PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FBXW11	2	RANBP2	9	affinity chromatography technology	Low TY (2014)	1
AKAP13	11	PRKD1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Carnegie GK (2004), Carnegie GK (2004), Carnegie GK (2004), Carnegie GK (2004)	4
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
PRKAR2B	1	PRKAR2A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
PRKACA	2	PRKAR2A	0	affinity chromatography technology, biochemical	Varjosalo M (2013), Wan C (2015)	2
BAK1	0	AKAP13	11	affinity chromatography technology	Ewing RM (2007)	1
AKAP13	11	PRKCA	7	affinity chromatography technology	Carnegie GK (2004)	1
AKAP13	11	GNA12	2	affinity chromatography technology	Dutt P (2004)	1
PRKACA	2	AKAP13	11	enzymatic study	Carnegie GK (2004)	1
EGLN3	0	AKAP13	11	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	THRA	2	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
AKAP13	11	ESR1	0	pull down, two hybrid	Rubino D (1998), Rubino D (1998)	2
ESR1	0	SRPK2	1	affinity chromatography technology	Tarallo R (2011)	1
HNRNPL	3	FBXW11	2	affinity chromatography technology	Fei T (2017)	1
CTNNAL1	3	AKAP13	11	affinity chromatography technology, two hybrid	Park B (2002), Park B (2002)	2
FBXW11	2	AKAP13	11	affinity chromatography technology	Low TY (2014)	1
APP	1	AKAP13	11	pull down	Virok DP (2011)	1
AKAP13	11	THRA	2	pull down	Rubino D (1998)	1
AKAP13	11	MTR	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LNX1	7	AKAP13	11	affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017)	2
TRIM25	5	AKAP13	11	affinity chromatography technology	Choudhury NR (2017)	1
PRKCA	7	PRKCH	2	affinity chromatography technology	Huttlin EL (2017)	1
YWHAB	1	YWHAG	5	affinity chromatography technology, biochemical	Couzens AL (2013), Wan C (2015)	2
EGLN3	0	RTKN	0	affinity chromatography technology	Rodriguez J (2016)	1
GNA12	2	APP	1	pull down	Olah J (2011)	1
SRPK2	1	AKAP13	11	enzymatic study	Lipp JJ (2015)	1
APP	1	UBB	4	protein complementation assay	Kajiwara Y (2010)	1
AKAP13	11	PPARA	1	pull down	Rubino D (1998)	1
TRIM25	5	PRKAR2B	1	affinity chromatography technology	Choudhury NR (2017)	1
PRKAR2A	0	AKAP13	11	unspecified method, pull down, pull down	Alto NM (2003), Carr DW (1992), Carnegie GK (2004)	3
PPARA	1	RXRB	0	affinity chromatography technology	Nickkho-Amiry M (2012)	1
EGLN3	0	RHOA	0	affinity chromatography technology	Rodriguez J (2016)	1
FBXW11	2	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1
AKAP13	11	UBB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
LNX1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FBXW11	2	APC	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014), Huttlin EL (2017)	3
TRIM25	5	SRPK2	1	affinity chromatography technology	Choudhury NR (2017)	1
AKAP13	11	GNAQ	1	affinity chromatography technology	Sagi SA (2001)	1
YWHAB	1	RTKN	0	affinity chromatography technology	Couzens AL (2013)	1
HNRNPL	3	PPARA	1	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	CTNNAL1	3	affinity chromatography technology	Choudhury NR (2017)	1
RTKN	0	AKAP13	11	pull down	Baisamy L (2009)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
MAP1LC3A	0	APP	1	pull down	Olah J (2011)	1
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
RANBP2	9	AKAP13	11	two hybrid	Bandyopadhyay S (2010)	1
EGLN3	0	APC	5	affinity chromatography technology	Rodriguez J (2016)	1
AKAP13	11	RHOA	0	affinity chromatography technology, affinity chromatography technology	Klussmann E (2001), Baisamy L (2009)	2
YWHAB	1	APP	1	pull down	Olah J (2011)	1
AKAP13	11	PRKCH	2	affinity chromatography technology, affinity chromatography technology	Carnegie GK (2004), Carnegie GK (2004)	2
TRIM25	5	GNAQ	1	affinity chromatography technology	Choudhury NR (2017)	1
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
FBXW11	2	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
YWHAG	5	AKAP13	11	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology	Jin J (2004), Jin J (2004), Jin J (2004), Jin J (2004)	4
SRPK2	1	APP	1	pull down	Olah J (2011)	1
LNX1	7	PRKCA	7	affinity chromatography technology	Wolting CD (2011)	1
RTKN	0	MAP1LC3A	0	pull down	Baisamy L (2009)	1
PRKAR2B	1	AKAP13	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGLN3	0	PRKAR2A	0	affinity chromatography technology	Rodriguez J (2016)	1
AKAP13	11	MAP1LC3A	0	two hybrid, pull down, affinity chromatography technology, pull down	Baisamy L (2009), Baisamy L (2009), Baisamy L (2009), Baisamy L (2009)	4
PRKACA	2	PRKAR2B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Hein MY (2015), Okunishi K (2011), Huttlin EL (2017)	5
FBXW11	2	APP	1	affinity chromatography technology	Low TY (2014)	1
FBXW11	2	PRKACA	2	two hybrid	Wallach T (2013)	1
HNRNPL	3	AKAP13	11	affinity chromatography technology	Fei T (2017)	1
EGLN3	0	RANBP2	9	affinity chromatography technology	Rodriguez J (2016)	1
AKAP13	11	RXRB	0	pull down	Rubino D (1998)	1
YWHAB	1	AKAP13	11	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
APC	5	RANBP2	9	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Murawala P (2009), Novellasdemunt L (2017)	3
SRPK2	1	YWHAB	1	enzymatic study, affinity chromatography technology	Varjosalo M (2013), Jang SW (2009)	2
HNRNPL	3	SRPK2	1	affinity chromatography technology	Fei T (2017)	1
RTKN	0	APP	1	pull down	Olah J (2011)	1
APC	5	TRIM25	5	two hybrid	Arroyo R (2015)	1
PRKCA	7	YWHAG	5	affinity chromatography technology	Autieri MV (1999)	1
APC	5	AKAP13	11	affinity chromatography technology	Hein MY (2015)	1
EGLN3	0	MTR	4	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	PRKD1	7	affinity chromatography technology	Fei T (2017)	1
RTKN	0	RHOA	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Genth H (2003), Swiercz JM (2009), Edlund S (2004), Baisamy L (2009), Jaffe AB (2004), Lee MG (2016), Lee MG (2016), Du X (2012), Brozzi F (2009)	9