PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
SDHA 2 PDHA1 7 biochemical, affinity chromatography technology Havugimana PC (2012), Malty RH (2017) 2
LAT 0 MAP4K1 1 affinity chromatography technology, biochemical Ling P (2001), Ling P (2001) 2
GRB2 2 HSP90AA1 7 affinity chromatography technology Brehme M (2009) 1
HSP90AA1 7 SKP1 0 pull down Zhang M (2008) 1
BLNK 2 MAP4K1 1 pull down, affinity chromatography technology Tsuji S (2001), Tsuji S (2001) 2
EGFR 5 CRKL 1 affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014) 4
FBXW8 2 CUL7 4 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Dias DC (2002), Huber C (2005), Huber C (2005), Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Skaar JR (2007), Skaar JR (2007), Tsutsumi T (2008), Kong C (2012), Xu X (2012), Xu X (2008), Xu X (2008) 13
COPS5 0 SDHA 2 affinity chromatography technology Bennett EJ (2010) 1
MAP4K1 1 EGFR 5 biochemical, two hybrid, protein complementation assay Anafi M (1997), Kotlyar M (2015), Petschnigg J (2014) 3
SPRY1 2 GRB2 2 affinity chromatography technology Lao DH (2006) 1
FBXW7 2 RBX1 2 biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017) 4
MAP4K1 1 MAP3K11 7 enzymatic study Leung IW (2001) 1
BLNK 2 NCK1 0 affinity chromatography technology, imaging technique Fu C (1998), Chen TC (2014) 2
CUL7 4 HSD17B10 1 affinity chromatography technology Hanson D (2014) 1
MAP3K7 2 HSP90AA1 7 affinity chromatography technology Liu XY (2008) 1
HSP90AA1 7 MAP4K1 1 affinity chromatography technology Taipale M (2012) 1
EGFR 5 GRB2 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009) 51
GRB2 2 HCLS1 0 pull down Takemoto Y (1998) 1
MAP4K1 1 HIST1H2AB 0 enzymatic study Sawasdikosol S (2007) 1
PDHA1 7 HIST1H2AB 0 affinity chromatography technology Malty RH (2017) 1
LAT 0 GRB2 2 affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down Paz PE (2001), Zhang W (1998), Perez-Villar JJ (2002), Motto DG (1994), Houtman JC (2006) 5
SKP1 0 RBX1 2 affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016) 11
MAP3K7 2 RBX1 2 two hybrid Vinayagam A (2011) 1
CARD11 4 COPS5 0 affinity chromatography technology, affinity chromatography technology Welteke V (2009), Welteke V (2009) 2
EGFR 5 HSP90AA1 7 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014) 8
MAP4K1 1 NCK1 0 two hybrid, pull down, affinity chromatography technology, unspecified method Anafi M (1997), Ling P (1999), Ling P (2001), Liu BA (2012) 4
MAP4K1 1 FBXW7 2 affinity chromatography technology Wang H (2014) 1
SOD1 0 MAP4K1 1 affinity chromatography technology Malty RH (2017) 1
SOD1 0 HIST1H2AB 0 affinity chromatography technology Malty RH (2017) 1
COPS5 0 HSD17B10 1 affinity chromatography technology Bennett EJ (2010) 1
HSD17B10 1 MAP4K1 1 affinity chromatography technology Malty RH (2017) 1
CARD11 4 MAP4K1 1 affinity chromatography technology, enzymatic study Brenner D (2009), Brenner D (2009) 2
PPP4C 0 MAP4K1 1 affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology Zhou G (2004), Zhou G (2004), Zhou G (2004), Wang H (2014) 4
LRRK1 12 MAP4K1 1 affinity chromatography technology Titz B (2010) 1
MAP3K7 2 CARD11 4 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Srivastava R (2010), McCully RR (2008), Shinohara H (2016), Shinohara H (2016) 4
NCK1 0 GRB2 2 affinity chromatography technology, affinity chromatography technology de Castro RO (2012), de Castro RO (2012) 2
GRAP2 0 BLNK 2 pull down, unspecified method, affinity chromatography technology Berry DM (2002), Berry DM (2002), Yankee TM (2003) 3
CRK 0 MAP4K1 1 pull down, pull down, affinity chromatography technology, affinity chromatography technology Oehrl W (1998), Ling P (1999), Ling P (1999), Ling P (2001) 4
FBXW8 2 SKP1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Dias DC (2002), Okabe H (2007), Litterman N (2011), Busino L (2012), Watanabe N (2004), Ponyeam W (2012), Tian X (2015), Xu X (2008), Hauri S (2016) 9
CRKL 1 MAP4K1 1 pull down, pull down, affinity chromatography technology, affinity chromatography technology Oehrl W (1998), Ling P (1999), Ling P (1999), Ling P (2001) 4
CRK 0 GRB2 2 pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009) 6
MAP3K7 2 COPS5 0 two hybrid Bandyopadhyay S (2010) 1
CUL7 4 FBXW7 2 affinity chromatography technology, affinity chromatography technology Arai T (2003), Arai T (2003) 2
EGFR 5 GRAP2 0 two hybrid, protein complementation assay, affinity chromatography technology Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014) 3
MAP4K1 1 MAP3K7 2 affinity chromatography technology Zhou G (1999) 1
COPS5 0 SKP1 0 affinity chromatography technology Bennett EJ (2010) 1
EGFR 5 CRK 0 affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014) 9
HSP90AA1 7 FBXW7 2 affinity chromatography technology Taipale M (2012) 1
MAP3K11 7 HSP90AA1 7 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Zhang H (2004), Zhang H (2004), Blessing NA (2014) 3
CUL7 4 CRKL 1 affinity chromatography technology Hanson D (2014) 1
LRRK1 12 GRB2 2 affinity chromatography technology, affinity chromatography technology Titz B (2010), Brehme M (2009) 2
MAP4K1 1 TMEM101 0 two hybrid Wang J (2011) 1
PDHA1 7 MAP4K1 1 affinity chromatography technology Malty RH (2017) 1
HCLS1 0 MAP4K1 1 affinity chromatography technology Nagata Y (1999) 1
EGFR 5 HSD17B10 1 affinity chromatography technology Tong J (2014) 1
SDHA 2 HSD17B10 1 affinity chromatography technology Malty RH (2017) 1
EGFR 5 LRRK1 12 affinity chromatography technology Yao Z (2017) 1
COPS5 0 HIST1H2AB 0 affinity chromatography technology Bennett EJ (2010) 1
SPRY1 2 LAT 0 affinity chromatography technology, affinity chromatography technology Lee JS (2009), Lee JS (2009) 2
MAP4K1 1 FBXW8 2 affinity chromatography technology, affinity chromatography technology Wang H (2014), Wang H (2014) 2
COPS5 0 HSP90AA1 7 affinity chromatography technology Bennett EJ (2010) 1
EGFR 5 LAT 0 two hybrid, protein complementation assay, affinity chromatography technology Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014) 3
MAP4K1 1 MAP4K1 1 enzymatic study, affinity chromatography technology, enzymatic study Wang H (2014), Wang H (2014), Brenner D (2009) 3
COPS5 0 MAP4K1 1 affinity chromatography technology Bennett EJ (2010) 1
CRKL 1 BLNK 2 affinity chromatography technology Engels N (2001) 1
NCK1 0 EGFR 5 pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014) 6
FBXW8 2 RBX1 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Dias DC (2002), Okabe H (2007), Xu X (2008) 3
GRAP2 0 LAT 0 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology Liu SK (1999), Liu SK (1999), Liu SK (1999), Asada H (1999) 4
MAP3K11 7 COPS5 0 two hybrid Bandyopadhyay S (2010) 1
MAP4K1 1 SPRY1 2 affinity chromatography technology Lee JS (2009) 1
GRAP2 0 MAP4K1 1 affinity chromatography technology, pull down, two hybrid, genetic interference, biochemical, affinity chromatography technology Ma W (2001), Ma W (2001), Ma W (2001), Ma W (2001), Yankee TM (2003), Yankee TM (2003) 6
FBXW8 2 HSP90AA1 7 affinity chromatography technology Ponyeam W (2012) 1
DBNL 2 MAP4K1 1 pull down, affinity chromatography technology Ensenat D (1999), Ensenat D (1999) 2
SDHA 2 HIST1H2AB 0 affinity chromatography technology Malty RH (2017) 1
SDHA 2 MAP4K1 1 affinity chromatography technology Malty RH (2017) 1
GRB2 2 MAP4K1 1 pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology Oehrl W (1998), Anafi M (1997), Anafi M (1997), Anafi M (1997), Ling P (1999), Ling P (2001) 6
SKP1 0 FBXW7 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017) 28
RBX1 2 CUL7 4 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Dias DC (2002), Dias DC (2002), Dias DC (2002), Andrews P (2006), Andrews P (2006), Huber C (2005), Huber C (2005), Xu X (2012), Nie J (2015) 9
CUL7 4 SKP1 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Dias DC (2002), Tsutsumi T (2008), Xu X (2012), Hauri S (2016) 4
MAP4K1 1 RBX1 2 affinity chromatography technology Wang H (2014) 1
HSD17B10 1 PDHA1 7 two hybrid Narayan SB (2012) 1
MAP4K1 1 CUL7 4 affinity chromatography technology Wang H (2014) 1
COPS5 0 RBX1 2 affinity chromatography technology Olma MH (2009) 1
BLNK 2 GRB2 2 affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology Fu C (1998), Engels N (2001), Fusaki N (2000), Wienands J (1998), Oellerich T (2011), Oellerich T (2011) 6
HSD17B10 1 HIST1H2AB 0 affinity chromatography technology Malty RH (2017) 1
GRB2 2 CRKL 1 affinity chromatography technology Park RK (1999) 1
MAP4K1 1 SKP1 0 affinity chromatography technology Wang H (2014) 1