PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NINL	1	TP53BP2	5	bioid	Gupta GD (2015)	1
PPP1CA	3	TP53BP2	5	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Esteves SL (2012), Liu CY (2011), Colland F (2004), Huttlin EL (2015), Hauri S (2013), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	9
GOLGA2	2	CORO1A	0	two hybrid	Rolland T (2014)	1
GOLGA2	2	PARD6B	0	two hybrid	Rolland T (2014)	1
TIMM13	0	RASSF8	2	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	TBC1D24	1	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	PPP1R13B	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017)	3
KLC1	5	APP	1	pull down, affinity chromatography technology	Kamal A (2000), Muresan Z (2005)	2
PARD3	5	YWHAH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
RAB5C	2	APP	1	pull down	Olah J (2011)	1
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
CEP44	2	ANKRD28	1	bioid	Gupta GD (2015)	1
RASSF8	2	GOLPH3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RASSF8	2	TCOF1	1	affinity chromatography technology	Hein MY (2015)	1
CEP152	2	RASSF8	2	bioid	Gupta GD (2015)	1
AMOT	6	YAP1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang C (2012), Wang C (2012), Adler JJ (2013), Couzens AL (2013), Adler JJ (2013), Chan SW (2013), Dai X (2013), Hauri S (2013)	9
AMOT	6	RASSF8	2	bioid	Couzens AL (2013)	1
PPP1CC	2	RASSF8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017)	3
YWHAE	0	RAB11FIP1	2	affinity chromatography technology	Gloeckner CJ (2007)	1
YWHAH	0	RASSF8	2	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hein MY (2015)	2
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
PARD3	5	PRKCI	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Yang Z (2012)	5
AMOT	6	APP	1	pull down	Olah J (2011)	1
CORO1A	0	CEP44	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SFRP4	1	RASSF8	2	affinity chromatography technology	Huttlin EL (2015)	1
AMOT	6	TP53BP2	5	bioid	Couzens AL (2013)	1
YWHAH	0	PPP1CA	3	biochemical	Kristensen AR (2012)	1
YWHAG	5	YAP1	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Jin J (2004), Couzens AL (2013), Hauri S (2013), Enzo E (2015), Ivanov AA (2017)	5
RASSF8	2	ZBTB2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP152	2	TP53BP2	5	bioid	Gupta GD (2015)	1
PPP1CA	3	YAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Enzo E (2015)	4
PARD6B	0	RASSF8	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015)	2
PARD6B	0	PPP1CA	3	affinity chromatography technology	Hein MY (2015)	1
APP	1	PARD6A	0	pull down	Virok DP (2011)	1
PARD3	5	PARD6A	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Suzuki A (2001), Yang Z (2012), Hein MY (2015)	5
FAAP100	1	APP	1	pull down	Olah J (2011)	1
RAB3IP	0	YWHAE	0	affinity chromatography technology	Boldt K (2016)	1
RASSF8	2	APP	1	pull down	Olah J (2011)	1
PARD6B	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Waaijers S (2013), Waaijers S (2013), Hayase J (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
PDK1	1	RASSF8	2	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	PARP10	4	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	PCM1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAH	0	PARD6A	0	affinity chromatography technology	Brajenovic M (2004)	1
YWHAH	0	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004)	2
PSMD4	1	APP	1	pull down	Olah J (2011)	1
NINL	1	PPP1R13B	9	bioid	Gupta GD (2015)	1
NIN	4	PCM1	5	bioid	Gupta GD (2015)	1
YAP1	0	YWHAH	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Enzo E (2015)	4
RASSF8	2	RAB11FIP1	2	affinity chromatography technology	Hein MY (2015)	1
KLC1	5	RAB11FIP1	2	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	FAAP100	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POC1A	3	CORO1A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAE	0	RASSF8	2	affinity chromatography technology	Gloeckner CJ (2007)	1
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
YWHAH	0	PARD6B	0	affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Hein MY (2015)	2
RASSF8	2	RAB3IP	0	affinity chromatography technology	Boldt K (2016)	1
PPP1CC	2	TP53BP2	5	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Esteves SL (2012), Fardilha M (2011), Wang J (2011), Rolland T (2014), Huttlin EL (2015), Hauri S (2013), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	10
NIN	4	TP53BP2	5	bioid	Gupta GD (2015)	1
YWHAE	0	TP53BP2	5	affinity chromatography technology	Gloeckner CJ (2007)	1
NIN	4	YWHAH	0	bioid	Gupta GD (2015)	1
PARD6B	0	TP53BP2	5	affinity chromatography technology	Hein MY (2015)	1
YWHAG	5	PARD3	5	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
RASSF8	2	APPBP2	3	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	PRKCI	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKCI	1	APP	1	pull down	Olah J (2011)	1
YAP1	0	RASSF8	2	bioid	Couzens AL (2013)	1
RASSF8	2	KDM1A	2	two hybrid	Weimann M (2013)	1
NLN	1	APP	1	pull down	Olah J (2011)	1
APP	1	FRMD6	1	affinity chromatography technology	Huttlin EL (2017)	1
PPP1CC	2	PPP1R13B	9	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Esteves SL (2012), Fardilha M (2011), Huttlin EL (2015), Hauri S (2013), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	8
APP	1	APPBP2	3	two hybrid, pull down, affinity chromatography technology	Zheng P (1998), Zheng P (1998), Briand S (2011)	3
CEP152	2	YWHAH	0	bioid	Gupta GD (2015)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
RASSF8	2	TP53BP2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hauri S (2013), Hauri S (2013), Hein MY (2015), Huttlin EL (2017)	5
RAB11FIP1	2	YWHAG	5	affinity chromatography technology	Huttlin EL (2017)	1
PPP1CA	3	PPP1R13B	9	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Esteves SL (2012), Colland F (2004), Huttlin EL (2015), Hauri S (2013), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	8
YAP1	0	PARD3	5	affinity chromatography technology	Couzens AL (2013)	1
PARD6B	0	PARD6A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Brajenovic M (2004), Hein MY (2015)	3
RASSF8	2	FRMD6	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
PARD6B	0	APP	1	pull down	Olah J (2011)	1
RASSF8	2	ZNF639	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53BP2	5	PARD3	5	affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Hauri S (2013), Gen Y (2017), Gen Y (2017), Gen Y (2017)	4
RASSF8	2	TRIB1	1	affinity chromatography technology	Hein MY (2015)	1
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
RASSF8	2	POC1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAH	0	TP53BP2	5	affinity chromatography technology	Hein MY (2015)	1
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
YWHAE	0	PRKCI	1	affinity chromatography technology	Gloeckner CJ (2007)	1
AMOT	6	PRKCI	1	bioid	Couzens AL (2013)	1
CEP152	2	PCM1	5	bioid	Gupta GD (2015)	1
YWHAE	0	KLC1	5	affinity chromatography technology	Gloeckner CJ (2007)	1
CEP44	2	TP53BP2	5	bioid	Gupta GD (2015)	1
NINL	1	RASSF8	2	bioid	Gupta GD (2015)	1
PARD6A	0	TP53BP2	5	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	CEP44	2	affinity chromatography technology	Huttlin EL (2017)	1
RASSF8	2	KLC1	5	affinity chromatography technology	Dodding MP (2011)	1
YAP1	0	YWHAE	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Enzo E (2015)	3
YWHAE	0	PARD3	5	affinity chromatography technology	Gloeckner CJ (2007)	1
YWHAG	5	KLC1	5	affinity chromatography technology	Ewing RM (2007)	1
FRMD6	1	YWHAH	0	affinity chromatography technology	Hauri S (2013)	1
RASSF8	2	POLR2H	0	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	PPP1CB	9	affinity chromatography technology	Hauri S (2013)	1
AMOT	6	NIN	4	affinity chromatography technology	Sowa ME (2009)	1
PCM1	5	TP53BP2	5	bioid	Gupta GD (2015)	1
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
PPP1CB	9	TP53BP2	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Rolland T (2014), Hauri S (2013), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	5
PARD6A	0	RASSF8	2	affinity chromatography technology	Hein MY (2015)	1
POC1A	3	CEP44	2	bioid	Gupta GD (2015)	1
PSMD4	1	RASSF8	2	two hybrid	Rual JF (2005)	1
PPP1CA	3	PARD3	5	affinity chromatography technology, affinity chromatography technology, bioid	Lv XB (2015), Yadav L (2017), Yadav L (2017)	3
RASSF8	2	CORO1A	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKCI	1	PARD6A	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Brajenovic M (2004), Suzuki A (2001), Suzuki A (2001), Suzuki A (2001), Lamark T (2003), Lamark T (2003), Lamark T (2003), Lamark T (2003), Erdogan E (2006), Rolland T (2014), Yu H (2011), Hein MY (2015)	13
NIN	4	RASSF8	2	bioid	Gupta GD (2015)	1
YWHAG	5	AMOT	6	affinity chromatography technology	Adler JJ (2013)	1
FRMD6	1	TP53BP2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RASSF8	2	SETD2	20	affinity chromatography technology	Hein MY (2015)	1
YWHAG	5	FRMD6	1	affinity chromatography technology, affinity chromatography technology	Jin J (2004), Hauri S (2013)	2
NINL	1	PPP1CA	3	bioid	Gupta GD (2015)	1
PPP1CA	3	RASSF8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Hauri S (2013), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	5
YWHAE	0	PCM1	5	pull down, affinity chromatography technology	Tollenaere MA (2015), Tollenaere MA (2015)	2
RASSF8	2	NLN	1	affinity chromatography technology	Hein MY (2015)	1
RASSF8	2	GOLGA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARD3	5	PARD6B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohjima M (2002), Brajenovic M (2004), Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
YAP1	0	TP53BP2	5	two hybrid, two hybrid, pull down, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology	Espanel X (2001), Espanel X (2001), Espanel X (2001), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Gao K (2015), Espanel X (1999), Espanel X (1999), Enzo E (2015)	10
PPP1R13B	9	PPP1CB	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Hauri S (2013), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	4
LYN	2	RASSF8	2	affinity chromatography technology	Zhu J (2013)	1
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
PARD3	5	AMOT	6	affinity chromatography technology	Wells CD (2006)	1
PARD3	5	RASSF8	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brajenovic M (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
ANKRD28	1	RASSF8	2	bioid	Couzens AL (2013)	1
YWHAG	5	RASSF8	2	affinity chromatography technology	Jin J (2004)	1
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3
RAB5C	2	RASSF8	2	affinity chromatography technology	Hein MY (2015)	1
KLC1	5	CEP44	2	affinity chromatography technology	Hein MY (2015)	1