PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF6	0	TAX1BP1	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Ling L (2000), Ling L (2000), Ling L (2000), Wang J (2011)	4
SPAG5	1	FBXO28	2	two hybrid	Rolland T (2014)	1
EMILIN1	1	ODF2L	4	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	ZMYM6	5	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
EMILIN1	1	TAB2	5	affinity chromatography technology	Huttlin EL (2017)	1
CDC27	2	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Hein MY (2015), Qiao R (2016), Qiao R (2016), Boldt K (2016)	18
EMILIN1	1	DYNC1I1	1	pull down	Ban KH (2007)	1
TRAF6	0	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takaesu G (2000), Ninomiya-Tsuji J (1999), Walsh MC (2008)	3
EMILIN1	1	BEX5	0	two hybrid	Rolland T (2014)	1
EMILIN1	1	TAB1	1	affinity chromatography technology	Huttlin EL (2017)	1
TAB2	5	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Li S (2011), Li S (2011), Mendoza H (2008), Shin MS (2009), Suzuki S (2007), Jiang Z (2002), Wang J (2011), Xia ZP (2009), Charlaftis N (2014), St-Denis N (2016)	14
DYNC1I1	1	WDCP	2	two hybrid	Vinayagam A (2011)	1
ARRB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006), Xiao N (2015)	3
EMILIN1	1	NUMA1	10	affinity chromatography technology, biochemical, pull down, imaging technique, imaging technique	Ban KH (2007), Ban KH (2007), Ban KH (2007), Ban KH (2007), Ban KH (2007)	5
EMILIN1	1	IFT20	0	two hybrid	Rolland T (2014)	1
EMILIN1	1	NFRKB	4	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	RPUSD3	1	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	PDLIM5	0	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	PLAC9	0	two hybrid	Rolland T (2014)	1
EMILIN1	1	CDC23	3	affinity chromatography technology	Ban KH (2007)	1
MIA2	5	EMILIN1	1	two hybrid	Rolland T (2014)	1
EMILIN1	1	NUP214	3	affinity chromatography technology	Huttlin EL (2017)	1
ARRB2	5	TAB1	1	affinity chromatography technology	Xiao K (2007)	1
EMILIN1	1	FDXR	1	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	WDCP	2	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	MAP3K7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Ishitani T (2003), Takaesu G (2000), Ninomiya-Tsuji J (1999), Takaesu G (2001), Mochida Y (2000), Mochida Y (2000), Walsh MC (2008), Sorrentino A (2008), Frobose H (2006), Ishitani T (2003), Xia ZP (2009), Jiang Z (2003), Jiang Z (2003), Yamazaki K (2009), Yamazaki K (2009), Jiang Z (2002), Jiang Z (2002), Cui W (2012), Jiang Z (2003), Minoda Y (2009), Gao D (2009), Lee HJ (2012), Hirata Y (2006), Hu MM (2014), Fujikawa H (2013), Sun D (2011), Li W (2015), Lin J (2015), Lee Y (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016), Ji YX (2016)	33
EMILIN1	1	CCDC18	2	affinity chromatography technology	Huttlin EL (2017)	1
CEP170	4	SPAG5	1	affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Huttlin EL (2017)	3
EMILIN1	1	RDH13	0	affinity chromatography technology	Huttlin EL (2017)	1
TAB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Takaesu G (2000), Takaesu G (2000), Takaesu G (2001), Takaesu G (2001), Walsh MC (2008), Ma Q (2008), Windheim M (2008), Xia ZP (2009), Jiang Z (2003), Kanayama A (2004), Kanayama A (2004), Yokota S (2008), Jiang Z (2002), Jiang Z (2002), Jiang Z (2003), Wang J (2011), Yong Kim S (2013), Jeon J (2014), Fujikawa H (2013)	20
EMILIN1	1	CEP170	4	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	FBXO46	1	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	UBXN1	0	affinity chromatography technology	Huttlin EL (2017)	1
TAB3	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology	Ishitani T (2003), Kanayama A (2004), Shinohara H (2016)	3
EMILIN1	1	RRBP1	7	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	PPFIA3	5	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	SPAG5	1	affinity chromatography technology	Huttlin EL (2017)	1
ARRB2	5	MAP3K7	2	affinity chromatography technology	Xiao K (2007)	1
TAX1BP1	3	EMILIN1	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
EMILIN1	1	BEX3	0	two hybrid	Rolland T (2014)	1
EMILIN1	1	RIBC1	0	two hybrid	Rolland T (2014)	1
EMILIN1	1	EIF4G1	9	affinity chromatography technology	Huttlin EL (2017)	1
HOMER1	1	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LAIR2	0	EMILIN1	1	two hybrid	Rolland T (2014)	1
TAB1	1	WDCP	2	two hybrid	Vinayagam A (2011)	1
EMILIN1	1	TAB3	1	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	MTMR9	1	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014), Yu H (2011)	4
DCTN2	0	FBXO28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EMILIN1	1	METTL15	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP170	4	ARRB2	5	bioid	Gupta GD (2015)	1
EMILIN1	1	DNAJC12	0	affinity chromatography technology	Huttlin EL (2017)	1
DYNC1I1	1	RPL23	0	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	TRAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	EMILIN2	5	two hybrid	Doliana R (2001)	1
EMILIN1	1	MAP3K7	2	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	SPC24	0	affinity chromatography technology	Huttlin EL (2017)	1
MAP3K7	2	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011), Mendoza H (2008), Criollo A (2011), Hong S (2007), Minoda Y (2009), Liu R (2014), Shinohara H (2016), Zhang J (2017)	13
SPAG5	1	ZC2HC1C	0	two hybrid	Rolland T (2014)	1
EMILIN1	1	TNIP2	1	affinity chromatography technology	Huttlin EL (2017)	1
NMI	3	EMILIN1	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
MAP3K7	2	TAB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Channavajhala PL (2003), Ninomiya-Tsuji J (1999), Sakurai H (2000), Liu XY (2008), Li S (2011), Li S (2011), Ear T (2010), Singhirunnusorn P (2005), Prickett TD (2008), Kim SY (2012), Jiang Z (2002), Shibuya H (1996), Shibuya H (1996), Minoda Y (2009), Minoda Y (2009), Scholz R (2010), Scholz R (2010), Scholz R (2010), Kim SI (2009), Ge B (2003), Blonska M (2005), Kishimoto K (2000), Kishimoto K (2000), Zhu Y (2013), Liu R (2014), Chen TC (2014), Moon G (2015), Ninomiya-Tsuji J (2003), Min Y (2016), St-Denis N (2016), Zhang J (2017)	33
EMILIN1	1	FBXO28	2	affinity chromatography technology	Huttlin EL (2017)	1
FZR1	1	CDC23	3	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
DCTN2	0	DYNC1I1	1	affinity chromatography technology	Splinter D (2012)	1
TAB1	1	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Li S (2011), Li S (2011), Mendoza H (2008), St-Denis N (2016)	6
EMILIN1	1	TRMT61A	0	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	LRIF1	3	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	DCTN2	0	pull down, imaging technique	Ban KH (2007), Ban KH (2007)	2
EMILIN1	1	CDC27	2	affinity chromatography technology, biochemical, imaging technique	Ban KH (2007), Ban KH (2007), Ban KH (2007)	3
ARRB2	5	TAB2	5	imaging technique	Chen TC (2014)	1
EMILIN1	1	HOMER1	1	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	DDHD2	4	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	EMILIN1	1	two hybrid, pull down, two hybrid	Mongiat M (2000), Mongiat M (2000), Rolland T (2014)	3
EMILIN1	1	ARRB2	5	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	ZC2HC1C	0	two hybrid	Rolland T (2014)	1
EMILIN1	1	MTPAP	2	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	RPL23	0	affinity chromatography technology	Huttlin EL (2017)	1
EMILIN1	1	FZR1	1	affinity chromatography technology	Ban KH (2007)	1
NMI	3	MTMR9	1	two hybrid	Rolland T (2014)	1