PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POLI	5	UBB	4	two hybrid	Plosky BS (2006)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
RNF11	0	CALCOCO2	0	two hybrid	Colland F (2004)	1
TRAF6	0	TP53	0	enzymatic study, affinity chromatography technology	Zhang X (2016), Zhang X (2016)	2
DVL2	5	POLI	5	two hybrid	Rual JF (2005)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
RNF11	0	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
CALCOCO2	0	POLI	5	two hybrid	Rual JF (2005)	1
POLI	5	REV1	1	two hybrid, two hybrid, pull down	Ohashi E (2004), Ohashi E (2009), Ohashi E (2009)	3
PCNA	0	REV1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Pozo FM (2011), Pozo FM (2011), Qin Z (2013), Shim HS (2015)	4
UBC	7	CALCOCO2	0	pull down, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique	Fenner BJ (2009), Fenner BJ (2009), Rolland T (2014), Tumbarello DA (2015), Xie X (2015), Xie X (2015), Xie X (2015), Xie X (2015), Ordureau A (2015), Minowa-Nozawa A (2017)	10
TRIM39	0	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang L (2012), Zhang L (2012), Zhang L (2012)	3
TP53	0	POLI	5	affinity chromatography technology, imaging technique	Hampp S (2016), Hampp S (2016)	2
POLI	5	UBC	7	two hybrid, two hybrid, far western blotting, x-ray crystallography, pull down, far western blotting	Plosky BS (2006), Plosky BS (2006), McIntyre J (2012), Bomar MG (2010), Plosky BS (2006), McIntyre J (2012)	6
7515	0	TP53	0	affinity chromatography technology	Gueven N (2004)	1
APP	1	UBB	4	protein complementation assay	Kajiwara Y (2010)	1
POLI	5	TRIM39	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
POLI	5	TRIM23	3	two hybrid	Venkatesan K (2009)	1
RNF11	0	APP	1	pull down	Olah J (2011)	1
RNF11	0	POLI	5	two hybrid	Colland F (2004)	1
POLI	5	TMEM239	0	two hybrid	Rolland T (2014)	1
TRIM23	3	UBC	7	enzymatic study	Dawidziak DM (2017)	1
CALCOCO2	0	TRAF6	0	two hybrid	Wang J (2011)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
UBB	4	CALCOCO2	0	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
TRIM39	0	UBC	7	enzymatic study	Woodsmith J (2012)	1
UBB	4	DAZAP2	1	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
PCNA	0	7515	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, fluorescent resonance energy transfe, affinity chromatography technology	Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Ogi T (2010)	6
POLI	5	ZBTB44	0	two hybrid	Rolland T (2014)	1
TP53	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Banks D (2006), Banks D (2006), Hampp S (2016), Hampp S (2016)	4
UBC	7	DAZAP2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
REV1	1	TP53	0	affinity chromatography technology	Shim HS (2015)	1
DVL2	5	TP53	0	two hybrid, two hybrid	Rual JF (2005), Lim J (2006)	2
UBC	7	POLH	1	pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Bienko M (2005), Plosky BS (2006), Sekimoto T (2010), Bienko M (2005), Plosky BS (2006), Ahmed-Seghir S (2015)	6
POLI	5	APP	1	pull down	Olah J (2011)	1
POLH	1	PCNA	0	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology	Haracska L (2001), Haracska L (2001), Kannouche PL (2004), Bienko M (2010), Bienko M (2010), Bienko M (2010), Bienko M (2010), Jung YS (2011), Zlatanou A (2011), Plosky BS (2006), Vidal AE (2004), Sekimoto T (2010), Hibbert RG (2012), Mosbech A (2012), Durando M (2013), Qin Z (2013), Fu D (2013), Fu D (2013), Sekimoto T (2010), Sekimoto T (2010), Sekimoto T (2010), Ahmed-Seghir S (2015), Inoue A (2014), Hedglin M (2016), Hedglin M (2016), Dai X (2016), Guan J (2017)	27
TP53	0	UBB	4	affinity chromatography technology	Fogeron ML (2013)	1
UBC	7	REV1	1	pull down	Pozo FM (2011)	1
TRAF6	0	POLI	5	two hybrid	Rolland T (2014)	1
DAZAP2	1	POLI	5	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
POLH	1	APP	1	pull down	Olah J (2011)	1
TRIM39	0	APP	1	pull down	Olah J (2011)	1
POLI	5	POLH	1	two hybrid, far western blotting, two hybrid, far western blotting, affinity chromatography technology	Kannouche P (2003), Kannouche P (2003), McIntyre J (2012), McIntyre J (2012), McIntyre J (2012)	5
POLI	5	7515	0	affinity chromatography technology, affinity chromatography technology	Petta TB (2008), Petta TB (2008)	2
DAZAP2	1	CALCOCO2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RNF11	0	UBC	7	two hybrid, two hybrid	Li H (2004), Colland F (2004)	2
POLH	1	REV1	1	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, pull down, two hybrid, pull down, pull down	Yuasa MS (2006), Yuasa MS (2006), Pozo FM (2011), Ohashi E (2004), Ohashi E (2004), Pozhidaeva A (2012), Pozhidaeva A (2012), Tissier A (2004), Tissier A (2004), Ohashi E (2009), Ohashi E (2009), Pustovalova Y (2012)	12
POLI	5	PCNA	0	two hybrid, x-ray crystallography, two hybrid, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, pull down	Plosky BS (2006), Hishiki A (2008), Vidal AE (2004), Vidal AE (2004), Haracska L (2001), McIntyre J (2012), McIntyre J (2012), Boehm EM (2016)	8
MTNR1B	1	POLI	5	two hybrid	Benleulmi-Chaachoua A (2016)	1