PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRPK2	1	EGLN2	4	enzymatic study	Varjosalo M (2013)	1
HIF1A	1	FBXW7	2	affinity chromatography technology	Cassavaugh JM (2011)	1
EGLN3	0	TRIP6	2	affinity chromatography technology	Rodriguez J (2016)	1
TRIM25	5	EGLN2	4	affinity chromatography technology	Choudhury NR (2017)	1
AJUBA	2	EGLN3	0	affinity chromatography technology	Foxler DE (2012)	1
TRIP6	2	LIMD1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	MAGEA11	1	affinity chromatography technology	Aprelikova O (2009)	1
EGLN2	4	SPOP	1	pull down, pull down	Zhang L (2017), Zhang L (2017)	2
LPP	2	EGLN2	4	affinity chromatography technology	Foxler DE (2012)	1
EGLN2	4	PRPF19	2	affinity chromatography technology	Sato M (2010)	1
SPRY2	4	HIF1A	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Hicks KC (2016), Hicks KC (2016), Hicks KC (2016)	3
SPRY2	4	SIAH2	0	pull down	Nadeau RJ (2007)	1
TRIP6	2	EGLN2	4	affinity chromatography technology	Foxler DE (2012)	1
EGLN2	4	CEP192	5	affinity chromatography technology	Moser SC (2013)	1
WTIP	2	EGLN3	0	affinity chromatography technology	Foxler DE (2012)	1
EGLN3	0	PRPF19	2	affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Sato M (2010), Sato M (2010), Sato M (2010), Sato M (2010)	4
AJUBA	2	EGLN2	4	affinity chromatography technology	Foxler DE (2012)	1
EGLN3	0	5430	0	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	SRPK2	1	affinity chromatography technology	Bennett EJ (2010)	1
FAM46A	2	EGLN2	4	two hybrid	Colland F (2004)	1
EGLN3	0	EGLN2	4	affinity chromatography technology, affinity chromatography technology	Nakayama K (2007), Nakayama K (2007)	2
EGLN2	4	MAGEA11	1	affinity chromatography technology	Aprelikova O (2009)	1
FBXW7	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
LIMD1	4	EGLN3	0	affinity chromatography technology, affinity chromatography technology	Foxler DE (2012), Rodriguez J (2016)	2
CUL3	17	PRPF19	2	affinity chromatography technology	Bennett EJ (2010)	1
LIMD1	4	EGLN2	4	affinity chromatography technology	Foxler DE (2012)	1
TRIM25	5	PRPF19	2	affinity chromatography technology	Choudhury NR (2017)	1
EPAS1	6	EGLN2	4	affinity chromatography technology, pull down	Steunou AL (2012), Barth S (2007)	2
A2M	8	EGLN2	4	two hybrid	Soler-Lopez M (2011)	1
EGLN3	0	SIAH2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Nakayama K (2007), Nakayama K (2004), Nakayama K (2004), Gopalsamy A (2014), Gopalsamy A (2014)	5
WTIP	2	EGLN2	4	affinity chromatography technology	Foxler DE (2012)	1
FBXW7	2	EGLN2	4	affinity chromatography technology	Takada M (2017)	1
5430	0	EGLN2	4	affinity chromatography technology	Mikhaylova O (2008)	1
TRIM25	5	DYRK1A	36	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SRPK2	1	affinity chromatography technology	Choudhury NR (2017)	1
HIF1A	1	EGLN2	4	pull down, pull down	Yoo YG (2008), Barth S (2007)	2
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
EGLN2	4	ATF4	2	two hybrid, affinity chromatography technology	Hiwatashi Y (2011), Hiwatashi Y (2011)	2
EGLN3	0	CEP192	5	affinity chromatography technology	Rodriguez J (2016)	1
HIF1A	1	EGLN3	0	pull down, pull down, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Baek JH (2005), Yoo YG (2008), Yeh IJ (2013), Rolland T (2014), Rantanen K (2013), Barth S (2007), Rodriguez J (2016), Rodriguez J (2016)	8
TRIP6	2	WTIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN2	4	DYRK1B	1	affinity chromatography technology	Lee SB (2016)	1
EGLN2	4	EGLN2	4	affinity chromatography technology	Nakayama K (2007)	1
EGLN2	4	CUL3	17	affinity chromatography technology	Zhang L (2017)	1
TRIP6	2	AJUBA	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EPAS1	6	HIF1A	1	affinity chromatography technology	Steunou AL (2012)	1
EGLN3	0	SPRY2	4	affinity chromatography technology	Anderson K (2011)	1
EGLN2	4	SIAH2	0	affinity chromatography technology, affinity chromatography technology	Nakayama K (2007), Nakayama K (2004)	2
5430	0	PRPF19	2	pull down	David CJ (2011)	1
EGLN3	0	EPAS1	6	two hybrid, affinity chromatography technology, pull down	Koeditz J (2007), Steunou AL (2012), Barth S (2007)	3
EGLN2	4	DYRK1A	36	affinity chromatography technology	Lee SB (2016)	1
EGLN3	0	DYRK1A	36	affinity chromatography technology	Rodriguez J (2016)	1
SPRY2	4	EGLN2	4	affinity chromatography technology, affinity chromatography technology	Anderson K (2011), Anderson K (2011)	2
TRIM25	5	EPAS1	6	affinity chromatography technology	Choudhury NR (2017)	1
SPOP	1	CUL3	17	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li C (2011), Cummings CM (2009), Choo YY (2011), Choo YY (2012), Plafker KS (2009), Kwon JE (2006), Kwon JE (2006), Wang J (2011), Wimuttisuk W (2014), Theurillat JP (2014), Sakaue T (2017)	11
EGLN3	0	ATF4	2	two hybrid, affinity chromatography technology, two hybrid	Koeditz J (2007), Koeditz J (2007), Hiwatashi Y (2011)	3