PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TK1	0	CDKN1A	1	affinity chromatography technology, pull down	Huang DY (2001), Huang DY (2001)	2
PTEN	24	PKN2	6	affinity chromatography technology	Crockett DK (2005)	1
RAP1B	0	CHGB	3	two hybrid	Vinayagam A (2011)	1
MARK3	2	CHGB	3	two hybrid	Stelzl U (2005)	1
UBQLN1	1	APP	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Stieren ES (2011), Stieren ES (2011), Hiltunen M (2006)	3
TWF2	2	CHGB	3	two hybrid	Stelzl U (2005)	1
UBQLN1	1	CHGB	3	two hybrid	Stieren ES (2011)	1
RAP1B	0	APP	1	pull down	Olah J (2011)	1
S100A8	0	CHGB	3	two hybrid	Stelzl U (2005)	1
CHGB	3	APP	1	pull down	Olah J (2011)	1
FGFR3	7	CHGB	3	two hybrid	Stelzl U (2005)	1
TK1	0	TUBB2A	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ATXN2	3	CHGB	3	two hybrid	Stelzl U (2005)	1
PTEN	24	S100A8	0	pull down	Verrastro I (2015)	1
MGLL	3	CHGB	3	two hybrid	Stelzl U (2005)	1
PRKN	1	ATXN2	3	affinity chromatography technology	Huynh DP (2007)	1
RCC1	2	CHGB	3	two hybrid	Vinayagam A (2011)	1
S100A8	0	APP	1	pull down	Olah J (2011)	1
PRAG1	10	CHGB	3	two hybrid	Stelzl U (2005)	1
PTEN	24	CHGB	3	two hybrid	Stelzl U (2005)	1
CDKN1A	1	S100A8	0	two hybrid	Vinayagam A (2011)	1
ACACA	5	CHGB	3	two hybrid	Stelzl U (2005)	1
FGFR3	7	SLC25A6	3	two hybrid	Stelzl U (2005)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
CDKN1A	1	MOGS	3	affinity chromatography technology	Fogeron ML (2013)	1
PTEN	24	ACACA	5	affinity chromatography technology	Maddika S (2011)	1
PTEN	24	TUBB2A	2	affinity chromatography technology	Maddika S (2011)	1
SLC25A6	3	CHGB	3	two hybrid	Stelzl U (2005)	1
RAC2	0	CHGB	3	two hybrid	Vinayagam A (2011)	1
TAZ	1	CHGB	3	two hybrid	Stelzl U (2005)	1
SAFB2	3	CHGB	3	two hybrid	Stelzl U (2005)	1
CBFB	1	CHGB	3	two hybrid	Stelzl U (2005)	1
YLPM1	6	CHGB	3	two hybrid	Stelzl U (2005)	1
MOGS	3	RAP1B	0	biochemical	Havugimana PC (2012)	1
PTEN	24	SLC25A6	3	genetic interference	Vizeacoumar FJ (2013)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
CDKN1A	1	CHGB	3	two hybrid	Vinayagam A (2011)	1
POLD1	5	CHGB	3	two hybrid	Stelzl U (2005)	1
TUBB2A	2	CHGB	3	two hybrid	Stelzl U (2005)	1
PRKN	1	CHGB	3	affinity chromatography technology	Zanon A (2013)	1
CCDC92	1	CHGB	3	two hybrid	Stelzl U (2005)	1
MOGS	3	CHGB	3	two hybrid	Stelzl U (2005)	1
TWF2	2	TUBB2A	2	biochemical	Kristensen AR (2012)	1
TK1	0	APP	1	pull down	Olah J (2011)	1
TK1	0	CHGB	3	two hybrid	Vinayagam A (2011)	1
OGG1	0	CHGB	3	two hybrid	Stelzl U (2005)	1
ANXA7	0	CHGB	3	two hybrid	Vinayagam A (2011)	1
PKN2	6	CHGB	3	two hybrid	Vinayagam A (2011)	1