PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DMC1	2	RFWD2	0	affinity chromatography technology	Huttlin EL (2015)	1
TRIM23	3	DMC1	2	two hybrid	Rolland T (2014)	1
DMC1	2	RAD51	3	two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Masson JY (1999), Masson JY (1999), Masson JY (1999), Thorslund T (2007), Huttlin EL (2015), Huttlin EL (2017)	6
SIRT3	1	DMC1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA2	6	RAD51	3	two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Sharan SK (1997), Lin HR (2003), Yu DS (2003), Yu DS (2003), Chen PL (1998), Chen PL (1998), Chen PL (1998), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sarkisian CJ (2001), Wong AK (1997), Wong AK (1997), Katagiri T (1998), Katagiri T (1998), Pellegrini L (2002), Tarsounas M (2004), Liu J (2001), Chen J (1998), Sharan SK (1997), Marmorstein LY (1998), Ohashi A (2005), Shivji MK (2006), Xia B (2006), Xia B (2006), Badie S (2010), Liu J (2010), Carreira A (2011), Chen CF (1999), Chen CF (1999), Chen CF (1999), Lee M (2011), Esashi F (2005), Esashi F (2005), Esashi F (2005), Thorslund T (2007), Thorslund T (2007), Esashi F (2007), Brough R (2012), Zhao W (2015), Chu WK (2015), Trego KS (2016), Trego KS (2016), Trego KS (2016), Trego KS (2016), Luo K (2016)	46
DMC1	2	SVIP	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DMC1	2	POTEF	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMA3	1	GORASP2	1	two hybrid	Rolland T (2014)	1
DMC1	2	DNAJA3	2	imaging technique	Shinohara M (2000)	1
NIF3L1	0	KCTD17	0	two hybrid	Rual JF (2005)	1
RAD51	3	DNAJA3	2	imaging technique	Shinohara M (2000)	1
BRCA2	6	DMC1	2	affinity chromatography technology, pull down, two hybrid, unspecified method	Thorslund T (2007), Thorslund T (2007), Thorslund T (2007), Thorslund T (2007)	4
DMC1	2	NIF3L1	0	two hybrid	Rolland T (2014)	1
DMC1	2	DMC1	2	two hybrid	Rolland T (2014)	1
DMC1	2	GORASP2	1	two hybrid	Rolland T (2014)	1
SDCBP	0	DMC1	2	two hybrid	Rolland T (2014)	1
PSMA3	1	DMC1	2	two hybrid	Rolland T (2014)	1
ZNF302	0	DMC1	2	affinity chromatography technology	Huttlin EL (2017)	1
DMC1	2	KCTD17	0	two hybrid	Rolland T (2014)	1
DMC1	2	ACTA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2