1
CHD3	19	PIAS4	5	two hybrid	Goehler H (2004)	1
ZMYND11	10	TP53	0	affinity chromatography technology	Zhang W (2007)	1
CHD3	19	CSNK2A1	15	affinity chromatography technology	Sun JM (2007)	1
XPO4	4	ZHX1	1	biochemical	Havugimana PC (2012)	1
MPHOSPH6	1	ZHX1	1	two hybrid	Stelzl U (2005)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BARD1	4	PIAS4	5	two hybrid	Goehler H (2004)	1
TERF1	1	ZHX1	1	two hybrid	Stelzl U (2005)	1
BCL2L1	0	BID	1	unspecified method, unspecified method, unspecified method, imaging technique	Chen L (2005), Kuwana T (2005), Certo M (2006), Chen TC (2014)	4
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
TERF1	1	PAFAH1B3	1	two hybrid	Lee OH (2011)	1
SAT1	0	TP53	0	two hybrid	Stelzl U (2005)	1
CSNK2A1	15	PRPF40A	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Zhang M (2011), Huttlin EL (2015), Huttlin EL (2017)	3
ZHX2	3	ZHX3	1	pull down, pull down, two hybrid	Kawata H (2003), Kawata H (2003), Kawata H (2003)	3
SUMO1	0	PIAS4	5	two hybrid	Hecker CM (2006)	1
UBE2I	0	CHD3	19	two hybrid	Lee BH (2003)	1
CREB1	1	VIM	0	two hybrid	Stelzl U (2005)	1
ZHX1	1	ATXN1	2	two hybrid, two hybrid, affinity chromatography technology	Yamada K (2003), Lim J (2006), Lim J (2006)	3
HSPE1	0	ZHX1	1	two hybrid	Stelzl U (2005)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
TARDBP	4	ELAVL1	0	affinity chromatography technology	Freibaum BD (2010)	1
ELAVL1	0	XPO4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
BHLHE40	5	ZHX1	1	two hybrid	Stelzl U (2005)	1