PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SDHA	2	PDHA1	7	biochemical, affinity chromatography technology	Havugimana PC (2012), Malty RH (2017)	2
LAT	0	MAP4K1	1	affinity chromatography technology, biochemical	Ling P (2001), Ling P (2001)	2
GRB2	2	HSP90AA1	7	affinity chromatography technology	Brehme M (2009)	1
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
BLNK	2	MAP4K1	1	pull down, affinity chromatography technology	Tsuji S (2001), Tsuji S (2001)	2
EGFR	5	CRKL	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
FBXW8	2	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Huber C (2005), Huber C (2005), Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Skaar JR (2007), Skaar JR (2007), Tsutsumi T (2008), Kong C (2012), Xu X (2012), Xu X (2008), Xu X (2008)	13
COPS5	0	SDHA	2	affinity chromatography technology	Bennett EJ (2010)	1
MAP4K1	1	EGFR	5	biochemical, two hybrid, protein complementation assay	Anafi M (1997), Kotlyar M (2015), Petschnigg J (2014)	3
SPRY1	2	GRB2	2	affinity chromatography technology	Lao DH (2006)	1
FBXW7	2	RBX1	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017)	4
MAP4K1	1	MAP3K11	7	enzymatic study	Leung IW (2001)	1
BLNK	2	NCK1	0	affinity chromatography technology, imaging technique	Fu C (1998), Chen TC (2014)	2
CUL7	4	HSD17B10	1	affinity chromatography technology	Hanson D (2014)	1
MAP3K7	2	HSP90AA1	7	affinity chromatography technology	Liu XY (2008)	1
HSP90AA1	7	MAP4K1	1	affinity chromatography technology	Taipale M (2012)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
GRB2	2	HCLS1	0	pull down	Takemoto Y (1998)	1
MAP4K1	1	HIST1H2AB	0	enzymatic study	Sawasdikosol S (2007)	1
PDHA1	7	HIST1H2AB	0	affinity chromatography technology	Malty RH (2017)	1
LAT	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Paz PE (2001), Zhang W (1998), Perez-Villar JJ (2002), Motto DG (1994), Houtman JC (2006)	5
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
MAP3K7	2	RBX1	2	two hybrid	Vinayagam A (2011)	1
CARD11	4	COPS5	0	affinity chromatography technology, affinity chromatography technology	Welteke V (2009), Welteke V (2009)	2
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
MAP4K1	1	NCK1	0	two hybrid, pull down, affinity chromatography technology, unspecified method	Anafi M (1997), Ling P (1999), Ling P (2001), Liu BA (2012)	4
MAP4K1	1	FBXW7	2	affinity chromatography technology	Wang H (2014)	1
SOD1	0	MAP4K1	1	affinity chromatography technology	Malty RH (2017)	1
SOD1	0	HIST1H2AB	0	affinity chromatography technology	Malty RH (2017)	1
COPS5	0	HSD17B10	1	affinity chromatography technology	Bennett EJ (2010)	1
HSD17B10	1	MAP4K1	1	affinity chromatography technology	Malty RH (2017)	1
CARD11	4	MAP4K1	1	affinity chromatography technology, enzymatic study	Brenner D (2009), Brenner D (2009)	2
PPP4C	0	MAP4K1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhou G (2004), Zhou G (2004), Zhou G (2004), Wang H (2014)	4
LRRK1	12	MAP4K1	1	affinity chromatography technology	Titz B (2010)	1
MAP3K7	2	CARD11	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016)	4
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
GRAP2	0	BLNK	2	pull down, unspecified method, affinity chromatography technology	Berry DM (2002), Berry DM (2002), Yankee TM (2003)	3
CRK	0	MAP4K1	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Oehrl W (1998), Ling P (1999), Ling P (1999), Ling P (2001)	4
FBXW8	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Litterman N (2011), Busino L (2012), Watanabe N (2004), Ponyeam W (2012), Tian X (2015), Xu X (2008), Hauri S (2016)	9
CRKL	1	MAP4K1	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Oehrl W (1998), Ling P (1999), Ling P (1999), Ling P (2001)	4
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
MAP3K7	2	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
CUL7	4	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Arai T (2003), Arai T (2003)	2
EGFR	5	GRAP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
MAP4K1	1	MAP3K7	2	affinity chromatography technology	Zhou G (1999)	1
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
MAP3K11	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2004), Zhang H (2004), Blessing NA (2014)	3
CUL7	4	CRKL	1	affinity chromatography technology	Hanson D (2014)	1
LRRK1	12	GRB2	2	affinity chromatography technology, affinity chromatography technology	Titz B (2010), Brehme M (2009)	2
MAP4K1	1	TMEM101	0	two hybrid	Wang J (2011)	1
PDHA1	7	MAP4K1	1	affinity chromatography technology	Malty RH (2017)	1
HCLS1	0	MAP4K1	1	affinity chromatography technology	Nagata Y (1999)	1
EGFR	5	HSD17B10	1	affinity chromatography technology	Tong J (2014)	1
SDHA	2	HSD17B10	1	affinity chromatography technology	Malty RH (2017)	1
EGFR	5	LRRK1	12	affinity chromatography technology	Yao Z (2017)	1
COPS5	0	HIST1H2AB	0	affinity chromatography technology	Bennett EJ (2010)	1
SPRY1	2	LAT	0	affinity chromatography technology, affinity chromatography technology	Lee JS (2009), Lee JS (2009)	2
MAP4K1	1	FBXW8	2	affinity chromatography technology, affinity chromatography technology	Wang H (2014), Wang H (2014)	2
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	LAT	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
MAP4K1	1	MAP4K1	1	enzymatic study, affinity chromatography technology, enzymatic study	Wang H (2014), Wang H (2014), Brenner D (2009)	3
COPS5	0	MAP4K1	1	affinity chromatography technology	Bennett EJ (2010)	1
CRKL	1	BLNK	2	affinity chromatography technology	Engels N (2001)	1
NCK1	0	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	6
FBXW8	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Xu X (2008)	3
GRAP2	0	LAT	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Liu SK (1999), Liu SK (1999), Liu SK (1999), Asada H (1999)	4
MAP3K11	7	COPS5	0	two hybrid	Bandyopadhyay S (2010)	1
MAP4K1	1	SPRY1	2	affinity chromatography technology	Lee JS (2009)	1
GRAP2	0	MAP4K1	1	affinity chromatography technology, pull down, two hybrid, genetic interference, biochemical, affinity chromatography technology	Ma W (2001), Ma W (2001), Ma W (2001), Ma W (2001), Yankee TM (2003), Yankee TM (2003)	6
FBXW8	2	HSP90AA1	7	affinity chromatography technology	Ponyeam W (2012)	1
DBNL	2	MAP4K1	1	pull down, affinity chromatography technology	Ensenat D (1999), Ensenat D (1999)	2
SDHA	2	HIST1H2AB	0	affinity chromatography technology	Malty RH (2017)	1
SDHA	2	MAP4K1	1	affinity chromatography technology	Malty RH (2017)	1
GRB2	2	MAP4K1	1	pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Oehrl W (1998), Anafi M (1997), Anafi M (1997), Anafi M (1997), Ling P (1999), Ling P (2001)	6
SKP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017)	28
RBX1	2	CUL7	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Dias DC (2002), Dias DC (2002), Andrews P (2006), Andrews P (2006), Huber C (2005), Huber C (2005), Xu X (2012), Nie J (2015)	9
CUL7	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Tsutsumi T (2008), Xu X (2012), Hauri S (2016)	4
MAP4K1	1	RBX1	2	affinity chromatography technology	Wang H (2014)	1
HSD17B10	1	PDHA1	7	two hybrid	Narayan SB (2012)	1
MAP4K1	1	CUL7	4	affinity chromatography technology	Wang H (2014)	1
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
BLNK	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fu C (1998), Engels N (2001), Fusaki N (2000), Wienands J (1998), Oellerich T (2011), Oellerich T (2011)	6
HSD17B10	1	HIST1H2AB	0	affinity chromatography technology	Malty RH (2017)	1
GRB2	2	CRKL	1	affinity chromatography technology	Park RK (1999)	1
MAP4K1	1	SKP1	0	affinity chromatography technology	Wang H (2014)	1