PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHGA	4	SGF29	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
CHGA	4	SAPCD2	0	affinity chromatography technology	Huttlin EL (2017)	1
CHGA	4	DENR	2	affinity chromatography technology	Huttlin EL (2017)	1
PFDN1	0	CHGA	4	two hybrid	Vinayagam A (2011)	1
PRKN	1	NEK2	2	affinity chromatography technology, enzymatic study	Lee SB (2015), Lee SB (2015)	2
UBC	7	CHGA	4	pull down	Nathan JA (2013)	1
NEK2	2	CHGA	4	two hybrid	Vinayagam A (2011)	1
PRKN	1	CHGA	4	affinity chromatography technology	Zanon A (2013)	1
NTRK1	1	CHGA	4	affinity chromatography technology	Emdal KB (2015)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
PLG	3	CHGA	4	enzymatic study	Jiang Q (2001)	1
CDC37	0	CHGA	4	two hybrid	Vinayagam A (2011)	1
NTRK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2